Clinical and Experimental Pediatrics

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Original Article

Effects of puromycin aminonucleoside on the cytoskeletal changes of glomerular epithelial cells

Jun Ho Lee, Tae Sun Ha

Clin Exp Pediatr. 2008;51(1):54-61. Published online January 15, 2008

of microvilli, but also separated the intercellular gaps and linear ZO-1. PAN induced oxidative stresses in time and dose dependent manners and increases of intercellular permeability in anti-oxidants inhibitable manners. High concentration of PAN induced not only actin polymerization and disorganization, but also the conglomerulation and internal dislocation of α-actinin protein. The intensities of fluorescences of ZO-1 protein were diminished...

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