| A Study of Serum Cytokines in Nephrotic Syndrome |
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Mea Young Chang, Jae Ho Lee |
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Department of Pediatrics, Chungnam National University, College of Medicine, Taejeon, Korea |
| 신증후군에서 혈청 Cytokines에 관한 연구 |
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장미영, 이재호 |
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충남대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: It has been reported that patients with nephrotic syndrome have high serum IgE value
and IL-4 involve in IgE synthesis, IL-6 is an autocrine growth factor for the proliferation of
mesangial cells. We studied association between serum cytokines and of nephrotic syndrome.
Methods
: We measured serum IL-6, IL-4, IFN-Υ, CD23 in 14 children with nephrotic syndrome
and 3 healthy children by ELISA. And we also measured serum IgG, IgA, IgM and IgE in 14
children with nephrotic syndrome.
Results
:
1) The serum IL-4 and CD23 levels of nephrotic syndrome were significantly higher than that of
control(P < 0.01, P < 0.05 respectively).
2) There were no differences in serum IL-6 and IFN-Υ levels between control and nephrotic
syndrome.
3) The serum value of IgG in nephrotic syndrome were more decreased than that in control group.
4) The serum value of IgE in nephrotic syndrome were more increased than that in control group.
5) There was no differences in the serum values of IgA and IgM between nephrotic syndrome and
control group.
Conclusions
: The children with nephrotic syndrome had higher serum IL-4, CD23, IgE level than
healthy children. In conclusion, nephrotic syndrome is highly associated with the cytokines. I expect
that the further study of cytokines in nephrotic syndrome is useful for treatment and prediction of
prognosis of nephrotic syndrome. |
| Key Words:
Nephrotic syndrome, Cytokines, IL-6, IL-4, IFN-Υ, CD23, IgG, IgA, IgM, IgE |
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