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Original Article
Diagnostic Significance of DMSA Renal Scan and C-Reactive Protein in Urinary Tract Infection of Childhood
Sung Ho Hong, Hyang Mi Kwon, Hye Lim Jung, Dong Hyuck Kuem
Clin Exp Pediatr. 1996;39(11):1565-1575.   Published online November 15, 1996
Purpose : Renal scar or reflux nephropathy, known as a major cause of end-stage renal failure and hypertension in children and young adults, is frequently detected in pediatric urinary tract infection(UTI) patients at their first infections. So early and accurate diagnosis, and follow up of renal scar are very important. We performed this study to recognize the importance of radiologic examinations for detection of...
Caustic Esophagitis and Gastrofiberoscopy in Children
Hyeon Jeong Kim, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(11):1556-1564.   Published online November 15, 1996
Purpose : There have been many accidental ingestions of strong acid or alkali in early childhood. If the patient survives the acute effects of caustic ingestion, the reparative response can result in esophageal and gastric stenosis. However there have been few endoscopic studies on caustic esophagitis in children. The aim of this study was to review the contribution of the endoscopy to the diagnosis...
The Diagnostic Value of Liver Biopsy in Children with Fever of Unknown Origin and Hepatosplenomegaly
Sue Mee Park, Yeon Ho Choi, Jong Jae Kim, Hoan Jong Lee, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(11):1544-1555.   Published online November 15, 1996
Purpose : Although many strides have been made in the radiological and laboratory diagnosis, the liver biopsy is still considered an important tool for the diagnosis of liver disease. We report our experience that histologic investigation of the liver was essential searching for the etiologic diagnosis in eight children with fever of unknowm origin and hepatosplenomegaly, who's diagnosis were not documented by other diagnostic...
Clinical Course of the Ostium Secundum Atrial Septal Defect(ASD) and Its Rate of Spontaneous Closure
Dae Yong Kim, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1996;39(11):1538-1543.   Published online November 15, 1996
Purpose : To know the natural course of the ostium secundum ASD including its rate of spontaneous closure. Methods : We studied 259 cases who were diagnosed as ostium secundum ASD by 2D-echocardiography at Department of Pediatrics, Kyungpook National University Hospital between Jan. 1985 and Dec. 1994. According to the age at diagnosis, we divided them into two groups, group I (those diagnosed before 1...
Trend of Tuberculous Meningitis since 1970
Jeong A Park, Chang Weon Oh, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1996;39(11):1527-1537.   Published online November 15, 1996
Purpose : The incidence of tuberculous meningitis has reportedly decreased from 4.2% in 1970 to 1.8% in 1990 in Korea; however, tuberculous meningitis, which spreads hematogenously, claiming majority of mortality in childhood tuberculosis, still poses serious problems. This study was performed to evaluate the recent trend of tuberculous meningitis. Methods : We compared with three groups of tuberculous meningitis, two were our previous reports on...
Relation of Umbilical Cord Blood Insulin/C-peptide to Neonatal Anthropometric Measures in Offspring of Mother with Normal Glucose Metabolism
Sun Young Kho, Hye Kyung Han, Mi Ryung Uhm, Kyung Hoon Kim, Mi Na Lee, Hak Chul Jang, Moon-young Kim
Clin Exp Pediatr. 1996;39(11):1520-1526.   Published online November 15, 1996
Purpose : We tried to find the relationships between the fetal beta-cell function and neonatal birth weight, anthropometric measures, and maternal characteristics, and to observe role of insulin as fetal growth factor in offsprings of mothers who have normal glucose metabolism. Methods : We measured umbilical cord blood insulin and C-peptide concentrations in 236 neonates delivered at Cheil General Hospital from Jan. 1 to...
Changes in MaternalAge and the Incidence of Down Syndrome
Chang Weon Oh, Sung Su Lim, Ki Bok Kim, Won Jin Kee
Clin Exp Pediatr. 1996;39(11):1512-1519.   Published online November 15, 1996
Purpose : The incidence of Down syndrome, the most common chromosoaml anomaly, increases with the advanced maternal age. Recently, however, the incidence of Down symdrome was reported to have decreased with wide acceptance of prenatal diagnosis and planned parenthood, prompting us to re-evaluate the incidence of Down syndrome in relation to changes in maternal age. Methods : Subjected to study were 296 Down cases: 26...
Clinical Investigation of Neck Masses in Children
Sung Chul Byun, Dong Soo Kim
Clin Exp Pediatr. 1996;39(10):1429-1442.   Published online October 15, 1996
Purpose : Neck masses are frequently encountered in pediatric practice, and have various underlying diseases. If the underlying diseases of the neck mass are not confirmed by its clinical characteristics, it can be done by neck mass biopsy. To define the necessity and the appropriate time of neck mass biopsy is very difficult and also important. Therefore the authers have conducted this study to...
