Clinical and Experimental Pediatrics

Original Article

Prenatal stress via chronic immobilization amplifies N-methyl-D-aspartate-induced spasm-like seizure susceptibility and neuroinflammation in neonatal rats

Hyeok Hee Kwon, Seungyeon Bin, Seung Gyu Choi, Hyo Jung Shin, Joon Won Kang

Background: Prolonged stress during pregnancy is associated with various neurodevelopmental abnormalities and an increased risk of neurological disorders. Although prenatal stress is implicated in altered brain development, its contribution to infant seizures remains unclear. Specifically, the effects of prolonged prenatal stress on seizure susceptibility and the mechanisms underlying this association remain unclear.
Purpose: Infantile spasms, also known as West syndrome, are age-specific epileptic seizures. Most affected patients exhibit signs of...

DOI: https://doi.org/10.3345/cep.2026.01403 [Accepted]

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Neurology

Clinical manifestations of headache in children younger than 7 years

Bu Seon Kang, Jinsun Lee, Jin Hyuk Choi, Hyeok Hee Kwon, Joon Won Kang

Clin Exp Pediatr. 2018;61(11):355-361. Published online September 16, 2018

Crossref 8

Purpose: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children <7 years of age. Methods: We reviewed 3 years of clinical files on children <7 years of age with a chief complaint of headache. Results: This study included 146 children (66 males, 80 females; mean...

DOI: https://doi.org/10.3345/kjp.2018.06331

Outcome of ultrasonographic imaging in infants with sacral dimple

Jin Hyuk Choi, Taekwan Lee, Hyeok Hee Kwon, Sun Kyoung You, Joon Won Kang

Clin Exp Pediatr. 2018;61(6):194-199. Published online June 25, 2018

Crossref 11

Purpose

Sacral dimples are a common cutaneous anomaly in infants. Spine ultrasonography (USG) is an effective and safe screening tool for patients with a sacral dimple. The aim of this study was to determine the clinical manifestations in patients with an isolated sacral dimple and to review the management of spinal cord abnormalities identified with USG.

Methods

We reviewed clinical records and collected...

DOI: https://doi.org/10.3345/kjp.2018.61.6.194

Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats

Hyeok Hee Kwon, Taekwan Lee, Jinpyo Hong, Dong Woon Kim, Joon Won Kang

Clin Exp Pediatr. 2018;61(5):150-155. Published online May 28, 2018

Crossref 5

Purpose

Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.

Methods

We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their...

DOI: https://doi.org/10.3345/kjp.2018.61.5.150

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