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Original Article
Interpretation of Traumatic Lumbar Puncture in Aseptic Meningitis
Su Jin Sung, Jung Kim
Clin Exp Pediatr. 2004;47(5):543-546.   Published online May 15, 2004
Purpose : This study was undertaken to find out a useful method that can predict the true leukocytosis in blood-contaminated cerebrospinal fluid(CSF) due to traumatic lumbar puncture(LP), using white and red cell counts of sanguineous CSF and peripheral blood. Methods : From May 2001 to December 2002, among 1,247 patients presenting symptoms of meningitis who had received LP at Chonnam Hospital,...
A Clinical Study and Sonographic Findings of Neonatal Adrenal Hemorrhage
Ok Yeon Cho, Kyoung Eun Lee, Eun Jung Shim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Sub Lee
Clin Exp Pediatr. 2004;47(5):535-542.   Published online May 15, 2004
Purpose : This study was performed to present out experience of neonatal adrenal hemorrhage (NAH) and to help diagnosis and management of NAH. Methods : We conducted a retrospective study on 14 neonates diagnosed as NAH from January 1993 to August 2002 at Hallym Medical Center. Their clinical manifestations, risk factors, sonographic findings and progression of NAH were evaluated using...
Renal Anomalies in Neonates with Isolated Preauricular Tags
Myung Eun Hong, Seung Taek Yoo, Eun Jung Choi, Chang Woo Lee, Seung Taek Park, Yeon Kyun Oh
Clin Exp Pediatr. 2004;47(5):532-534.   Published online May 15, 2004
Purpose : The aim of this study was to determine the role of renal ultrasonography in neonates with isolated preauricular tags. Methods : We performed a retrospective study of 10,997 newborn infants delivered from January 1995 to June 2003 in Wonkwang University Hospital. Nineteen newborns born with isolated preauricular tags were assessed for renal anomalies by performing renal ultrasonography within one...
Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia
In Sook Yang, Jung Hyun Lee, Hyung Shin Lee, So Young Kim, Sung Dong Choi, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2004;47(5):527-531.   Published online May 15, 2004
Purpose : This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia. Methods : Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and...
Prevention of Chronic Lung Disease with Early Dexamethasone Treatment in less than 32 Weeks Premature : Randomized Controlled Study
So Yun Shim, Su Jin Cho, Eun Ae Park
Clin Exp Pediatr. 2004;47(5):521-526.   Published online May 15, 2004
Purpose : The optimal timing and the consequences of dexamethasone therapy in chronic lung disease remain unknown. The purpose of this study was to determine whether early dexamethasone therapy would reduce the incidence of chronic lung disease and to determine the adverse effects and complications of prematurity associated with such therapy. Methods : Twenty neonates with hyaline membrane disease(dexamethasone n=10, placebo...
Cytokines in Neonatal Sepsis
Hye Jin Park, So Yeon Kim, Jun Hwa Lee, Eun Jin Choi, Jin Kyung Kim, Sang Gyung Kim, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2004;47(5):515-520.   Published online May 15, 2004
Purpose : Maternal premature rupture of membrane(PROM) over 24 hours is a risk factor in neonatal sepsis and a main cause of administration to neonatal intensive care unit. Levels of proinflammatory cytokines were studied to diagnose and treat early in newborn infants with sepsis and with a history of maternal PROM. Methods : Interleukin-1β(IL-1β), Interleukin-6(IL-6), Interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) were...
Incidence and Risk Factors of Rehospitalization with Respiratory Syncytial Virus Infection in Premature Infants
Eun Ah Lee, Jea Heon Jeong, Seung Taek Yu, Chang Woo Lee, Hyang Suk Yoon, Do Sim Park, Yeon Kyun Oh
Clin Exp Pediatr. 2004;47(5):510-514.   Published online May 15, 2004
Purpose : We performed this study to evaluate the risk of rehospitalization for respiratory syncytial virus(RSV) infection among premature infants discharged from a neonatal intensive care unit(NICU). Methods : We performed a retrospective study for rehospitalization for RSV infection and risk factors among premature infants who were admitted to NICU and discharged between May 2001 and April 2003 in Wonkwang...
Survival Rate in Very Low Birth Weight Infants
Jae Ju Cho, Soon Bum Lee, Woo Sung Park, Young Pyo Chang
Clin Exp Pediatr. 2004;47(5):505-509.   Published online May 15, 2004
Purpose : We observed changes in the outcome of very low birth weight infants(VLBWI) admitted to the neonatal intensive care unit(NICU) of Dankook University Hospital(DKUH) in the last six years. Methods : The distribution of birth weight and gestational age, survival rate, neonatal complications, and causes of death for 228 VLBWI who had been admitted to DKUH from 1st January...
