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The Mitral Regurgitation in Patent Ductus Arteriosus (PDA)
Hyang Suk Yoon, Soon Ho Choi
Clin Exp Pediatr. 1994;37(3):317-321.   Published online March 15, 1994
Mitral regurgitation (MR) was analyzed by Doppler echocardiography, preoperatively and postoperatively, in 59 patients with patent ductus arteriosus (PDA). The ratio of left atrial dimension and aortic root dimension (LAD/LOD) and the maximal velocity of the mitral valve (MV max) were compared in pre, postop group. The degree of the regurgitation was given to the MR group. In preop MR...
The Effect of Long-Acting Gonadotropin-Releasing Hormone (GnRH) Analog on the Growth Velocity and Final Adult Height in the Children with True Precocious Puberty
Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1994;37(3):309-316.   Published online March 15, 1994
The final adult height in the children with true precocious puberty are destined to be short due to excessive bone maturation, compared to the growth velocity, regardless of its etiologies. To improve this final shortness, long-acting GnRH analog have been tried to the children with true precocious puberty. We evaluated the parameters of the growth, including the growth velocity, height...
The Correlation between the Bone Age and Predicted Adult height, Final Adult Height in the Children with Congenital Adrenal Hyperplasia, Especially 21-Hydroxylase Deficiency
Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1994;37(3):300-308.   Published online March 15, 1994
We studied the correlation between the bone age and the predicted adult height, final adult height in the 69 children (30 salt losing form and 39 non-salt losing form) diagnosed as 21-hydroxylase deficiency, retrospectively. The results were as belows; 1) The bone age was similar to the chronological age in the children with salt-losing form (5.3±3.5 years, respectively), but the bone age...
Acute Tubular Necrosis Associated with typhoid Fever
Pill-Jin Shin, Ho-Sung Lee, Byoung-Soo Cho, Chang-Il Ahn, Mun-Ho Yang
Clin Exp Pediatr. 1994;37(2):250-256.   Published online February 15, 1994
Acute tubular necrosis has been rarely reported as a complication of typhoid fever in the literature. We experienced four cases of acute tubular necrosis associated with typhoid fever in children. Patients showed significant titer of widal reaction associated with acute renal failure and one of them rised in 2 months after onset of clinical symptoms. Renal biopsy findings were compatible with acute...
Normal Predicted values of Pulmonary function Test in Korean Primary School-Aged Children
Dae Hyun Lim, Jeong Hee Kim, Jun Hee Park, Jong Woon Choi, Soon Ki Kim, Byong Kwan Son
Clin Exp Pediatr. 1994;37(2):240-249.   Published online February 15, 1994
Pulmonary function test is one of the most important tools in the management of patients with respiratory tract diseases and allergic diseases. As with the difficulties in performing the test, it has been seldom used in pediatric field. But with the advent of simple, computerized tools, pediatric pulmonologist and allergist try to manage the patients using PFE. Still the normal...
Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique
Jin Sook Kim, Young Ran Yoon, Mi Kyung Kim, Hye Kyung Han, Mi Ryung Um, Kyung Hoon Choi, Mi Na Lee, In Keol Moon, In Kweon Han
Clin Exp Pediatr. 1994;37(2):231-239.   Published online February 15, 1994
Total 8,341 pregnant women who visited Obstetric clinic Cheil General Hospital from January 1991 to July 1992 were screened for HBsAg. Sixty five women with positive HbsAg who delivered healthy babies during that period and their infants are included in the study. HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were tested by radioimmunoassay and hepatitis B virus DNA were studied by polymerase...
The Significance of Bacteriologic Examination in the Childhood Tuberculosis
Kyung Bae Kwon, Jin Young Park, Bo Young Yoon, Mee Ran Kim, Hoan Jong Lee, Eui Jong Kim, Sang Jae Kim
Clin Exp Pediatr. 1994;37(2):221-230.   Published online February 15, 1994
We reviewed retrospectively the medical records of 229 cases of tuberculosis, who had been diagnosed clinically and admitted to the department of pediatrics, Seoul National University Children's Hospital, during the period of 6 years from October, 1985, to October, 1991. Patients with tuberculosis occupied 1.2%. of the hospitalized patients. Forty-three percent of the patients were under 3 years of age. Principal...
Chronic Diarrhea In Infancy
Hee Soo Kim, Ki Sup Chung
Clin Exp Pediatr. 1994;37(2):212-220.   Published online February 15, 1994
Diarrhea is an extremely common cause of morbidity in infancy. Occasionally it becomes protracted, leading to a vicious cycle of malabsorption, malnutrition and failure to thrive. Thirty nine infants of chronic diarrhea who had been admitted to the Department of pediatrics, Yonsei University College of Medicine for 3 years between September, 1989 and December 1992, were clinically studied and analogized,...
