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Original Article
Effect of CpG Oligodeoxynucleotides on Airways of Mice with Established Airways Inflammation
Hei-Won Hwang, Su-Jin Kim, Won-Duk Kim, Sung-Min Cho, Dong-Suk Lee, Sung-Min Choi
Clin Exp Pediatr. 2002;45(7):875-883.   Published online July 15, 2002
Purpose : Airways eosinophilia and increased IgE, characteristic features of asthma, result from a predominant Th2 response. In this study, we investigated the effect of CpG oligodeoxynucleotides (ODNs) on the inhibition of airways eosinophilia in mice with established airway inflammation. We also investigated the immunological mechanisms involved. Methods : Groups of BALB/c mice were sensitized intradermally with ovalbumin(OVA). At week 10,...
Detection of Helicobacter pylori by Pre-embedding Immunoelectron Microscopy -Comparison with Immunoblotting Method
Hae-Seoung Jung, Eun-Jung Kim, Eun-A Kim, Ji-Hoe Park, Jin-Su Jun, Ji-Hyoun Seo, Jae-Young Lim, Myoung-Bum Choi, Hyang-Ok Woo, Hee-Shang Youn, Gyung-Hyuck Ko, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, and Kwang-Ho Rhee
Clin Exp Pediatr. 2002;45(7):862-874.   Published online July 15, 2002
Purpose : We tried to evaluate whether the detection rate of Helicobacter pylori in gastric biopsy specimens could be improved by using pre-embedding immunoelectron microscopy. Methods : A total of 119 children who complained of upper gastrointestinal symptoms were endoscoped at the Gyeongsang National University Hospital from July, 1996 to July, 1999. Five biopsy specimens(three for urease test, one for...
Thymus Size and Its Relationship to Perinatal Diseases; Respiratory Distress Syndrome and Intrauterine Growth Retardation
Sun Mi Chung, Woo Taek Kim
Clin Exp Pediatr. 2002;45(7):855-861.   Published online July 15, 2002
Purpose : Thymus size can be affected by several factors and perinatal diseases can be estimated by its size. The purpose of this study was to search for a relationship between cardiothymic/ thoracic(CT/T) ratio and perinatal diseases such as neonatal respiratory distress syndrome(RDS) and intrauterine growth retardation(IUGR) by measuring the width of the cardiothymic shadow at the level of the...
A Clinical Characteristics of Systemic Candidiasis in Neonatal Intensive Care Unit : Comparison with Systemic Bacterial Infection
Jung Hwa Lim, Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 2002;45(7):847-854.   Published online July 15, 2002
Purpose : Long term hospitalized infants in neonatal intensive care units(NICUs) are prone to systemic infection. It is important to differentiate systemic candidiasis from systemic bacterial infection early in the course. Thus, in this study, we have compared clinical characteristics of systemic candidiasis and systemic bacterial infection, in premature low birth weight infants. Methods : Retrospective chart review of the medical...
Prevalence and Risk Factors of Candida Sepsis in Neonatal Intensive Care Unit
Ic Sun Choi, Suk Hwan Lim, Chang Yee Cho, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 2002;45(7):836-846.   Published online July 15, 2002
Purpose : With the development of neonatal intensive care and the increased use of systemic antibiotics, candida sepsis has become one of the most important causes of neonatal morbidity and mortality. The purpose of this study was to investigate the prevalence rate and its associated risk factors. Methods : We retrospectively reviewed medical records of 28 cases with candida sepsis who...
Changes in the Outcomes of Very Low Birth Weight Infants
Shung Shin Kim, Moon Hee Kim, Jae Won Shin, Sun Young Ko, Eun Kyung Lee, Yun Sil Chang, I Seok Kang, Won Soon Park, Mun Hyang Lee, Sang Il Lee, Heung Jae Lee
Clin Exp Pediatr. 2002;45(7):828-835.   Published online July 15, 2002
Purpose : The outcomes of infants weighing less than 1,500 gm(very low birth weight infant : VLBWI) reflect recent progress in neonatal intensive care. In this study, we analyzed changes over time in survival rate and morbidity of VLBWIs during the past seven years. Methods : A retrospective review of medical records was analyzed for VLBWIs admitted to the neonatal intensive...
