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Original Article

Comparison of Efficacy of Various Oral - Hypoglycemic Agents on Diabetes Insipidus

Heung Kyu Kim, Yang Hyun Park, En Yul Yum, Ki Bok Kim

Clin Exp Pediatr. 1972;15(5):412-415. Published online May 31, 1972

The efficacy of three oral hypoglycemic agents, all sulfonylurea derivatives (Chlorpropamide, Tolbutamide and Tolazamide) were compared in the case of a 6-year-old girl suffering from diabetes insipidus. Chlorpromide was demonstrated to be the most effective, Tolbutamide slightly effective, and Tolazamide lacked antidiuretic action. Comparison of molecular structures of these agents revealed that replacement of Cl in para-position with methyl radical did not greatly...

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