Role of Adenovirus in Diarrheal Children
Gyung Ok Yu, Young Bae Moon, Dong Rak Choi, Duk Ha Kim, Hae Ran Lee, Chong Young Park, Hee Jung Kang, Kyu Man Lee
Clin Exp Pediatr. 1994;37(2):205-211.   Published online February 15, 1994
In order to investigate the role of adenovirus in diarrheal children, we evaluated 907 children with diarrhea and 193 children without diarrhea for a 22-month. Stools were tested for group A rotavirus antigen and for adenovirus types 40/41 (Ad 40/41) by using ELISA, cell technique and indirect immunofluorescent method. Adenovirus was detected in 10.1% of the diarrheal children and 3.1%...
Clinical Studies of Salmonelosis in Childhood
Hong Shin Jeon, Young Jin Hong, Myung Ik Lee, Keun Chan Sohn
Clin Exp Pediatr. 1994;37(2):199-204.   Published online February 15, 1994
During The last 11 years from Jan. 1980 to Dec. 1990, 72 cases of salmonellosis has been admitted to the Department of Pediatrics of National Medical Center and evaluated clinical difference between typhoid fever and salmonella gastroenteritis. The result were as follows: 1) The annual incidence of salmonella gastroenteritis in salmonellosis was increased in the latter half of the eighties. 2) Both...
The Sexual Maturity Rating of Adolescent Boys and Girls in Korea
Chang-Ho Hong, Hae-Ok Rho, Sang-Hi Song
Clin Exp Pediatr. 1994;37(2):193-198.   Published online February 15, 1994
There are ethnic differences in the timing of sexual maturaion. However, averages of sexual maturity rating (SMR) for Korean adolescents were not available until recently. The purpose of this study was to determine averages for the SMR of adolescent girls and boys in Korea. The study population included 3,249 boys and 3,337 girls. The sample comprised 2,406 from the Seoul area,...
Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function
Jin Young Park, Ktung Bae Kwon, Mee Ran Kim, Hoan Jong Lee, Jin Q Kim, Wan Gyoon Shim, Kyoung Ho Park, Hae Lim Chung
Clin Exp Pediatr. 1994;37(2):185-192.   Published online February 15, 1994
We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum by method of Sawchuck. There was wide individual variation in peak serum concentrations of gentamicin and amikacin. Administration of the usually recommended doses yielded subtherapeutic concentration in 47% and 82%,...
Exchange Transfusion Using Percutaneous Femoral Vein Catheterization in Neonates: Comparison with Umbilical Vein Catheterization
Song-Ja Kim, Hyang-Ok Woo, Seung-Hwan Kim, Mi-Ryeong Kim, Sun-Kyeong Sin, Hee-Shang Youn
Clin Exp Pediatr. 1994;37(2):180-184.   Published online February 15, 1994
Traditionally umbilical vein has been used for exchange transfusion in neonates. This method is relatively safe and effective but with a few complications. So via percutaneous femoral vein catheters we tried exchange transfusion in 30 patients with neonatal hyperbilirubinemia admitted to GNUH from September 1990 to August 1992. Femoral vein catheterization succeeded in 2~3 trials. In all cases high bilirubin level...
Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
Clin Exp Pediatr. 1994;37(2):174-179.   Published online February 15, 1994
The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical...
The Clinical Observation in Kawasaki Disease
Min-Young Park, Gye-Sik Shim, Sung-Ho Cha, Chang-Il Ahn
Clin Exp Pediatr. 1994;37(2):167-174.   Published online February 15, 1994
One-hundred ninty five cases with Kawasaki disease who diagnosed and treated at the Department of Pediatrics, Kyung Hee University Hospital from January 1985 to June 1993, were investigated for their clinical manifestations and laboratory findings, and cardiac complications. The results are as follows: 1) Most patients (92.8%) were under 5 years of the age. 2) Boys were more prevalent than girls, as a...
Improvement of Thoracic Pressure-Volume, Complincace and Histological Characteristics in Premature Newborn Rabbit after Treatment of Bovine Purified Natural Surfactant-Phospholipid
Chong-Woo Bae, Chang Il Ahn, Haruo Maeta, Tetsuro Fujiwara
Clin Exp Pediatr. 1994;37(2):157-166.   Published online February 15, 1994
We had previously reported the purification of bovine lung natural surfactant-phospholoipd (PNS-L) and the assessment of it's surface physical properties in vitro. To observe the clinical effectiveness of PNS-L in vivo, the degree of improvement of thoracic pressure-volume, compliance and histological changes following PNS-L instillation in premature rabbits with respiratory distress syndrome (RDS) were investigated. Rabbits, delivered prematurely by cesarean section...
