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Original Article
Clinical Review of Positive Antinuclear Antibody(ANA) Test in Pediatric Patients
Dong-Jin Choi, Kye-Sik Shim, Hyok Choi, Byoung-Soo Cho, Sung-Ho Cha, Jin-Tae Suh
Clin Exp Pediatr. 1994;37(10):1397-1404.   Published online October 15, 1994
The antinuclear antbody (ANA) test have been used to screen the patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. We had retrospectively reviewed the 263 records of pediatric patients with doing ANA tests who admitted at Department of Pediatrics, Kyung Hee University Hospital, from January 1988 to May 1993. The following results were obtained. 1) The positive rate of ANA...
Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System
Kwang-Ju Lee, Young-Hun Chung, Jae-Ho Lee
Clin Exp Pediatr. 1994;37(10):1386-1396.   Published online October 15, 1994
We have studied the function of lymphokines on human tonsillar B cell proliferation and differentiation. B cells were stimulated with Staphylococcus aureus Cowan1(SAC) or anti-μ bead. The followings showed the results of this study. 1) In B cell activation, SAC induced B cell DNA synthesis but anti-μ bead did not. SAC could activate and proliferate B cells. Minimal number of B cells...
Neurosonographic Abnormality; Periventricular echodensities and Intraventricular Hemorrhage: Usefulness in Predicting Neurodevelopmental Outcome in Very-Low-Birth-Weight, Preterm Infants
Dae Young Jang, Keun Wook Lee, Young Taek Jang, Oh Kyung Lee, Jin Ok Choi, Yeon Hi Kim
Clin Exp Pediatr. 1994;37(10):1376-1385.   Published online October 15, 1994
Serial neurosonographic examinations are routinely performed at frequent intervals during nursery couse of all preterm infants of very low-birth-weight who are admitted to the intensive care nursery of Presbyterian Medical Center from November 1,1900 to July 30, 1992. After discharge, the following survivors who had received periodic, serial scanning by means of cranial ultrasonography were longitudinally observed in an interdisciplinary neurodevelopmental...
Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(10):1364-1375.   Published online October 15, 1994
To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain...
Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(10):1357-1363.   Published online October 15, 1994
In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University...
The Study on the Clinical Significance of the Finger Extension Reflex in Early Infancy
Seong Yeob Moon, In Joon Seol
Clin Exp Pediatr. 1994;37(10):1350-1356.   Published online October 15, 1994
The finger extension reflex was performed to the 419 normal infants without CNS abnormalities that visited to the well baby clinic and out-patient department, and so to the patients with CNS abnormalities on the brain sonography and brain CT under the age of 2 months from May 1992 to September 1993 in the department of pediatrics, Hanyang university hospital. The results...
Right Ventricular Area, Dimension, and Volume Measured by Two-dimensional Echocardiography in Normal Children
I-Seok Kang, Jung-Yun Choi
Clin Exp Pediatr. 1994;37(10):1340-1349.   Published online October 15, 1994
The usefulness of two-dimensional echocardiography to measure the right ventricular volume was assessed in 58 normal children(mean age 5 years and 3 months). From the apical 4-chamber view(A4CV), the subcostal RV sagittal view(SCRVSV), the subcostal right anterior oblique view(SCRAOV), and the subcostal RV coronal view(SCRVCV), the dimensions and areas of the right ventricle were measured. The right ventricular volumes and...
Airway Resistance after Exercise Loading Test in Asthmatic Children
Ji Eun Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1994;37(10):1333-1339.   Published online October 15, 1994
Exercise induced asthma(EIA) is defined as acute, reversible, usually self-immiting airway obstruction which develop after strenous exercise in patients with asthma. EIA is a bigger problem in children than adults due to more active and smaller airways which obstruct more easily when bronchospasm develops. The exercise elicited amny change in pulmonary function of asthmatic children. These change could be measured...
Study on Child Mortality among Korean Children
Beom Soo Park, Moo Song Lee, Seung Pil Jeong, Yoon Ok Ahn
Clin Exp Pediatr. 1994;37(9):1264-1272.   Published online September 15, 1994
To estimate the child and infant mortality rates among Korean children, a mortality survey was carried out in the province of Kyongsangnam¡¤buk-do. The study popolation are the beneficiaries of Korea Medical Insurance Coorporation(KMIC), Kyongsangnam¡¤buk-do area, among which the 3,867 and 1767 deaths occurred from Januray, 1989 to December, 1990 in Kyongsangnam-do area and from January, 1991 to December, 1991 in...
The Role of Urinary Sodium at Transient Renal Acidification Defect during Acute Infantile Actue Gastroenteritis
Clin Exp Pediatr. 1994;37(9):1257-1263.   Published online September 15, 1994
The pupose of this study is to verify the role of urinary sodium in transient renal acidification defect which frequently combine acute infantile gastroenteritis. We studied on twenty-five infants, 2 month to 36 month of age, during the 4 month period, from August, 1991 to December, 1991. The patients had acidosis for a mean of 3 days and sixty urine...
