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Original Article

Neuroprotective effects of L-carnitine against oxygen-glucose deprivation in rat primary cortical neurons

Yu Jin Kim, Soo Yoon Kim, Dong Kyung Sung, Yun Sil Chang, Won Soon Park

Clin Exp Pediatr. 2012;55(7):238-248. Published online July 17, 2012

Crossref 12

Purpose

Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and modulates excess acyl coenzyme A levels. In this study, we investigated whether treatment of primary cultures of rat cortical neurons with L-carnitine was able to prevent neurotoxicity resulting from oxygen-glucose deprivation...

DOI: https://doi.org/10.3345/kjp.2012.55.7.238

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