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Risk Factors of Nephrocalcinosis in Very Low Birth Weight(VLBW) Infants
Gyu Hong Shim, Jin A Lee, Yun Jung Shin, Ee Kyung Kim, June Dong Park, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2004;47(3):275-281.   Published online March 15, 2004
Purpose : Nephrocalcinosis in very low birth weight(VLBW) infants were known to be caused by a longer duration of furosemide use. However, etiologies, pathogenesis and risk factors remain unclear. Therefore, we examined the incidence and risk factors of nephrocalcinosis in VLBW infants retrospectively. Methods : Inborn babies of birth weights less than 1,500 gm were examined retrospectively. Data were reviewed on...
The Effect of Post-natal Weight Changes on the Development of Bronchopulmonary Dysplasia in Infants with Respiratory Distress Syndrome
Hye One Jhon, Young Min Kim, Hee Joo Hong, Chong Woo Bae
Clin Exp Pediatr. 2004;47(3):269-274.   Published online March 15, 2004
Purpose : The subjects were compared and measured for differences in the aspects of weight changes between the groups that developed bronchopulmonary dysplasia(BPD) after treatment and those that did not, to analyze the relations between the patterns of early weight change after birth and the development of BPD. Methods : Retrospective analysis of medical records were performed for birth weight and...
Observation on Causes of Adoption and Social Background of Children in Adoption Institution(5th Report)
Hak Sung Kim, Soo Yeon Kim, Sun Hee Kong, Dong Woo Lee, Kyung Eun Kim, Hye Jung Shin, Jae Yoon Kim
Clin Exp Pediatr. 2004;47(3):264-268.   Published online March 15, 2004
Purpose : Through a review of data provided by an adoption institution, this study was designed to provide a clue to help to reduce the abandonment of children by comparing the conditions at birth, social background, reason for request for adoption, and the degree of dependence on foreign adoption compared with the previous four reports. Methods : A total of 445...
The Relationship between the Perception of Height and Self-Esteem in Children
Mi Jin Kim, Young Il Rho, Eun Seok Yang, Kyung Rye Moon, Sang Kee Park, Yeong Bong Park, Eun Young Kim
Clin Exp Pediatr. 2004;47(3):258-263.   Published online March 15, 2004
Purpose : The aim of this study was to evaluate the behavioral and affective characteristics of children who thought they were short. Methods : Fifteen hundred and twenty-two students of four elementary and middle schools in Gwangju City completed a battery of questionnaires asking about stature-related stress, self-esteem, and personality characteristics. The children were divided into three groups and compared according...
Trend of Obesity in School Age Children in Seoul Over the Past 23 Years
Young Shin Park, Dong Hwan Lee, Joong-Myung Choi, Yun Ju Kang, Chong Hee Kim
Clin Exp Pediatr. 2004;47(3):247-257.   Published online March 15, 2004
Purpose : The aim of this study was to evaluate the change in prevalence and the epidemiology of obesity in school age children of Seoul, Korea during the last 23 years with coherency and under the same standards. Methods : We used the new 1998 standard weight for height to calculate obesity on the personal data from five years and produced...
Effects of 7-Nitroindazole on Brain Cell Membrane Function and Energy Metabolism during Transient Global Cerebral Hypoxia-Ischemia and Reoxygenation-Reperfusion in Newborn Piglets
Chang Won Choi, Jong Hee Hwang, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2004;47(2):204-209.   Published online February 15, 2004
Purpose : Our study was undertaken to discover whether a selective neuronal nitric oxide synthase inhibitor, 7-nitroindazole, influences brain cell membrane function and energy metabolism during and after transient global hypoxia-ischemia(HI) in newborn piglets. Methods : Cerebral HI was induced by temporary complete occlusion of bilateral common carotid arteries and simultaneous breathing with 8% oxygen for 30 minutes, followed by release...
Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
Clin Exp Pediatr. 2004;47(2):193-203.   Published online February 15, 2004
Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and...
