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Case Report

Aplastic Crisis Secondary to Parvovirus B19 Infection

Yang Joon Park, Dae Kyun Koh, Jin Hee Oh

Clin Exp Pediatr. 2003;46(11):1139-1142. Published online November 15, 2003

Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with...

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