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Original Article

1-β-D-Arabinofuranosyl-cytosine Induces Chromosomal Breaks in vitro

In-sang Jeon

Clin Exp Pediatr. 2003;46(12):1186-1193. Published online December 15, 2003

Purpose : Fragile sites are points on chromosomes which tend to break non-randomly when exposed to specific chemical agents or conditions of tissue culture. The chromosomal break induced by the antineoplastic drug, 1-β-D-arabinofuranosyl-cytosine(Ara-c), was investigated to study the laboratory conditions in which the incidence of chromosomal break could be enhanced. Besides, the fragile sites induced by Ara-C were investigated...

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