Clinical and Experimental Pediatrics

Original Article

Neonatology (Perinatology)

Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea

Ji Yoo Kim, Hyeon Jin Kim, Heeyoon Choi, Minji Kim, Jinseok Lee, Yong Sung Choi, Dong Keon Yon

Clin Exp Pediatr. 2026;69(7):555-562. Published online May 21, 2026

Question: Is metabolic acidosis at birth in very low birth weight infants (VLBWIs) associated with long-term clinical outcomes?
Finding: Metabolic acidosis at birth was associated with increased mortality, adverse respiratory outcomes, neurological morbidities, and infection-related and gastrointestinal outcomes.
Meaning: VLBWIs with metabolic acidosis are at high risk of systemic complications. This finding emphasizes the need for close monitoring and comprehensive care.

DOI: https://doi.org/10.3345/cep.2025.02817

Case Report

A Case of Distal Renal Tubular Acidosis

Bin Cho, Dong Sung Kim, Byung Churl Lee

Clin Exp Pediatr. 1994;37(1):115-112. Published online January 15, 1994

Distal renal tubular acidosis (RTA) is a biochemical syndrome as a dificiency of hydrogen ion secretion by the distal tubule and collecting duct. Owing to the nature of the defect, hyperchloremic non-anion gap metabolic acidosis and high urine pH despite severe systemic acidosis is characterized. Typical manifestations of distal RTA are growth retardation, rickets, polyuria and nephrocalcinosis. We experienced a case of...

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Original Article

A Case of Methylmalonic Acidemia.

Jong Hoon Park, Si Houn Hahn, Kee Hwan Yoo, Kwang Chul Lee, Chang Sung Sohn, Pyung Hwa Choe

Clin Exp Pediatr. 1989;32(7):984-989. Published online July 31, 1989

Methylmalonic acidemia is an inborn error of metabolism, which is characterized by excretion of large amount of methylmalonate, and is transmitted as an autosomal recessive traits. The clinical symptoms begin in early life and are recurrent vomiting, lethargy, dehydration, failure to thrive. Laboratory findings show ketosis, metabolic acidosis, methymalonic aciduria with normal serum cobalamin level, hyperammonemia, pancytopenia. Two treatment regi- mens exist and should...

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