The Correlation between CD34+ Cell and Nucleated RBC Counts in Human Cord Blood
Seong Man Lee, Kyu Chan Kim, Sang Woo Kim
Clin Exp Pediatr. 1996;39(10):1422-1428.   Published online October 15, 1996
Purpose : Human umbilical cord blood as a potential source of hematopoietic stem cell for stem cell transplantation in children has recently been advocated. Clinical application of cord blood transplantation, however, requires adequate blood volume and number of stem cells. Currently, the number of stem cells in the cord blood is usually measured by flowcytometry, which requires strict quality control and high costs. Here,...
A Study for the Normal Serum Carnitine Levelsand the Effect of Anticonvulsants on Serum Carnitine Levels in Pediatric Age
Byeong Eui Kim, Heung Dong Kim, Churl Young Chung
Clin Exp Pediatr. 1996;39(10):1414-1421.   Published online October 15, 1996
Purpose : This study aimed to evaluate the effect of anticonvulsants on serum carnitine levels as well as normal serum carnitine levels. Methods : We measured the serum carnitine levels in 53 healthy children(34 males, 19 females) and 115 epileptic children(55 males, 60 females) receiving a various antiepileptic drugs. We assessed the effects of antiepileptic drugs on serum carnitine level together with a correlation between...
Age Related Ca, Phosphorus, Uric acid concentration in Serum & Urine and Ca/Cr ratio, Cua/Ccr & TRP
Jah In Kim, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee
Clin Exp Pediatr. 1996;39(10):1405-1413.   Published online October 15, 1996
Purpose : There are many methods for the evaluation of the renal function. The proximal tubule of the nephrons have a role of reabsorption of the materials such as water, electrolytes, glucose, amino acids, and small molecular weight protein through the glomerular filtration. Therefore if abnormality is in the proximal tubule, these materials can be changed both in serum & urine. It is very...
Diagnosis and Treatment of Fetal Cardiac Anomalies
Nam Su Kim, Myung Kul Yum, Hahng Lee, Sung Ro Jung, Jung Bae Yoo, Jae Ek Lee
Clin Exp Pediatr. 1996;39(10):1395-1404.   Published online October 15, 1996
Purpose : Fetal echocardiography is used for the prenatal diagnosis of congenital heart disease. Fetal echocardiography allows decisions to be made in advance where the fetal abnormality is not compatible with life after delivery or where early correction is required. Our fetal echocardiographic experience was analysed retrospectively to guide future clinical application. Methods : 138 mothers had fetal echocardiography from April 1992 to December...
A Study about IgG Subclasses Concentration of Chronic Cough Patient and Changes of Immunoglobulin Levels after RU 41.740 Administration
Yun Sun Choi, Yang Woo Kim, Seok Jung Yun, Hyung Ku Cho, Kee Hyuck Kim
Clin Exp Pediatr. 1996;39(10):1385-1394.   Published online October 15, 1996
Purpose : People who suffer from chronic or recurrent respiratory disease have immunoglobulin deficiency due to hypofunction of B cell. Among these immunoglobulin deficiency, it has been reported that only one or two subclass of IgG are deficient with normal quantity of IgG and IgA. Therefore it is necessary to measure IgG subclasses in chronic or recurrent respiratory infection for diagnosis. The purpose of...
The Report of the Epidemiology of Measles which Prevailed in the Kyungi-Incheon Districts from July, 1993 & June,1994
Sang Uk Moon, Sung Dong Choi, Seng Yeon Jung, Byung Kyu Seo, Won Bae Lee, Jin Han Kang, Kyung Soo Lee
Clin Exp Pediatr. 1996;39(10):1378-1384.   Published online October 15, 1996
Purpose : As a result of the development and the supply of vaccination, the epochal progress in vaccination against measles has been made. Nevertheless measles intermittent prevalence throughout the world was reported and measles prevailed throughout country in 1993 & 1994. So, we studied the epidemics of measles which prevailed in the Kyungi-Incheon districts and then evaluated the effects of the present vaccination indirectly...
Measles Hepatitis in Children
Sang Gil An, Ji Eun Wuon, Ki Moon Cha, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1996;39(10):1371-1377.   Published online October 15, 1996
Purpose : Measlesinfection in children hasbeen known to havemany complications including hepatitis. But there has been no appropriate study about measles hepatitis in children. So we studied to facilitate the understanding of measles hepatitis in children by analyzing their clinical features and laboratory findings. Methods : We investigated 164 patients who were admitted to the Department of Pediatrics, Seoul Red Cross Hospital due to measles...