Ultrasonographic Bladder Parameters for Successful Suprapubic Bladder Aspiration
Sung Chul Baek, Hoe Kyoung Koo, Cheol Hong Kim, Kyung Bum Kim, Hyun Hee Lee, Byung Min Choi, Kee Hwan Yoo, Young Suk Hong, Dong Gwan Han
Clin Exp Pediatr. 2004;47(2):187-192.   Published online February 15, 2004
Purpose : Suprapubic bladder aspiration(SBA) is a widely accepted method of obtaining sterile urine for culture in neonates but has a relatively low success rate and a few serious complications during SBA procedure. To improve the chance of obtaining urine, we determined the ultrasonographic bladder parameters(diameters and volume) to confirm that the bladder is adequately distended for successful aspiration of...
The Prevalence of Transfusion-Transmitted Virus Infection in Children
Ju Young Chung, Tae Hee Han, Eung Su Hwang
Clin Exp Pediatr. 2004;47(2):183-186.   Published online February 15, 2004
Purpose : Transfusion-transmitted virus(TTV) is an newly described nonenveloped human virus, with a circular, negative stranded DNA genome. Although a high prevalence of TTV infection in the normal population has been demonstrated, there is a still possibility of association with hepatitis according to the genotype of TTV. The aim of this study is to investigate the prevalence of TTV infection...
An Epidemiological Study on Refractory Enterobiasis
Hyea Sook Ryue, Jo-Won Jung, Ki-Soo Pai
Clin Exp Pediatr. 2004;47(2):177-182.   Published online February 15, 2004
Purpose : In order to render substantial solutions to control the refractory enterobiasis, factors were evaluated which were associated with treatment failure in Enterobius vermicularis infestation. Methods : An epidemiological study was done in 20 patients with refractory entrobiasis and in 107 preschoolers as a control. The possible symptoms and hygienic habits which may associated with entrobiasis were surveyed by questionnaires. Results...
Serum ECP, RANTES and Eotaxin Levels in Infants with Bronchiolitis
Jong Seo Yoon, Mi Hee Lee, Joon Sung Lee
Clin Exp Pediatr. 2004;47(2):170-176.   Published online February 15, 2004
Purpose : Viral respiratory infection, especially respiratory syncytial(RS) virus, can predispose sufferers to the development of asthma by mechanisms that are presently undetermined. The role of inflammatory mediators in pathogenesis of asthma and RS virus disease is not well-understood. We investigated the performance of serum eosinophil cationic protein(ECP), regulated on activation normal T-cell expressed and secreted(RANTES) and eotaxin levels on...
Risk Factors of Urinary Tract Infections Due to Extended-spectrum β-lactamase Producing Escherichia coli in Children
Nam Hee Kim, Jin A Lee, Yun Kyung Kim, Eun Hwa Choi, Il Soo Ha, Hoan Jong Lee, Yong Choi
Clin Exp Pediatr. 2004;47(2):164-169.   Published online February 15, 2004
Purpose : This study was performed to identify risk factors for urinary tract infection(UTI) by extended-spectrum β-lactamase(ESBL)-producing Escherichia coli in children. Methods : We analyzed 125 episodes of UTI which were developed in 112 children at the Seoul National University Children's Hospital from July to December 2002. Medical records of 74 episodes of UTI caused by E. coli were reviewed in...
A Clinical Study on Mental Retardation of Preschool Children Diagnosed in Pediatric Developmental Clinic
Young Yeui Kim, In Kyung Sung
Clin Exp Pediatr. 2004;47(2):157-163.   Published online February 15, 2004
Purpose : Mental retardation, which can be defined as subnormal cognitive ability with markedly decreased ability to adapt to one's environment, is a common developmental disorder. But the diagnosis of mental retardation in young children is frequently missed in pediatric clinics. The purpose of this study is to increase the rate of early diagnosis and intervention by providing clinical information...
The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants
Heui seung Jo, Beyong Il Kim, Chang Won Choi, Jun Dong Park, Chong Jai Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2004;47(2):150-156.   Published online February 15, 2004

Purpose: Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants. Methods: Clinical data were collected retrospectively from 478 preterm infants(gestational period≤34 weeks) who were admitted to the neonatal...
Alteration of Bone Metabolism Markers According to the Progression of Puberty
Seong Yong Lee, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2004;47(2):140-149.   Published online February 15, 2004
Purpose : The object of this study is to evaluate bone metabolism in healthy adolescents according to the progression of puberty. Methods : Forty boys(13.9?.7 years) and 42 girls(12.1?.6 years) were classified by Tanner stage (TS) and bone age. Serum levels of osteocalcin(OC) and bone specific alkaline phosphatase(BALP) were measured as bone formation markers. Serum level of C-terminal telopeptide of type...