A Clinical Study of Benign Epilepsy of Childhood with Centrotemporal Spikes
Byung Il Lee, Sang Ju Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee
Clin Exp Pediatr. 1994;37(9):1251-1256.   Published online September 15, 1994
Benign epilepsy of childhood with centrotemporal spikes(BECCT) is an electroclinical syndrome characterized by noctural seizure that remit spontaneouly before adulthood, and belong to idiopathic age and location related epilepsies. We reviewed the medical records to analyse the seizure pattern, and also inspect the EEG recording to identify topography of the epileptiform discharge of 24 patient who met the following criteria: 1)presence...
The Roles of IgG and Albumin as a Predictor of Frequent Relapse
Jae-Ho Lee, Jong-Gyun Kim
Clin Exp Pediatr. 1994;37(9):1245-1250.   Published online September 15, 1994
The etiology of nephrotic syndrome is unknown. The characterization were proteinuria, hypoalbuminemia, generalized edema and hyperlipidemia. To assess the recurrence factors in the nephrotic syncrome, we measured serum immunoglobulin(IgG, IgA, IgM), albumin, complement, cholesterol and the 24-hour total urine protein at the initial relapse of nephrotic syndrome. Each data of frequent and infrequent relapsed nephrotic syndrome were compared. In total...
A Clinical Study of Childhood Systemic Lupus Erythematosus
Young-Jun Kim, Young Don Kim, Jae Hong Park, Su Young Kim, Hee-Ju Park
Clin Exp Pediatr. 1994;37(9):1235-1244.   Published online September 15, 1994
To Evaluate the clinical characteristics of childhood-onset systemic lupus erythemoatosus (SLE) and analyse the factors related to outcome of renal function in lupus nephritis, we reviewed medical records of 18 cases of SLE diagnosed at the Department of Pediatrics, Pusan Nationsl University Hospital from January 1981 to December 1990. The results were as was 1:2.6 1)Male...
Detection of Enterovirus in Patients with Aseptic Meningitis by Reverse Transcription and Polymerase Chain Reaction
Souck Joong Yoon, Sung Jin Hong, Young Hyuk Lee, Min Hee Kim, Kyo Sun Kim, Kyu Hyun Park, Jae Myun Lee, Won Young Lee
Clin Exp Pediatr. 1994;37(9):1226-1234.   Published online September 15, 1994
The aim of this study was to determine the applicability of reverse transcription and polymerase chain reaction(RT/PCR) for routine diagnostic use and for the detection of enteroviral mentigitis, Primers were selected in the highly conserved part of the 5'-non-coding region of the enteroviral genome. Enteroviral RNA was detected by the RT/PCR in routinely collected cerebrospinal fluids(CSF) of patients with aseptic...
Pulmonary Venous Flow Pattern by Doppler Echocardiography before and after Closure of Ductus Arteriousus in Newborns
Young Mi Hong
Clin Exp Pediatr. 1994;37(9):1213-1219.   Published online September 15, 1994
Color Doppler echocardiography was performed to evaluate pulmonary venous flow pattern at 1st~2nd day of birth in 84 fullterm newborns (36: patent ductus arteriosus, 48: closed ductus arteriosus). Aortic and pulmonic diameter, velocity and integral were estimated. The purpose of this study ascertained that patent ductus arteriosus changed the pulmonary vein velocity and flow integral. The results were...
The Accuracy of Pulse Oximeter in Pedicting the Arterial Oxygen Saturation
Jeong Hye Lee, Mi Sook Kim, Seong Sook Jeon, Son Sang Suh
Clin Exp Pediatr. 1994;37(9):1205-1212.   Published online September 15, 1994
We studied 21 neonates who required mechanical venilation during study period in NICU OF Il Sin Christian Hospital with diagosis of prematurity, IRDS, pneumothorax and diaphragmatic hernia to evaluate the accuracy of pulse oximeter in predicting the arterial oxygen saturation, hypoxia and hyperoxemia. We also studied wheter the changes of birth weight, hematocrit, blood pressure and body temperature affect the accuracy...
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(9):1196-1204.   Published online September 15, 1994
Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)...
Physical Growth According to Sexual Maturation of Korean Adolescents
Hwan Gyu Park, Chang Ho Hong, Duk Hi Kim
Clin Exp Pediatr. 1994;37(9):1187-1195.   Published online September 15, 1991
Adolescence is the period in which physical, mental and social maturation occurs and it is an important transit stage, changing from childhood to adulthood. This is a period in which important changes occur physically such as rapid growth in height and weight gain but significant differences in growth may occur for the same age. Therfore, the degree of sexual maturation...
Epstein-Barr Viral Hepatitis in Childhood
Soo Kyung Lee, Ki Sup Chung
Clin Exp Pediatr. 1994;37(8):1124-1135.   Published online August 15, 1994
We analysed 58 patients who were admitted to the Department of Pediatrics, yonsei University College of Medicine due to infectious mononucleosis from January 1986 to August 1992. Of 58 patients who had responses to IgM to EBV viral capsid antigen and/or heterophil antibody, 35 patients had hapatitis. Of 35 hepatitis patients, group I consisted of 22 patients who had only...
