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The Effect of Bundling on Neonatal Body Temperature
Ja Kyoung Lee, Eun Jung Kim, Hea Kyoung Lee, Young Hee Yu, Hyun Sook Lee
Clin Exp Pediatr. 1998;41(1):26-32.   Published online January 15, 1998
Purpose : Fever in newborn might be an indicator of serious bacterial infection. Differentiating environmental from disease-related temperature elevations in newborn is clinically important, because neonate with environment-related temperature elevation might be subjected to an unnecessary work-up to detect occult disease. But there are exists no consistent conclusions about environmental effect in previous literatures. We prospectively evaluated the effect of...
Effects of Early Dexamethasone Therapy in Neonatal Respiratory Distress Syndrome
Hyeon-Soo Lee
Clin Exp Pediatr. 1998;41(1):19-25.   Published online January 15, 1998
Purpose : To examine the clinical effects of early dexamethasone treatment from postnatal age of 1 week to ventilated preterm infants with respiratory distress syndrome. Methods : 14 one-week-old ventilator-dependent infants were enrolled. Seven received dexamethasone and another 7 did not receive. The doses of dexamethasone used were 0.25mg/kg twice daily for 3 days, 0.125mg/kg twice for 1 day, then 0.125mg/kg...
Serum G-CSF Level Changes in Neonatal Sepsis
Kyung Ha Ryu, Eun Ae Park, Kyung Hyo Kim, Gyung Hee Kim
Clin Exp Pediatr. 1998;41(1):12-18.   Published online January 15, 1998
Purpose : The neonate is susceptible to severe and overwhelming bacterial infections. One of the most important deficiency in the neonatal host defense system seems to be quantitative and qualitative deficiency of the myeloid and the phagocytic system. Granulocyte colony-stimulating factor(G-CSF) has been shown to induce neutrophilia and enhance mature effector neutrophil function. We examined serum levels of G-CSF in...
The Clinical Aspects of Septic Arthritis in Children
Milim Koo, Dongsoo Kim
Clin Exp Pediatr. 1997;40(12):1731-1744.   Published online December 15, 1997
Purpose : Acute septic arthritis in infancy and childhood is uncommon. Delay of diagnosis and inappropriate treatment of septic arthritis results in permanent physical sequelae. We studied the initial treatment, clinical manifestations, involved sites, and etiologic organisms of septic arthritis. Methods : We reviewed 74 patients who were diagnosed septic arthritis in Departments of Pediatrics and Orthopedic Surgery, Yonsei University College of Medicine from July 1986...
The Psychological Recognition of Asthmatic Childrenfrom Parents'Views
Nog Hong Kim, Eun Ieong Seol, Gi Hyon Jeon, Gyung Ho Lee, Mun Gi Cho, Cheoln Son
Clin Exp Pediatr. 1997;40(12):1725-1730.   Published online December 15, 1997
Purpose : Many studies showed that the asthmatic children mostly have psychosocial problem such as depression or anxiety. The object of this study is to help the asthmatic children and their family by knowing what is their mothers‘ biggest concern about their asthmatic children. Methods : We made up a questionnaire with asked the mothers by telephone. If they though asthma had a certain effect...
Effect of GCV on Neuroblastoma Cell Line Expressed by HSV-TK Gene with Retroviral Vector
Hyun Sang Cho, Chuhl Joo Lyu, Yeun Soo Kim, Tae Soo Kim, Byung Soo Kim
Clin Exp Pediatr. 1997;40(12):1719-1724.   Published online December 15, 1997
Background : Gene transfer with vectors derived from murine retroviruses is restricted to cells which are proliferating and synthesizing DNA at the time of infection. Accordingly, selective introduction of genes encoding for susceptibility to otherwise nontoxic drugs(suicide genes) into proliferating tumor may be used to treat cancer. We investigated the efficacy of in vitro transduction of neuroblastoma cell with the herpes simplex-thymidine kinase(HSV-tk) gene followed...
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
Clin Exp Pediatr. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
A Study of Serum Cytokines in Nephrotic Syndrome
Mea Young Chang, Jae Ho Lee
Clin Exp Pediatr. 1997;40(12):1701-1706.   Published online December 15, 1997
Purpose : It has been reported that patients with nephrotic syndrome have high serum IgE value and IL-4 involve in IgE synthesis, IL-6 is an autocrine growth factor for the proliferation of mesangial cells. We studied association between serum cytokines and of nephrotic syndrome. Methods : We measured serum IL-6, IL-4, IFN-Υ, CD23 in 14 children with nephrotic syndrome and 3 healthy children by...