Prediction of Intravenous Immunoglobulin Non-responders in Patients with Kawasaki Disease
Gi Bum Lee, Ji-Won Lee, Kyung-Yil Lee
Clin Exp Pediatr. 2004;47(1):90-94.   Published online January 15, 2004
Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on the levels of laboratory indices examined serially according to the responsiveness to IVIG therapy in children with Kawasaki disease(KD). Methods : Children with KD(n=63) who had been treated with IVIG at a dosage of 2.0 g/kg were classified into two groups : the IVIG-resistant(consistent fever over 48 hours after initiation...
Comparison of Serum Proteome Maps of Children with Kawasaki Disease
Seoung Yon Baek, Young-Mock Lee, Kwang Hoon Lee, Dong Soo Kim
Clin Exp Pediatr. 2004;47(1):81-89.   Published online January 15, 2004
Purpose : Kawasaki disease is a systemic vasculitis observed in children under five years of age and the leading cause of pediatric acquired heart disease, but its pathophysiology is still not completely understood. With proteomics, the study of quality and quantity of proteins, having been developed dramatically, we tried to find a way to evaluate the etiology and pathogenesis of...
Clinical Characteristic of Chronic Autoimmune Thyroiditis in Children
Hye Rim Chung, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2004;47(1):76-80.   Published online January 15, 2004
Purpose : Although chronic autoimmune thyroiditis(AIT) is known to progress into overt hypothyroidism in adults, the outcomes of this disorder in pediatric patients are different from those in adults, so it is hard to predict its course. We reviewed clinical characteristics of chronic AIT in children. Methods : The medical records of 94 children, who were diagnosed as AIT, were analyzed,...
Outcome after Discontinuation of Antiepileptic Drugs in Well Controlled Epileptic Children - Recurrence and Related Risk Factors
Hyo-Bin Kim, Su Jeong You, Tae-Sung Ko
Clin Exp Pediatr. 2004;47(1):66-75.   Published online January 15, 2004
Purpose : There has been no exact criteria established for when to discontinue antiepileptic drugs (AEDs) in epileptic children who had been well controlled for a long period. This study was undertaken to evaluate the recurrence rate and predictive risk factors of relapse after discontinuation of AEDs in epileptic children who had been seizure-free. Methods : We retrospectively studied 294 children...
Clinical Experience of 60 Pediatric Renal Transplantations at a Single Center
Sun Youn Lee, Hyewon Han, Young Seo Park, Duck Jong Han
Clin Exp Pediatr. 2004;47(1):55-65.   Published online January 15, 2004
Purpose : Renal transplantation for the management of end-stage renal disease(ESRD) in children is now the optimal treatment. We analyzed the clinical courses and characteristics of pediatric renal transplantation in Asan Medical Center. Methods : We reviewed the charts of 60 cases of renal transplantation under the age of 18, admitted to Asan Medical Center, from Oct. 1990 to May 2003....
Abnormality of Regional Wall Motion of the Left Ventricle in Children with Ventricular Diastolic Overload
Yeo Hyang Kim, Sang Bum Lee
Clin Exp Pediatr. 2004;47(1):49-54.   Published online January 15, 2004
Purpose : To assess the regional wall motion of the left ventricle in patients with diastolic overloaded lesions of congenital heart diseases with centerline analysis and radial method. Methods : This study included 96 children with congenital heart diseases admitted to Kyungpook National University Hospital from January 1998 to December 2002 who received left ventriculograms. The evaluation of the regional wall...
Pulmonary Venous Flow Doppler Pattern in Infant Atrial Septal Defect Cases
Kyung Shin Rhee, Youngshin Park, Jeong Jin Yu, Chang Hwi Kim
Clin Exp Pediatr. 2004;47(1):44-48.   Published online January 15, 2004
Purpose : Doppler findings of pulmonary venous flow in large atrial septal defect(ASD) has been known to show a contiguous form rather than showing a form with two peaks in a cardiac cycle. The aim of this study was to find out the affecting variables in flow pattern change. Methods : The present study was conducted on 16 isolated secondum ASD...