An Epidemiologic Study of Kawasaki Disease(1987-2000) : Incidence of Coronary Artery Complication in the Acute Stage
Kyung-Yil Lee, Min-Young Park, Ji-Whan Han, Hyung-Shin Lee, Jin Choi, Kyung-Tai Whang
Clin Exp Pediatr. 2002;45(6):783-789.   Published online June 15, 2002
Purpose : We evaluated the epidemiologic characteristics and incidence of coronary artery sequele of children with KD according to treatment. Methods : We retrospectively analyzed 506 medical records of children with KD, who were admitted at Daejeon St. Mary's Hospital from Jan. 1987 to Dec. 2000. Results : The mean annual incidence was 36.1±11.1 cases per year. There was a slightly higher...
Comparison of Acute Clinical Features and Coronary Involvement in Patients with Kawasaki Disease between Those Younger and Older than One Year of Age
So Young Kim, Seong Joon Lim, Sin Weon Yun, Dong Keun Lee, Eung Sang Choi
Clin Exp Pediatr. 2002;45(6):773-782.   Published online June 15, 2002
Purpose : To identify the necessity of more reasonable diagnostic criteria and the possibility of early prediction of coronary involvement in the higher risk group, we investigated and compared clinical and laboratory findings in the acute phase and coronary involvements in those younger (n=17) and older(n=53) than one year of age in Kawasaki disease(KD). Methods : Retrospective chart reviews were performed...
Effects of Insulin Level on Dyslipidemia in Children with Simple Obesity
Jung Sub Lim, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2002;45(6):764-772.   Published online June 15, 2002
Purpose : Obesity is closely related to insulin resistance, compensatory hyperinsulinemia and dyslipidemia in adults. We identified the effect of obesity measured by BMI and insulin resistance on dyslipidemia in children and adolescents. Methods : The fasting serum insulin, glucose, total cholesterol, triglyceride, HDL- and LDL-cholesterol were measured and insulin resistance(HOMA-IR) was calculated in 35 children with simple obesity(age :...
Clinical Characteristics of Type 2 Diabetes in Children and Adolescents
Seong Yong Lee, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2002;45(6):754-763.   Published online June 15, 2002
Purpose : The incidence of type 2 diabetes in children and adolescents has been reported to increase recently. The aim of this study is to investigate the clinical features of type 2 diabetes developing during childhood and adolescent period. Methods : The medical records of 33 patients with type 2 diabetes were reviewed. We analysed clinical manifestations, demographic data, and modes...
Changes of Bone Metabolism Markers and Bone Mineral Density with Improvement of Thyroid Function in Children and Adolescents with Hyperthyroidism
Min Ho Jung, Choong Ho Shin, Sei Won Yang, Byung Churl Lee
Clin Exp Pediatr. 2002;45(6):743-753.   Published online June 15, 2002
Purpose : Dynamics of bone mineral density(BMD) and bone metabolism in children and adolescents with hyperthyroidism have not been thoroughly investigated. The aim of this study was to study how the improvement of thyroid function with antithyroid treatment influenced bone metabolism and BMD in children and adolescents with hyperthyroidism. Methods : Serum levels of osteocalcin(OC), bone-specific alkaline phosphatase(b-ALP), and carboxyterminal telopeptide...
Effect of Xanthine Oxidase Inhibitor on Cerebral Hypoxia-Ischemia in Neonatal Rats
Dae-Ho Choi, Yeon-Kyun Oh, Seung-Tak Park
Clin Exp Pediatr. 2002;45(6):732-742.   Published online June 15, 2002
Purpose : In order to evaluate the hypoxia-ischemia(H-I) induced neurotoxicity and the protective effect of xanthine oxidase(XO) inhibitor(allopurinol), cell number, cell viability, lactate dehydrogenase(LDH), protein synthesis(PS) and protein kinase C(PKC) activity were measured in cerebral neurons and astrocytes. Methods : Cytotoxic effect was measured by in vitro assay at 12-72 hours after H-I on cerebral neurons and astrocytes derived from 7-day...