The Relationship between Developmental Quotient in Children with Delayed Language Development and Later Intellectual Quotient
So Yeon Kim, Yeon Kyung Jung, Hai Lee Jung, Woo Taek Kim, Im Hee Shin, Jung Han Park, Heng Mi Kim, Jin Kyung Kim
Clin Exp Pediatr. 2004;47(5):496-504.   Published online May 15, 2004
Purpose : The objective of this study was to test the predictive validity of developmental test for later intellectual development in young children with delayed language development. Methods : The study subjects were 66 children who had presented delayed language development and had an initial developmental test and a follow-up intelligence test. The mean age at initial test was 34.2 months(17-48...
Correlation between Percentage of Body Fat by BIA and Other Obesity Indices
Su Jin Kim, Su Yung Kim
Clin Exp Pediatr. 2004;47(5):491-495.   Published online May 15, 2004
Purpose : Obesity is becoming a serious health problem in schoolage children and adolescents. There are several parameters to estimate obesity such as body mass index(BMI), skinfold thickness, obesity index and weight for height. Each parameter has some advantages and disadvantages. Bioelectrical impedance analysis(BIA) seems to be a simple, reproducible, objective and cost effective method for fat evaluation. But there...
Correlation of Measurements for Body Fat in Obese Children
Jong Hoon Kim, In Seok Lim
Clin Exp Pediatr. 2004;47(5):485-490.   Published online May 15, 2004
Purpose : Measurement of body fat in obese children is useful not only in evaluating health hazard but also in establishing standards of treatment and evaluating the effectiveness of treatment. In the field of clinical and laboratory study, there are various methods with different reliability, propriety, convenience, and expenses. However, the practical value of these studies is limited in Korea,...
Expression of Fibroblast Growth Factor Receptors at Different Stages of Differentiation in Chick Embryo Chondrocytes
Jo Young Suh, Jong Eul Park, Woo Taek Kim
Clin Exp Pediatr. 2004;47(4):439-447.   Published online April 15, 2004
Purpose : Proliferative chondrocytes and prehypertrophic chondrocytes secrete significant amounts of type II collagen in an extracellular matrix. In contrast, hypertrophic chondrocytes secrete type X collagen. In addition, fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) also appear to play an important role during differentiation. Accordingly, the current study identified and characterized the chondrocytes and FGFR mRNA expressed...
Phenotypic Transformation of Tubular Epithelial Cells and Fibroblasts Following Unilateral Ureteral Obstruction or Angiotensin II Infusion in the S-D Rat
Eui Seong Lee, Min Jee Jeoung, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2004;47(4):430-438.   Published online April 15, 2004
Purpose : Unilateral ureteral obstruction(UUO), a well established experimental model of renal injury, gives rise to tubulointerstitial fibrosis, tubular dilatation and cellular atrophy. Angiotensin(ANG) II may take the prime role in the regulation of this response. The objectives in the current investigation were to determine whether the renal response to UUO involves the dedifferentiation of tubular epithelial cells to mesenchymal...
Manifestation of Coronary Artery Lesions after Immunoglobulin Re-treatment in Initial Immunoglobulin-resistant Kawasaki Disease
Hyo Jung Suk, In Sung Kim, Jo Won Jung
Clin Exp Pediatr. 2004;47(4):424-429.   Published online April 15, 2004
Purpose : To evaluate the predictable factors for why initial intravenous immune globulin(IVIG) therapy failed and the outcome of coronary lesions after additional IVIG retreated in initial IVIG- resistant Kawasaki disease(KD). Methods : Retrospective studies were performed on 284 cases of KD treated with one episode of high-dose IVIG and 63 cases with additional IVIG retreatment at this hospital from January...
Assessment of Bronchial Hyperresponsiveness Using Chest Auscultation and Oxygen Saturation Measurement in Pre-school Children with a History of Wheezing
Young Yoo, Jinho Yu, Hee Kang, Eun Kyeong Kang, Young Yull Koh
Clin Exp Pediatr. 2004;47(4):417-423.   Published online April 15, 2004
Purpose : This study aimed to determine the efficacy and usefulness of chest auscultation and oxygen saturation measurement in the assessment of bronchial hyperresponsiveness to inhaled methacholine in pre-school wheezing children. Methods : One hundred and four children with histories of wheezing underwent bronchial challenges with nebulized methacholine using chest auscultation and oxygen saturation measurement. The challenge was considered positive when...
