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Original Article

Neuroprotective effects of L-carnitine against oxygen-glucose deprivation in rat primary cortical neurons

Yu Jin Kim, Soo Yoon Kim, Dong Kyung Sung, Yun Sil Chang, Won Soon Park

Clin Exp Pediatr. 2012;55(7):238-248. Published online July 17, 2012

Crossref 12

Purpose

Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and modulates excess acyl coenzyme A levels. In this study, we investigated whether treatment of primary cultures of rat cortical neurons with L-carnitine was able to prevent neurotoxicity resulting from oxygen-glucose deprivation...

DOI: https://doi.org/10.3345/kjp.2012.55.7.238

Taurine exerts neuroprotective effects via anti-apoptosis in hypoxic-ischemic brain injury in neonatal rats

Ji Eun Jeong, Tae Yeol Kim, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim

Clin Exp Pediatr. 2009;52(12):1337-1347. Published online December 15, 2009

Purpose : Taurine (2-aminoethanesulfonic acid) is a simple sulfur-containing amino acid. It is abundantly present in tissues such as brain, retina, heart, and skeletal muscles. Current studies have demonstrated the neuroprotective effects of taurine, but limited data are available for such effects during neonatal period. The aim of this study was to determine whether taurine could reduce hypoxic-ischemic (HI) cerebral...

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