Sequential Analysis of Hepatitis Be Antigen Status in Infants Born to Hepatitis Be Antigen-Positive Mothers
Eun Sook Park, Hae Kyung Lee, Chang Hee Oh, Sung Ku Kim, Hae Sun Yun, Won Keun Song, Young Ah Lee
Clin Exp Pediatr. 2002;45(6):727-731.   Published online June 15, 2002
Purpose : The objectives of this study are to evaluate the significance of HBeAg positivity in infants born to HBeAg and HBsAg positive mothers. Methods : The HBeAg status of 22 HBeAg positive, HBsAg negative infants born to HBeAg and HBsAg positive mothers from December 1996 to March 1999 were evaluated by enzyme immunoassay. Results : The number of HBsAg positive...
Nosocomial Infection in Neonatal Intensive Care Unit
Hye Jung Kwon, So Youn Kim, Chang Yee Cho, Young Youn Choi, Jong Hee Shin, Soon Pal Suh
Clin Exp Pediatr. 2002;45(6):719-726.   Published online June 15, 2002
Purpose : Neonates in neonatal intensive care units(NICU) have a high risk of acquiring nosocomial infection because of their impaired host defence mechanism and invasive procedures. Nosocomial infection result in considerable morbidity and mortality among neonates. This study was carried out to survey both the epidemiology of nosocomial infection in our NICU and the annual trends of pathogens. Methods : We...
Analgesic Effect of Sugar Solution in Infantile Colic
Jong Seok Kim, Kyung Ho Kwon, Young A Lee, Hyeon Jeong Kim, Kyun Woo Lee
Clin Exp Pediatr. 2002;45(6):712-718.   Published online June 15, 2002
Purpose : Infantile colic is one of the most commonly encountered problems, characterized by excessive crying in apparently healthy young infants within the first 3 months of life. It is commonly assumed that the infant with colic has distress and possible pain. In recent investigations, it has been found that sucrose has an analgesic effect in newborn infants. The purpose...
The Ewha Infant Develomental Screening Test
Keun Lee
Clin Exp Pediatr. 2002;45(6):700-711.   Published online June 15, 2002
Purpose : Early identification and treatment of developmental disabilities is of considerable importance in the health care of children. Screening of development is aimed at identifying infants who may need more comprehensive evaluations. Methods : A new test, the Ewha Infant Development Screening Test(EDST) has been created to screen the development of infants, 0-4 years of age. EDST was constructed so...
A Change of Adrenal Androgen and Cortisol in Kawasaki Disease
Sun-Hee Lee, Jae-Hong Yu, Hong-Ryang Kil
Clin Exp Pediatr. 2002;45(5):654-658.   Published online May 15, 2002
Purpose : Endocrine and immune systems are connected and interdependent. Adrenal glands play an important role in this network and control the balance between serum levels of dehydroepiandrosterone sulfate(DHEAS) and cortisol. These steroids have an antagonistic effect on the T cell progression into Th1 and Th2 cells and on the induction of correlated interleukins. Therefore we evaluated the role of...
Type 2 Diabetes Mellitus in Children
Jee Min Park, Eun Gyong Yoo, Duk Hee Kim
Clin Exp Pediatr. 2002;45(5):646-653.   Published online May 15, 2002
Purpose : The incidence of type 2 diabetes mellitus in children has been increasing worldwide recently, which is thought to be related to the increasing prevalence of obesity. We investigated to evaluate the incidence and the characteristics of type 2 diabetes mellitus in children and also analysed the relationship between intrauterine growth retardation and type 2 diabetes mellitus. Methods :...
