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Original Article

Effect of Hypoxia-ischemia on c-fos Expression in the Neonatal Rat Brain

Wang Bock Lee, Sun Hak Kwon, Heng Mi Kim

Clin Exp Pediatr. 2000;43(3):386-394. Published online March 15, 2000

Purpose : Brain damage resulting from a combination of hypoxia and ischemia in the newborn infant remains a major cause of perinatal death, cerebral palsy, mental retardation and epilepsy. Metabolic stress, including ischemia, hypoxia and seizures, induces the expression of a variety of stress proteins including nuclear proto-oncogene c-fos. The induction of c-fos can be considered a biomarker of events...

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