Chronic Cough in Children
Bin Cho, Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1994;37(8):1116-1123.   Published online August 15, 1994
Chromic cough is a symptom frequently encountered by the pediatrician. Although most coughs are self-limited, chronic cough ofter proves to be a frustrating problem. This study was performed at Kangnam St. Mary's Hospital from January 1,1992 to December 31, 1992, and 83 children with chronic cough persisting for longer than 3 weeks was evaluated. We categorized these patients into 5...
A Study on Blood Lead Levels in Pediatric Inpatients
Young Ho Lee, Hyoung Shim Chang, Bong Keun Choi, Kyu Geun Hwang, Ahn Hong Choi
Clin Exp Pediatr. 1994;37(8):1111-1115.   Published online August 15, 1994
Lead is one of the most widespredad environmental toxins and its poisoning in children was considered a rarity, usually resulting from unique circumstances such as inappropriate use of lead-based body cosmetics or direct administration of lead-containing folk medicines. The increasing concern about children with lower levels of lead exposure has developed, but there are no data regarding the mean blood...
A Clinical and Pathological Study of Recurrent Hematuria in Childhood
Mi Jeong Kim, Jae Wook Ko, Young Jin Hong, Myung Ik Lee, Sun Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1994;37(8):1104-1110.   Published online August 15, 1994
The clinico-pathological observation was done on 28 children with recurrent hematuria, who had been admitted to the Pediatric ward of NMC from January 1981 to July 1991. The results were as follows; 1) Most of the children with recurrent hematuria were over 6 years of age (24 cases, 85.7%) and the sex ratio was about 2.5:1. 2) IgA nephropathy (17 cases, 60.7%) was...
Identification of the Source of hematuria by the Ratio of the Urinary Erythrocyte MCV to That in Blood
Young Guk Kim, Gi Chan Lee, Keun Haeng Cho, Kee Hwan Yoo, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(8):1097-1103.   Published online August 15, 1994
The frequent occurrence of hematuria in children necessitates diagnostic evaluation. Hematuria may occur with either renal or lower urinary tract disease. Clarification of the etiology of hematuria, whether microscopic or gross, is facilited by localizing the site of bleeding to the kidney(glomerular) or the lower urinary tract (non-glomerular). The mean cellular volume (MCV) of urinary red blood cells (RBCs) of...
Clinical Observation of urinary Tract Anomalies
In Hee Jung, Hong Jin Lee, Sang Joo Han, Won Il Park, Kyung Ja Lee
Clin Exp Pediatr. 1994;37(8):1092-1096.   Published online August 15, 1994
Urinary tract anomaly is the most common anomaly in childhood. We reviewed medical records of 45 patients who were confirmed urinary tract anomalies on radiologic studies as Chuncheon Sacred Hospital, from Dec. 1984 to Sep. 1992. We analyzed incidence and clinical characteristics of urinary tract anomalies. The results obtained were as follows: 1) The age distrtibution were: 17 cases (37.8%) under...
A Study on Evolution of Lipoportein(a) in Newborns
Keun Haeng Cho, Young Sook Hong, Soo Won Lee, Soon Kyum Kim, Young Chang Tockgo, Han Kyeom Kim
Clin Exp Pediatr. 1994;37(8):1078-1091.   Published online August 15, 1994
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors, together...
Incidence and Perinatal Risk Factors of Respiratory Distress Syndrome of Newborn
Yun Sil Chang, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(8):1065-1077.   Published online August 15, 1994
Over a continuous 4-year period, from January 1989 till December 1992, 7,100 infants were born in Department of Obstetrics and admitted to Nursery or Neonatal Intensive Care Unit of Department of Pediatrics of Seoul National University Children's Hospital. Among them, 126 cases were diagnosed as respiratory distress syndrome (RDS) of newborn. The total incidence of RDS among all the newborns(inborn)was 1.77%....
Morphologic Changes of Lung Parenchymal Tissue in Neonatal Rat Pups under Chronic Hyperoxia
Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(8):1055-1064.   Published online August 15, 1994
We studied the effects of chronic hyperoxia (>95% oxygen for 14 days) in change of body weight, wet to dry ling weight ratio, and morphologic changes of lung tissue compared with that of room air (21% oxygen for 14 days) in Sprague-Dawley neonatal rat pups. The results were as follows: 1) In neonatal rat pups exposed to room air (normoxia group), body...
A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro
Seong Yong Jung, Thi Hyung Park, Chong Woo Bae, Chang Il Ahn
Clin Exp Pediatr. 1994;37(8):1048-1054.   Published online August 15, 1994
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent...
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Prevalence of Diabetes Mellitus and Glycosuria in School children
Jae Ho Lee, Kwang Wook Ko
Clin Exp Pediatr. 1994;37(7):986-993.   Published online July 15, 1994
An epidemiological survey on the glycosuria was conducted on the senier students of middle and hign school in Seoul, from March 1981 to March 1982. Selected examinee totalled to 254,835 of which 138,116 were male & 116,719 were female. The initial, second and third urine sugar test were done with Combur-test strip? Glucose tolerance test was performed on those who...
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