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Review Article

Infection

Four months of rifampicin monotherapy for latent tuberculosis infection in children

Chi Eun Oh, Dick Menzies

Clin Exp Pediatr. 2022;65(5):214-221. Published online October 29, 2021

Web of Science 6 Crossref 6

· Recently, the importance of a short-term treatment regimen including rifamycin has been highlighted in the treatment of latent tuberculosis infection (LTBI).
· Four prospective or retrospective studies in children consistently reported that a 4-month daily rifampicin regimen (4R) had a higher completion rate than and comparable safety to a nine-month daily isoniazid regimen.
· We suggest rifampicin 20–30 mg/kg/day for children aged 0–2 years and 15–20 mg/kg/day for children aged 2–10 years in 4R to treat LTBI.

DOI: https://doi.org/10.3345/cep.2021.01186

Original Article

Infection

Usefulness of interferon-γ release assay for the diagnosis of latent tuberculosis infection in young children

Ki Wook Yun, Young Kwang Kim, Hae Ryun Kim, Mi Kyung Lee, In Seok Lim

Clin Exp Pediatr. 2016;59(6):256-261. Published online June 30, 2016

Crossref 11

Purpose

Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI.

Methods

We performed a tuberculin skin...

DOI: https://doi.org/10.3345/kjp.2016.59.6.256

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