The Study of Serum Aminotransferase and AST/ALT Ratio in Pediatric Patients with Acute Hepatitis
Soo Mi Jung, Chang Rang Kang, Man Taeg Oh, Jong Duck Kim
Clin Exp Pediatr. 1996;39(10):1364-1370.   Published online October 15, 1996
Purpose : Serum level of the aminotransferase is the most common test in use to assess hepatocellular injury and are sensitive test of hepatocyte necrosis, but both AST and ALT level in serum rise in a variety of hepatic disorders. Some clinical study reports that AST/ALT ratio was possible to predict prognostic outcome of infants with liver disease. We have tried to assess whether...
A Study on Mean Blood Lead and ZPP Levels of Children around Cheonan-city,Chungcheongnam-do
Hyun Mi Kim, Hae Kyung Lee, Kyeong Bae Park, Sang Chul Park, Sang Man Shin, Kyu Dong An, Byoung Kuk Lee
Clin Exp Pediatr. 1996;39(10):1358-1363.   Published online October 15, 1996
Purpose : Recent years have witness a dramatic increase in public awareness of the health risks associated with lead exposure-particularly concerning young children. The lead poisoning in children was considered a rarity, usually resulting from unique circumstances such as in appropriate use of lead-based body cosmetics or direct administration of lead-containing folk medicine or contaminated atmosphere. The increasing concern about children with lower levels...
A Study for the Expression of the N-Methyl-D-Aspartate(NMDA) Subunit 2A(NR2A)and 2B(NR2B) of Rat Hippocampal Slices in the Hypoxic State
Hee Sin Go, Woo Taek Kim
Clin Exp Pediatr. 1996;39(9):1295-1308.   Published online September 15, 1996
Purpose : Excessive amounts of glutamate are released into the extracelluar space during hypoxia/ischemia and contribute to neuronal injury through overactivation of the NMDA receptors. It will be expected that the changes of the NMDA receptors to decrease the injury are developed as a kind of defense mechanism. The NMDA receptors are composed of NR1 and NR2, and there are four NR2 subunits; NR2A,...
Clinical Course of Atrioventricular Septal Defect(AVSD) in Down and non Down syndrome
Un Seok Nho, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1996;39(9):1288-1294.   Published online September 15, 1996
Purpose : It is well known that 1/3 - 1/2 of Atrioventricular septal defect(AVSD) patients also have Down syndrome which may influence the clinical course of AVSD. To know the anatomic type of AVSD and the effect of Down syndrome on the clinical course of AVSD, we studied 37 cases( Down group: 14 cases, non Down group: 23 cases) who were diagnosed and...
A Clinical Evaluation of the Esophagogastroduodenoscopy Studies in Infants and Early Children
Won Jung Shin, Jong Won Shin, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Jung, Young Dae Kwon
Clin Exp Pediatr. 1996;39(9):1280-1287.   Published online September 15, 1996
Purpose : Even though the causes and appearance of upper gastrointestinal tract lesions vary with age, attention has seldomly been focused on the infancy and early childhood. This study aimed to provide, as basic material, the experience of esophagogastroduodenoscopy(EGD) in infants and early children. Methods : The objects were 66 patients(male 40, female 26) who underwent EGD examination in case of endoscopic indication at department...
Diagnosis of Cytomegalovirus Infection in Neonatal and Infantile Periods Using Polymerase Chain Reaction
Young Ah Lee, Kyoung Lee, In Seong Jo, Woo Gap Chung
Clin Exp Pediatr. 1996;39(9):1271-1279.   Published online September 15, 1996
Purpose : The aims of present study were to document the incidence of cytomegalovirus infection in neonatal and infantile periods especially in high-risk patients of associated infection by nested PCR of DNA from leukocytes and to evaluate the effectiveness of nested PCR in the diagnosis of congenital cytomegalovirus infection. Methods : Genomic DNA was extracted from peripheral leukocytes of 204 neonates and infants during the...
Diagnosis of Bordetella Pertussis Infections by Polymerase Chain Reaction
Mi Ran Kim, Hee Jung Kang, Hoan Jong Lee
Clin Exp Pediatr. 1996;39(9):1260-1270.   Published online September 15, 1996
Purpose : Pertussis, a respiratory tract infection caused by Bordetella pertussis, is an important cause of morbidity in children. But diagnosis of pertussis is often delayed because of late development of typical symptoms and difficulties in culture. There has been no bacteriologically confirmed case of B. pertussis infection in Korea. Lower respiratoy tract may be involved in pertussis. We performed the polymerase chain reaction(PCR)...
Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
Yon Ho Choe, Jeong Kee Seo, Jeong Hwan Yun, Hyo Seok Lee
Clin Exp Pediatr. 1996;39(9):1254-1259.   Published online September 15, 1996
Purpose : A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995. Methods : Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been...
Ten Cases of Severe Adenoviral Pneumonia in the Spring 1995
Jeong Hee Kim, Sang Il Lee, Mun Hyang Lee, I Seok Kang, Heung Jae Lee, Bo Kyung Kim, Yeon-Lim Suh
Clin Exp Pediatr. 1996;39(9):1247-1253.   Published online September 15, 1996
Purpose : In the Spring 1995, there was an outbreak of adenoviral infection, which caused four death out of ten patients with adenoviral pneumonia in our hospital. Clinical courses of ten patients with severe pneumonia were similar each other, and two were confirmed as adenoviral pneumonia by postmortem autopsy. Although not proven, we believe eight patients had adenoviral pneumonia. Therefore, we report clinical features...
Effect of Indomethacin Therapy in Prematurity with Patent Ductus Arteriosus:study of Its Effectiveness in Treatment Modality
Yun Kyeong Bae, Seong Woo Roh, Min Jeong Kim, Son Sang Seo
Clin Exp Pediatr. 1996;39(9):1239-1246.   Published online September 15, 1996
Purpose : Conventional indomethacin therapy(0.2mg/kg every 12 hours for three doses) has been used for closure of PDA. The effect of prolonged low dose of indomethacin therapy(0.1mg/kg daily for six days)had been reported in foreign country but, nothing had been reported in our country. So we attempted this study to examine effects of these two methods. Methods : Forty one infants with PDA of...
A Study on Blood Lead Levels of Children in Ulsan
Seung Gyu Park, In Gyeong Back, Chul Ju Jung, Dong Jin Lee, Gyeong Dong Jung
Clin Exp Pediatr. 1996;39(9):1231-1238.   Published online September 15, 1996
Purpose : Lead toxicity affects every organ system, most importantly, the central and periphral nervous systems, kidney, and blood. Not yet, there are not so many data about blood lead levels of children in Korea. The children residing in Ulsan have some risk exposured to lead because of air pollution resulted from rapid industrialization and some lead-using industries. So we estimated the blood lead...
Measles Specific IgG Antibody Level of Term Pregnant Women and Neonatal Umbilical Cords
Hee Yeon Park, Young Kyoo Shin, Ji Tae Choung, Young Chang Tockgo
Clin Exp Pediatr. 1996;39(9):1224-1230.   Published online September 15, 1996
Purpose : Despite appropriate preventive measures, measles outbreaks occurred in the year of 1989-1990 and 1994 in Korea. Especially, the ratio of young infantile patients below 15 months old was high in those outbreaks, and the reason was, we thought, low serum level of measles specific IgG antibody in pregnant women and low transplacental transfer rate of measles specific IgG antibody to neonate. This...
Evaluation of Chromosomal Analyses done on the Parents with Chromosomal Anomalous Children and Recurrent Abortion
Kyoung Sim Kim, Kibok Kim, Won Jin Kee
Clin Exp Pediatr. 1996;39(9):1216-1223.   Published online September 15, 1996
Purpose : To gather reference data for better genetic counseling, we have evaluated the outcomes of chromosomal analyses performed on the parents with chromosomal anomalous children and recurrent abortion in this hospital for the last 20 years. Methods : Subjected to study were 108 parents (50 fathers & 58 mothers) who had children with Down syndrome, other chromosomal and congenital anomalies, and those who...
Denver II Developmental Screening Test and Development of Seoul Children
Keun Lee
Clin Exp Pediatr. 1996;39(9):1210-1215.   Published online September 15, 1996
Purpose : 2 The Denver Developmental Screening Test (DDST) is one of the most popular developmental screening tests. Since its publication in 1967, it has been standardized in many countries and has been used internationally. The Korean version of DDST was made in 1987. After a number of concerns regarding DDST have been raised, the test was revised, restandardized and published as Denver II...
Clinical Review of Recurrent Kawasaki Disease
Jong Woon Choi, Soon Ki Kim, Byong Kwan Son
Clin Exp Pediatr. 1996;39(8):1139-1145.   Published online August 15, 1996
Purpose : The recurrence of Kawasaki disease has not been considered significant and has not been reported on literatures in Korea. Authors reviewed cases with recurrent Kawasaki disease to get informations about recurrent Kawasaki disease and to know whether there is any factor, if present, that can predict recurrence. Methods : We reviewed and analyzed the hospital records of patients with recurrent Kawasaki disease who...
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