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Original Article

Kinetics of GABAA Receptors in An Animal Model of Irradiation-induced Neuronal Migration Disorders

Chan Jong Kim, Young Jong Woo, Min Cheol Lee

Clin Exp Pediatr. 2000;43(7):933-941. Published online July 15, 2000

Purpose : A majority of patients with neuronal migration disorders(NMDs) in cortical structures suffer from medically intractable epilepsy. The role of NMDs on seizure susceptibility or epileptogenecity has not been well documented. In the present study, we established an experimental model of NMDs in Sprague-Dawley rats by exposing fetal rats to external irradiation in order to demonstrate epileptogenic effect of NMDs lesions. Methods : Pregnant...

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