Follow-Up Study of Urinary Tract Infection Associated with Vesicoureteral Reflux
Do Whan Kil, Jea Eun Lee, Wan Seob Kim
Clin Exp Pediatr. 1997;40(12):1692-1700.   Published online December 15, 1997
Purpose : Vesicoureteral reflux(VUR) is the major cause of urinary tract infection (UTI) in children. Prolonged untreated UTI associated with VUR may result in serious complications, such as renal scarring, renal atropy, and decreased renal function. Therefore, follow up must be continued until UTI is cured completely, to prevent of serious complication. The authors conducted this study to evaluate results of the follow-up of...
Diagnostic and Therapeutic Efficacy of Endoscopic Retrograde Cholangiopancreatography in Children
Kyung Mo Kim, Ho Soon Choi, Sung Koo Lee, Myung Hwan Kim, Chong Hyun Yoon, Dong Myung Lee
Clin Exp Pediatr. 1997;40(12):1681-1691.   Published online December 15, 1997
Purpose : Endoscopic retrograde cholangiopancreatography(ERCP) may provide more definite diagnosis, preoperative guidance, and endoscopic therapy in many children with known or suspected disorders of the pancreas and biliary tract. But the reports about the ERCP in children are rare, so this study is conducted to evaluate the indication, efficacy and safety of the ERCP in children. Methods : Twenty nine ERCPs in 19 children...
Postoperative Weight-Gain in Early Infants with Symptomatic Large Ventricular Septal Defect
Chang-Rang Kang, Hyang-Suk Yoon, Jong-Bum Choi, Soon-Ho Choi
Clin Exp Pediatr. 1997;40(12):1675-1680.   Published online December 15, 1997
Purpose : To investigate the postoperative patterns of weight-gain in early infants with ventricular septal defects(VSDs), we analyze 48 patients who received primary surgical closure of the symptomatic VSDs during 6 months of age in the period of 1993 through 1995. Methods : Forty-sixt infants met criteria for inclusion in the study. The mean follow up period was 14 months(3 to 36 months). Weight...
The Correlation between a Semi-quantitative ASO(Antistreptolysin O) Assay by Rantz-Randall and a Quantitative ASO Assay by Nephelometry
Sung-Keun Park, Seok-Hee Ahn, Jung-Woo Lee, Byoung-Soo Cho, Sung-Ho Cha, Yong-Mook Choi
Clin Exp Pediatr. 1997;40(12):1670-1674.   Published online December 15, 1997
Purpose : Accurate diagnosis and prompt treatment of infection with Streptococcus pyogenes (group A streptococci) is required as it may cause many complications, and chronic serious sequelae, acute rheumatic fever and acute glomerulonephritis. Recently, the assay methods of ASO concentration tend to be changed into quantitatively from semi-quantitative or qualitative methods in this country. We would like to know relationships and degree of concurrences between...
The Espression of Fcγ Receptors and Mac-1 in Cord and Adult Blood Monocytes and Lymphocytes and Production of Interleukin-8 by Cord and Adult Blood Mononeuclear Cells Stimulated by Lipopolysacchride
Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(12):1660-1669.   Published online December 15, 1997
Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fcmoiety of IgG(FcγR) are important in antibodymediated clearance of microbes by monocytes/macrophages and immune regulation in lymphocytes. As an approach to understanding their role in neonatal life, we have compared the constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)-by neonatal and adult blood monocytes...
The Significance of Increased Circulating Intercellular Adhesion Molecule 1(cICAM-1) in Neonatal Sepsis
Hai Lee Chung, Eun Jung Park, Young Ho An, Jin Bok Hwang, Chang Ho Han, Young Dae Kwon, Sang Gyoung Kim
Clin Exp Pediatr. 1997;40(12):1651-1659.   Published online December 15, 1997
Purpose : The early and efficient diagnosis of neonatal sepsis still remains a difficult task. Reliable laboratory test is not available yet and treatment is mainly based on the physical appearance of infants. And high number of negative blood cultures in cases of clinically diagnosed sepsis further emphasize the need for a more reliable index for early diagnosis. Intercellular adhesion molecule 1(ICAM-1) has been...
The Prevalence of A985G Mutation in Medium Chain Acyl-Coenzyme A Dehydrogenase(MCAD) Gene in Neonates Determined from Guthrie Card
Baeck Hee Lee, Hye Won Park, Moon Soo Park, Ho Jin Park, Yong Choi, Hae Il Cheong
Clin Exp Pediatr. 1997;40(12):1645-1650.   Published online December 15, 1997
Purpose : Medium chain acyl-CoA dehydrogenase(MCAD) deficiency is an autosomal recessive disoder of β oxidation of fatty acids and characterized by episodic hypoglycemia, vomiting, convulsion, encephalopathy, apnea, and sudden death related to fasting or infection resembling Reye syndrome or sudden infant death syndrome. In acute stage, mortality rate is very high and survivors have significant risk of developmental disability and chronic somatic illness. However,...