The Growth Hormone Response to Growth Hormone-Releasing Hexapeptide (GHRP-6) in the Sprague Dawley Rat with Hypothyroidism
Sei Won Yang
Clin Exp Pediatr. 1994;37(1):89-98.   Published online January 15, 1994
We studied the effects of growth hormone to subthreshold, threshold, or suprathershold dose of growth hormone-releasing hexapeptide (GHRP-6) in conscious and unconscious (anesthesized with ketamine and phenobarbital) female Sprague Dawley rats with hypothyroidism, induced with methimazole and compared these results with those in conscious and unconscious rats with euthyroidism. The results were as below; 1) In conscious rats, the peak GH response...
Risk Factors and Outcome of Bronchopulmonary Dysplasia
Beyong Il Kim, Yun Sil Chang, Dong Woo Son, Hae Kyung Han, Jung-Hwan Choi, Chong Ku Yun, In One Kim, Kyung Mo Yeon, Je G. Chi
Clin Exp Pediatr. 1994;37(1):78-88.   Published online January 15, 1994
The 45 neonates with bronchopulmonary dysplasia among 355 neonates who were managed with mechanical ventilation and oxygen therapy in NICU of Seoul National University Chhildren's Hospital from January 1, 1968 to December 31, 1991, were analyzed for risk factors and outcome. The results were as follows: 1) The incidence of bronchopulmonary dysplasia was 12.7% 2) Respiratory Distress Syndrome was most common underlying problem. 3)...
Choleithiasis in Childhood
Soon Young Kim, Jeong Kee Seo
Clin Exp Pediatr. 1994;37(1):70-77.   Published online January 15, 1994
Nineteen children found to have gallstones at Seoul National University of Children's Hospital form Jun. 1982 to Jun. 1992 wee reviewed. The results were as follows: 1) The mean age was 10 years, with 9 boys and 10 girls. Most of the cases (63%) were over 10 years of age. 2) Clinical manifestations were abdominal pain (14 cases), naused and/or vomiting (5 cases), fever...
Cardiac Rhabdomyoma in Children-A Report of 26 Cases
Ho Sung Kim, Youn Woo Kim, Wun Jung Bae, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1994;37(1):61-69.   Published online January 15, 1994
We reviewed 26 cases of Cardiac rhabdomyoma in children which were diagnosed between 1986 and 1991 in Seoul National University Children's Hospital. Twenty-two cases were associated with tuberous sclerosis. Total tumor count was 58 and mean tumor count per patient was 2.23. Their Cardiac rhabdomyoma were diagnosed from fetal period through 12 years after birth. Median age was 9.5 months....
A Clinical Observation of Neonatal Hyperbilirubinemia Due to ABO imcompatibility
Kang Woo Lee, Young Guk Kim, Dong Gun Park, Kee Hwan Yoo, Kwang Chul Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(1):54-60.   Published online January 15, 1994
A clinical and statistical study was performed on 213 neonates of hyperbilirubinemia who were admitted to department of pediatrics of Korea University Hospital from Jan. 1989 to Jun. 1991. And we studied the difference between ABO compatible group and incompatible group, such as, day of appe5rance of hyperbilirubinemia, tendency of bilirubin concentration change, reticulocyte, hemoglobin and duration of hyperbilirubinemia. The following...
Analysis on the Cause of Eosinophilia in Premature Infants
Woo Sik Kang, Suck Kyu Hur, Mee Kyung Namgoong, Hwang Min Kim, Baek Keun Lim
Clin Exp Pediatr. 1994;37(1):47-53.   Published online January 15, 1994
Eosinophilia is a common finding in premature babies during the neonatal period. Serial eosinophil counts were determined in 94 hospitalized, appropriately grown premature infants whose gestational ages ranged from 28 to 36 weeks. The incidence, sseverity and etiologic factors of eosinophila were retrospectively studied in premature infants, who were divided into three groups according to their gestational age. The results were...
Urinary Red Cell Volume in the Diagnosis of Glomerular and Non-Glomerular Heaturia in children
Jong Sul Kwon, Dong Seok Kim, Myung Sung Kim, Joon Sik Kim, Chin Moo Kang, Dong Seok Jeon
Clin Exp Pediatr. 1994;37(1):40-46.   Published online January 15, 1994
Hematuria is a important clinical sign that is a consequence of significatn renal, urologic or sytemic disease. Recently the morphology of the red cell in hematuria has been used to indicate a renal or non-renal source and also the measurement of red cell volume by red cell analyzer has been used to distinguish glomerular from non-glomerular hematuria. In this study, the...