A Study of Receptor Expression in Leukocytes by Quantitative Fluorescence Measurement
Kyung Hyo Kim, Ju Young Seoh
Clin Exp Pediatr. 2002;45(5):637-645.   Published online May 15, 2002
Purpose : It is well known that the receptors for Fcγ moiety of IgG(FcγR) are instrumental in antibody-mediated clearance of microorganisms by granulocytes and monocytes, and immune regulation in lymphocytes. Furthermore, complement receptor-3(CR3) is also important in neutrophilic adhesion, diapedesis, and phagocytic functions. In an attempt to examine their roles in neonates, we compared the expressions of FcγRs and CR3...
Characteristics of Seizures and Neuronal Nitric Oxide Synthase Expression of Hippocampus in Hyperthermia-Induced Seizures of Developing Rat
Doo-Kwun Kim, Dong-Keun Jung
Clin Exp Pediatr. 2002;45(5):629-636.   Published online May 15, 2002
Purpose : Our study was aimed to investigate the characteristics of seizures as well as to determine whether the expression of neuronal nitric oxide synthase expression(nNOS) of hippocampus has an affect in the hyperthermic seizure in developing rat. Methods : Hyperthermic seizures were repeatedly induced twice a week for four weeks in 20-day old Spraque-Dowley rats. Fifty two rats were used...
Clinical Manifestation and Associated Cardiac Anomalies of Dextrocardia
Sung Hoon Kim, Seung A Hong, Yoon Jung Cho, Sang Lak Lee, Tae Chan Kwon
Clin Exp Pediatr. 2002;45(5):622-628.   Published online May 15, 2002
Purpose : The purpose of this study is to ascertain the clinical manifestations and associated cardiac anomalies of dextrocardia. Methods : Twenty-four pediatric patients, who were admitted to, or visited, Dongsan Medical Center Keimyung University and were diagnosed with dextrocardia between January 1996 and July 2001, were enrolled in this study. All patients received echocardiogram and abdominal ultrasonogram to identify...
Study of Neonatal Cardiac Catheterization for Over the Last 10 Years
Jinyoung Song, Sungkyu Lee, Jaeyoung Lee, Sujin Kim, Wooseup Shim
Clin Exp Pediatr. 2002;45(5):615-621.   Published online May 15, 2002
Purpose : The neonatal cardiac catheterization and angiogram for transcatheter therapy are still essential methods in congenital heart disease, so we reviewed our experience with neonatal cardiac catheterization over 10 years at a single institution. Methods : A retrospective review of all 139 neonatal catheterizations from January 1991 to December 2000 at Sejong Heart Institution was performed. The purpose of the...
Natural Course of Atrial Septal Defect Diagnosed Within the First 4 Weeks of Life
Young Jun Hwang, Kyung Hyun Chung, Suk Min Choi, Kyu Hyung Lee
Clin Exp Pediatr. 2002;45(5):609-614.   Published online May 15, 2002
Purpose : The purpose of our investigation was to explore the natural course, and the factors that influence the natural course, in ostium secundum atrial septal defect(ASD) diagnosed within the first 4 weeks of life. Methods : We studied patients with ASD diagnosed within the first 4 weeks of life during the period from September 1995 to September 1999 in our...
Epidemiologic and Clinical Features of Pertussis in Children(2000. 3-2001. 3)
Shin Yoo, Kyong Ouk Ahn, Eun Hye Park, Hyun Sang Cho, Chong Young Park, Hae Ran Lee
Clin Exp Pediatr. 2002;45(5):603-608.   Published online May 15, 2002
Purpose : Pertussis is a highly communicable infectious disease in children with high mortality, especially in young infants. The incidence of pertussis in South Korea has decreased to about 10 cases a year in late '90s. Doubting previously reported incidences of pertussis, we designed this study to establish exact epidemiology and a diagnostic basis of pertussis. Methods : From Mar. 2000...