The Statistical Study of Patient with Acute Poisoning
Heung Pyo Kong, Kyoung Bae Park, Oh Kyung Lee, Kang Suh Park
Clin Exp Pediatr. 1997;40(11):1596-1602.   Published online November 15, 1997
Purpose : The incidence of infectious disease, which has been the cause of death in pediatric period, was decreased. But, the opportunistic exposure to toxic substance shows a tendency to increase. We performed this study in order to find out preventive measures and the latest inclination of acute poisoning in childhood. Methods : From January 1985 to July 1996, 88 children with acute drug...
Childhood Near-Drowning in Chinju
Hyang Ok Woo, Chan-Hoo Park
Clin Exp Pediatr. 1997;40(11):1588-1595.   Published online November 15, 1997
Purpose : Drowning is the second most common cause of accidental death in children, exceeded only by motor vehicle accidents. The purpose of the present study was to investigate the prognostic factors of near-drowning in children, such as age, sex, season, site of submersion, and initial clinical or laboratory manifestrations, and to formulate preventive strategies for decreasing injuries by drowning. Methods : Sixty-one near-drowning children...
Clinical Trial of 2g/kg/day of Intravenous Immunoglobulin Single Dose as Compared with 400mg/kg/day of Intravenous Immunoglobulin for 5days in Kawasaki Disease
Seok Hee Oh, Heung Tag Kim, Hae Jin Chech, Kyuchul Choeh
Clin Exp Pediatr. 1997;40(11):1582-1587.   Published online November 15, 1997
Purpose : Since the effect of intravenous immunoglobulin (IVIG) therapy in Kawasaki disease was reported in 1984, the combined therapy of IVIG & oral aspirin has been popular. In early period, the protocol of 400mg/kg/day for 3-5 days of IVIG had been used, but rescently, the protocol of 2g/kg/day single dose has been preferred. So authers performed a clinical study to compare th efficacies...
Immunophenotypic Analysis of Umbilical Cord Blood Stem Cells
Won Ho Kang, Tai Ju Hwang, Hoon Kook, Byung Ju Kim
Clin Exp Pediatr. 1997;40(11):1572-1581.   Published online November 15, 1997
Purpose : Since umbilical cord blood (UCB), which used to be discarded, was found to be a source of enriched hematopoietic stem and progenitor cells, basic research to elucidate characteristics of UCB hematopoietic stem cells (HSCs) and its clinical application to bedside transplantation have been attempted. Moreover, stem cell transplantation (SCT) has expanded its role, not only in hematopoietic reconstitution, but in cancer therapy,...
Role of Serum Ca and 1,25(OH)2D3 as Predictor in Bone Metabolism Abnormality by Chronic Medication of Anticonvulsant
Ho-Soo Kim, Hyun-Ho Kang, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1997;40(11):1567-1571.   Published online November 15, 1997
목 적 : 항경련제의 장기복용에 의하여 저칼슘혈증, 구루병, 골연화증 등의 골대사 이상은 성 장기 소아의 중대한 문제점이 될 수 있으므로 조기발견 및 치료가 중요하다. 이에 본 저자들은 골대사 이상의 예측을 위한 지표로서 혈청 Calcium(이하 Ca), 1,25(OH)2D3에 대하여 연구를 시행하였다. 방 법 : 경희의대 소아과에서 경련성 질환으로 진단 받고 6개월 이상 항경련제를 복용한 48 명을 대상으로 하였다. 이들중 항경련제 단독복용은 37명, 두 가지 이상의 혼합복용군은 11명 이었으며,...
Diagnostic Value of 99mTc-DMSA SPECT in Children with Urinary Tract Infection
Jae Won Choi, Sung Ho Cha, Byoung Soo Cho, Duk Yoon Kim
Clin Exp Pediatr. 1997;40(11):1559-1566.   Published online November 15, 1997
Purpose : The accurate identification of renal cortical defects in children with urinary tract infection is essential in reducing subsequent morbidity. Imaging of the kidneys with 99mTc-dimercaptosuccinic acid (DMSA) has been demonstrated as the sensitive method available for identification of renal cortical defects. Single photon emission computerized tomography(SPECT) has been suggested as a method by which the accuracy of identification of renal cortical defects can...
Endoscopic Removal of Foreign Bodies in Upper GI Tract in Children
Hae Jung Han, Sang Gil An, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1997;40(11):1552-1558.   Published online November 15, 1997
Purpose : The foreing bodies in the upper GI tract are chiefly caused by accidental swallowing and rarely provoke symptoms. It is recommended to remove the foreign bodies if they produce symptoms or remain in GI tract for long duration or complications are expected to bring about. Nowadays the development of pediatric therapeutic endoscopy enables the removal of the foreign bodies in upper GI tract...