Diagnostic Significance of Red Cell Indices in Non-anemic Iron Deficiency and Iron Deficiency Anemia: Reevaluation with ROC Curve
Hwang Min Kim, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1994;37(1):33-39.   Published online January 15, 1994
To validate the diagnostic significance of red cell indices in non-anemic iron deficiency and iron deficiency anemia, complete blood count, serum iron, total iron binding capacity, and serum ferritin were measured in 208 middle school girls between 13 and 15 years age. We used Reciever Operating Characteristic (ROC) curve to compare the diagnostic significances of various red cell indices (MCV,...
A Clinical Study of Serologically Diagnosed Yersinia Pseudotuberculosis Infection in Children
Mi Won Kim, Youn Jeong Jeong, Yong Kyu Lee, Jeong Wan Seo, Jin Keun Chang, Hoan Jong Lee
Clin Exp Pediatr. 1994;37(1):26-32.   Published online January 15, 1994
A retrospective analysis of clinical findings in 23 patients with Y. pseudotuberculosis infection who visited Department of Pediatrics of Han Il Hospital from May, 1990 to June, 1992 was performed. 1)The most prevalent age group was 7 to 12 years (16 case:69.6) and male-to-female ratio was 1.1:1. 2) Monthly distribution showed a high frequency in April, May and June(22 cases:95.8%) 3)The common symptoms...
Prediction of Neurologic Outcome of Perinatal Asphyxia by Use of CK-BB Isoenzyme Measurements
Eun Sik Kang, Jung Hea Park, Hea Jin Choeh, Chong Sung Chung, Kyuchul Choeh
Clin Exp Pediatr. 1994;37(1):19-25.   Published online January 15, 1994
Creatine kinase (CK) isoenzyme are considered as a specific tissue injury marker. Brain tyupe isoenzyme of CK (CK-BB) was measured in 44 healthy and 33 asphyxiated preterm and fullterm infants. Samples were drawn from peripheral blood at six to ten hours after birth. There were no difference of CK-BB and CK-BB% between preterm and fullterm infants. CK-BB and CK-BB% were well...
The Incidence of Allergic Disease among the Pediatric Outpatient
Jeong Hee Kim, Jun Hee Park, Dae Hyun Lim, Soon Ki Kim, Byong Kwan Son
Clin Exp Pediatr. 1994;37(1):9-18.   Published online January 15, 1994
The incidence of allergic disease in pediatric outpatient department of a hospital, where primary care is undertaking, was studied from Arp. 1, 1989 to Mar. 32, 1990. The results were as follows, 1) The incidence of respiratory tract disease was the highest with the value of 57.2% of the total patients, followsed by gastrointestinal tract disease (13.9%), infectious disease (6.7%), visit...
Clinical Study of Febrile convulsion and Factors Related to Recurrence
Jong Gyun Kim, Keon Su Rhee, Young Hun Chung
Clin Exp Pediatr. 1994;37(1):1-8.   Published online January 15, 1994
We have reserched the relationship of their clinical pictures and factors related to the risk of recurrence of 75 patients with simple or complex febrile convulsions, who were admitted to the Department of Pediatrics, Chungnam National University Hospital from January 1987 to July 1991. The 75 patient were followed up and consisted of the 55 patients with initial or non-recurrent...
Cyclosporin A Treatment of Minimal Change Nephrotic Syndrome and Focal Segmental Glomerulosclerosis
Ik Jun Lee
Clin Exp Pediatr. 1993;36(12):1740-1746.   Published online December 15, 1993
In this study I assesed the efficacy and tolerance of cyclosporin A (CyA) in the treatment of steroid-dependent MCNS (minimal change nephrotic cyndrome) and steroid resistant FSGS (focal segmental glomerulosclerosis). The results showed, that 1) CyA was effective in sustaining a remission in steroid-dependent MCNS without prednisone treatment, and therefore, could be an alternative therapeutic choice. 2) After discontinuation of CyA, relapses reccurred...
Stastical Studies on Pediatric Emergency Room Patients
Kyoung Dug Moon, Won Ah Park, Hae Kyung Lee, Young Hee Yu, Hyun Suk Lee
Clin Exp Pediatr. 1993;36(12):1732-1739.   Published online December 15, 1993
The authors reviewed 3145 pediatric patients who visited the emergecy room in the hospital during 3yrs period from Jan. 1989 to Dec. 1991. 1) Among the patients visiting the emergency room, the patients under 15 years of age were 26.4% (3145) of total emergency patients (11930). 2) Yearly distribution of patients were decreased 17% between 1989 and 1991. 3) Monthly distribution of visits...
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