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Original Article

Phenobarbital Dosage and Blood Level for Control of Neonatal Seizure

Hye Soon Kim, Keun Lee, Young Sook Ko

Clin Exp Pediatr. 1993;36(12):1641-1646. Published online December 15, 1993

Twenty-five neonates was observe for the relationship between phenobrbital loading dose, plasma concentrations and control of seizures. Nineteen neonates (76%) had seizures controlled by phenobarbital alone, Effective plasma concentration were 10.0~31.3㎍/ml. Although 14 neonates had seizures controlled by phenobarbital concentration below 20㎍/ml, neonate required level above 30㎍/ml. We foound that continued benefit was obtained until phenobarbital plasma concentrations reached 40㎍/ml...

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