| Comparison of Efficacy of Various Oral - Hypoglycemic Agents on Diabetes Insipidus
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Heung Kyu Kim, Yang Hyun Park, En Yul Yum, Ki Bok Kim |
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Department of Pediatrics, Kwangju Christian Hospital |
| 뇨붕증세 있어서 수종의 경구 저혈당제의 항 이뇨효과의 비교 |
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김흥규, 박양현, 염은열, 김기복 |
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광주기독병원 소아과 |
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| Abstract |
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The efficacy of three oral hypoglycemic agents, all sulfonylurea derivatives
(Chlorpropamide, Tolbutamide and Tolazamide) were compared in the case of a 6-year-old girl suffering from diabetes insipidus. Chlorpromide was demonstrated to be the most effective, Tolbutamide slightly effective, and
Tolazamide lacked antidiuretic action.
Comparison of molecular structures of these agents revealed that replacement of Cl in para-position
with methyl radical did not greatly influence the antidiabetic efficacy, whereas replacing the propylradical
with other complex radicals markedly affects the efficacy.
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