Mid-term Result of the Transcatheter Occlusion of Patent Ductus Arteriosus with Duct-Occlud Device and Procedure-Related Problems
Yuria Kim, Jae Young Choi, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee, Young Hwan Park, Bum Koo Cho
Clin Exp Pediatr. 2004;47(1):36-43.   Published online January 15, 2004
Purpose : We will present our mid-term result of transcatheter closure of PDA with Duct-Occlud device(pfm. AG. Germany) after 12 months follow up and report the problems during the procedure. Methods : In total 154 patients, the Duct-Occlud devices were inserted in our institute from March, 1996 to August, 2002. Three types of Duct-Occlud device, i.e standard, reinforced, reinforced reverse cone...
Clinical Observation of Mesenteric Lymphadenitis in Children
Chul Han Park, Dong Hoon Lee, Hye Lim Kim, Ji Min Park, Jin Bok Hwang, Heung Sik Kim, Hee Jung Lee
Clin Exp Pediatr. 2004;47(1):31-35.   Published online January 15, 2004
Purpose : Mesenteric lymphadenitis is classified into acute and chronic, specific and nonspecific types according to clinical aspect and causative disease. We under took this study to find out clinical aspects, associated diseases and hospital course of mesenteric lymphadenitis in children. Methods : We examined 98 children aged from 18 months to 14 years who visited Dongsan Medical Center for abdominal...
Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002
Sung Seok Kim, Hoon Kang, Byung Moon Ahn, Won Wook Lee, Eun Ryoung Kim, Soo Yeon Kim, Hyun Pil Cho
Clin Exp Pediatr. 2004;47(1):24-30.   Published online January 15, 2004
Methods : We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification...
Polymorphism of UDP-glucuronosyltransferase Gene(UGT1A1) of Neonatal Hyperbilirubinemia in Korea
Ki Woong Hong, Hoon Kang, Soo Kim, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Sheng-Yu Jin, Joo Ho Chung
Clin Exp Pediatr. 2004;47(1):18-23.   Published online January 15, 2004
Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in whites and its metabolic basis has not been clearly explained. Recently, UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia in Japanese and Taiwanese Chinese. We studied whether neonatal hyperbilirubinemia is associated with mutation of UGT1A1, which is a...
Clinical Analysis of Pediatric Death Patients Visiting Emergency Center
Do Hyun Kim, Seong Hun Lee, Sang Bae Lee, Min Hyuk Ryu, Dong Jin Lee
Clin Exp Pediatr. 2004;47(1):12-17.   Published online January 15, 2004
Purpose : We analyzed pediatric death patients who visited Dong-Kang Hospital emergency center, in order to minimize unexpected pediatric deaths. Methods : The authors analyzed retrospectively the medical records of 110 pediatric patients who died before and within 24 hours after admission to the emergency center of Ulsan Dong-Kang General Hospital from January 1997 to December 2002. Results : We classified three...
Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia
Jie Yeon Lee, Sue Youn, Byoung Chul Kwon, Chuhl Joo Lyu, Hwang Min Kim
Clin Exp Pediatr. 2003;46(12):1260-1265.   Published online December 15, 2003
Purpose : In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs....
Clinical Characteristics and Prognosis of Neonatal Seizures
Chang Wu Kim, Chang Hwan Jang, Heng Mi Kim, Byung Ho Choe, Soon Hak Kwon
Clin Exp Pediatr. 2003;46(12):1253-1259.   Published online December 15, 2003
Backgroud : Seizures in the neonate are relatively common and their clinical features are different from those in children and adults. The study aimed to provide the clinical profiles of neonatal seizure in our hospital. Methods : A total of 41 newborns with seizures were enrolled in this study over a period of three years. They were evaluated with special reference...
Clinical Evaluation and Diagnosis of Children with Chest Pain
Su A Shin, Yong Joo Kim, Jae Whan Lee, Nam Su Kim, Soo Ji Moon
Clin Exp Pediatr. 2003;46(12):1248-1252.   Published online December 15, 2003
Purpose : Chest pain in the pediatric population is not rare and mostly benign. Causes of chest pain are diverse, and differential diagnosis is not easy. Chest pain in children is less likely to be cardiac in origin. Furthermore, chest pain in the pediatric population is rarely associated with life-threatening disease. This study was designed to evaluate children with chest...
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