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Original Article

Serum Nitric Oxide and Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease

Ji Hye Park, Jee Seon Shin, Young Mi Hong

Clin Exp Pediatr. 2005;48(7):772-778. Published online July 15, 2005

Purpose : Kawasaki disease(KD) is a systemic panvasculitis that causes coronary artery lesions. KD is accompanied by immunoregulatory abnormalities. Nitric oxide(NO) can induce relaxation of blood vessels by activating guanylate cyclase in smooth muscle cells and high levels of NO may result in coronary artery lesions. We investigated tumor necrosis factor(TNF)-α and NO production before and after intravenous immunoglobulin(IVIG) therapy...

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