Peripheral Neutrophil Count and Respiratory Failure in Preterm Infant
Kum Joo Lee, Soo Young Yun, Ran Lee, Jae Ho Hean, Ghee Young Jung, Jin Hee Park, Young Sun Park
Clin Exp Pediatr. 2002;45(5):596-602.   Published online May 15, 2002
Purpose : The purpose of this study was to analyze the association of peripheral neutrophil count with the development of respiratory failure in preterm infants. Methods : A retrospective study was conducted from January 1993 to December 1999 on 44 preterm infants, who were admitted to the neonatal intensive care unit of St. Francisco hospital. Preterm infants(birth weight 500 to 1,350...
Effects of Obesity on Pulmonary Functions in Children
Seok Won Park, Hwang Min Kim, Jong Soo Kim, Jae Kuk Cha, Hae Ran Lee
Clin Exp Pediatr. 2002;45(5):588-595.   Published online May 15, 2002
Purpose : The incidence of obesity has increased in Korea recently. Obesity leads to higher risks of hypertension, hyperlipidemia and insulin resistance. It also leads to risks of respiratory complications. This study was performed to see the effects of obesity on children's pulmonary functions and on developed bronchospasm after exercise loading according to their obesity degrees. Methods : 257 obese...
A Survey on the Understanding of Breast-feeding in Pregnant Woman
Jeong Wan Seo, Yong Joo Kim, Kee Hyoung Lee, Jae Young Kim, Jay G Sim, Hae Soon Kim, Jae Sung Ko, Sun Hwan Bae, Hye Sook Park, Beom Soo Park
Clin Exp Pediatr. 2002;45(5):575-587.   Published online May 15, 2002
Purpose : To investigate the understanding of breast-feeding in pregnant woman and the proper way of encouraging breast-feeding. Methods : Each questionnaire included items about demographic characteristics and the understanding of breast-feeding. The questionnaires were filled up by pregnant women visiting obstetric clinics in Seoul and its vicinities, Busan, Choongjoo and Chungjoo from July 2001 to August 2001. One thousand, two...
Radiographic Findings and Atelectasis in Children Admitted to Hospital with Acute Asthma
Yoo-Jin Jung, Hye-Jin Jung, Kyung-Yil Lee, Won-Bae Lee, Dong-Hurn Yang
Clin Exp Pediatr. 2002;45(4):519-523.   Published online April 15, 2002
Purpose : We aimed to evaluate the abnormalities of chest radiographs including atelectasis in children who were admitted with bronchial asthma. Methods : We retrospectively analyzed the 357 chest radiographs and the clinical and laboratory features of the 144 children with asthma, who were admitted at Daejoen St. Mary's Hospital from April 1994 to May 1998. Results : Clinical and laboratory...
Clinical Studies of Cerebral Palsy
Won Sik Kang, Kyong Whoon Cheon, Byeong Hee Son, Sung Won Kim
Clin Exp Pediatr. 2002;45(4):512-518.   Published online April 15, 2002
Purpose : Cerebral palsies are the most common and severe motor disabilities in childhood. There is currently increased interest in their occurrence and patterns of likely cause for a variety of reasons. Therefore, a retrospective study was carried out to understand the clinical features of cerebral palsy. Methods : A retrospective chart review was conducted of all children with cerebral palsy...
Changes in Mean Platelet Volume and Platelet Distribution Width after Therapy in Childhood Idiopathic Thrombocytopenic Purpura
Jong Tai Kim, Kyung Won Lee, Soon Nam Kim, Moon Kyu Kim
Clin Exp Pediatr. 2002;45(4):505-511.   Published online April 15, 2002
Purpose : Mean platelet volume(MPV) and platelet distribution width(PDW) are useful parameters in evaluating disorders of platelets. In cases with idiopathic thrombocytopenic purpura(ITP), they change as platelet count increases. In this study, we compared the values of MPV and PDW in ITP patients at diagnosis with those of normal children. We also studied whether the early changes in MPV may...
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