Colonic Transit Time in Children with Recurrent Abdominal Pain
Je Woo Kim, Ki Sup Chung
Clin Exp Pediatr. 1997;40(11):1544-1551.   Published online November 15, 1997
Purpose : Recurrent abdominal pain is defined as the presence of at least three discrete episodes of pain occurring over a period of 3 or more months. The reported prevalence is high up to 15% of school aged children. Mostly the pain results from functional dysmotility of the intestine but not much studies has been done. Thus we studied segmental colonic transit time(CTT)...
Comparison of Antimicrobial Susceptibility of Nosocomial and Community-Acquired Pathogens in Children of Medium-Sized Hospital
Kil Soo Joung, Jae Kook Cha, Kon Hee Lee, Hye Sun Yoon, Wonkeun Song
Clin Exp Pediatr. 1997;40(11):1537-1543.   Published online November 15, 1997
Purpose : We evaluated the identification and antimicrobial susceptibility patterns of nosocomial and community-acquired pathogens in children of the medium-sized hospital. Methods : The 357 bacterial strains isolated from Pediatric department of Dongsan Sacred Heart Hospital were examined the species identification and antimicrobial susceptibility test during the period of March to October 1996. Results : Fifty three strains(15%) of 357 strains were nosocomial pathogens. A...
Nitroglycerin Treatment in Persistent Pulmonary Hypertension of the Newborn
Ji Sook Kim, Sung Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 1997;40(11):1529-1536.   Published online November 15, 1997
Purpose : Persistent pulmonary hypertension(PPHN) of the newborn has been treated with some vasodilators including tolazoline. But these drugs have many side effects, especially systemic hypotension . To investigate the usefulness of the nitroglycerin as a specific vasodilator with few side effects, this study was done. Methods : Nitroglycerin was administered within 1st one day after birth in 8 newborn infants who were diagnosed as...
Neonatal Facial and Cry Responses to Invasive and Non-invasive Procedures
Seon Hwa Seo, Young Pyo Chang
Clin Exp Pediatr. 1997;40(11):1520-1528.   Published online November 15, 1997
Purpose : The evaluation of pain in neonates is difficult due to their limited means of communication. The aim of this study was to determine whether the behavioral reactions of facial action and cry provoked by an invasive pain-induced procedure could be discriminated from the reactions to a noninvasive pain-induced procedure in normal full-term neonates. Methods : Thirty-six healthy full-term neonates received three pain-induced...
Influences of the Intrapulmonary R→L Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome
Yoon Hyung Park, Sei Woo Chung, Seung Baik Han, Young Se Kwon, Ji Youn Kim, Woo Sik Cheong, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 1997;40(11):1508-1519.   Published online November 15, 1997
Purpose : We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth. Methods : From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit...
Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids
Dae-Eui Hong, Kyung-Yil Lee, Ji-Whan Han, Sung-Soo Hwang, Kyong-Su Lee
Clin Exp Pediatr. 1997;40(10):1453-1457.   Published online October 15, 1997
Purpose : To evaluate the efficacy of steroid therapy on prevention of development and progression of coronary artery aneurysm in intravenous immune globulin(IVIG)-resistant Kawasaki disease, we treated three children with high dose of intravenous methylprednisolone followed by low dose oral prednisolone. Methods : We selected three children with Kawasaki disease who did not repond or who initially responded but soon developed recrudescent fever after retreatment...
The Characteristics of Febrile Neutropenia Induced by Chemotherapy
Hyung Joo Sohn, Kee Hwan Yoo, Guang Chul Lee, Sun Gyum Kim
Clin Exp Pediatr. 1997;40(10):1443-1452.   Published online October 15, 1997
Purpose : The development of fever in neutropenic cancer patients is frequently a sign of infection. Infection remains the major cause of death in the patient with cancer, primarily as a consequence of the profound alterations of normal host defences which result from the malignancy, its treatment or both. Fever in the patient with neutropenia is generally recognized as an indication of the need...
A Study on the Serum Level of Phenytoin after Intravenous Administration of Loading Dose
In Joon Seol, Young Iee Yu
Clin Exp Pediatr. 1997;40(10):1435-1442.   Published online October 15, 1997
Purpose : Phenytoin is effectively and widely used drug for the treatment of status epilepticus and patient with ongoing seizure by intravenous infusion. It is generally recommended to maintain serum concentration above 10μg/ml for the sustained effective anticonvulsant effect. This study was designed to know the optimal time to begin oral maintenance therapy after initial intravenous infusion. Methods : Total 17 patients with status epilepticus...
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