Study on the Correlation between Clinical Classification according to Hemorrhagic Symptoms and Platelet Counts in Childhood Idiopathic Thrombocytopenic Purpura
Ho Il Bang, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2004;47(4):412-416.   Published online April 15, 2004
Purpose : Idiopathic thrombocytopenic purpura(ITP) is a relatively common hematologic disease in children. The optimal strategy for treating ITP during childhood is a matter of controversy. In general, platelet count has been the primary, if not the sole measure, on which treatment decisions have been made and outcomes determined. In this study, we tried to find out the correlation between...
A Multivariate Analysis of Risk Factors of Renal Involvement in Henoch-Sch nlein Purpura
Min Jee Jeoung, Hyung Eun Yim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2004;47(4):405-411.   Published online April 15, 2004
Purpose : Long-term prognosis of Henoch-Sch nlein purpura(HSP) is determined by the existence and severity of renal involvement. We evaluated the relationship between various clinical features of HSP and the development of renal involvement using univariate and multivariate analyses for early detection and proper management of HSP nephritis. Methods : We performed a retrospective study of 200 children who were diagnosed...
Values of Lung CT in Children with a Vague History of Aspiration
Myoung-Bum Choi, Hyang-Ok Woo, Jum-Su Kim, Ji-Hyoun Seo, Jae-Young Lim, Chan-Hoo Park, Jin-Jong You, Hee-Shang Youn
Clin Exp Pediatr. 2004;47(4):399-404.   Published online April 15, 2004
Purpose : The purpose of this study was to investigate the diagnostic value of spiral computed tomography (CT) using contiguous slices with partially thin sections around the hilar level in the bronchial foreign bodies of children with a vague history of aspiration. Methods : Fourteen children were identified to be examined with spiral CT due to obscure histories of aspiration episodes....
Clinical and Virologic Study of Aseptic Meningitis
Hyun Ji Kim, Hae Kwan Cheong, Cheoll Jung, Kyu Man Lee, Young Mee Jee, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2004;47(4):392-398.   Published online April 15, 2004
Purpose : The cause of aseptic meningitis remains mostly unknown because viral culture and identification is difficult. Thus, we report a study on 123 children with aseptic meningitis in Gyeongju in 2002 to identify the causing virus and the relationship with the clinical manifestation. Methods : We prospectively investigated the patients, admitted to Dongguk University Hospital, into two groups between April...
Decreased Nonlinear Coupling of Peripheral Blood Volume to Heart Rate in Preterm Infants
Eun-Young Park, Chang-Ryul Kim, Myung-Kul Yum
Clin Exp Pediatr. 2004;47(4):386-391.   Published online April 15, 2004
Purpose : We investigated the autonomic nervous and complex modulation of heart rate and peripheral blood volume, and linear and nonlinear coupling between heart rate and peripheral blood volume in full-term and preterm infants. Methods : In twenty healthy preterm infants and twenty full-term infants at postconceptional age of 30-37 and 38-41 weeks each, we recorded electrocardiogram and photoplethysmogram simultaneously during...
Clinical Findings of Sepsis-Associated Cholestasis in the Neonates
Soo Jung Yoon, Chun Soo Kim, Sang Lak Lee
Clin Exp Pediatr. 2004;47(4):380-385.   Published online April 15, 2004
Purpose : Bacterial endotoxins or inflammatory cytokines are known to be important causes of cholestasis in patients with systemic infections such as sepsis. This study was undertaken to investigate the clinical features of cholestasis in newborn infants with sepsis. Methods : This study included 17 neonates with cholestasis diagnosed at the time of septicemia who had no previous history of cholestasis....
Clinical Characteristics and Epidemiologic Study of Infection Due to Extended Spectrum β-Lactamase Producing Organism in a Neonatal Intensive Care Unit
Nu-Lee Jun, Jae-Woo Im, Hyun-Kyung Park, Mi-Na Kim, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2004;47(4):373-379.   Published online April 15, 2004
Purpose : The extended-spectrum β-lactamase(ESBL) producing organism have emerged to be an important pathogen in neonatal intensive care unit(NICU). This study was conducted to investigate incidence, characteristics and risk factors associated with ESBL organism among newborns in NICU. Methods : The subjects included 98 newborns admitted to NICU at Asan Medical Center between September 1998 to July 2002, from whom...
The Effect of Parenteral Nutrition and Respiratory Distress Syndrome in the Early Neonatal Period on Bone Mineralization at the Time of Reaching 2 kg Body Weight in Premature Infants
Yun-Jin Lee, Su-Eun Park, Jae-Hong Park
Clin Exp Pediatr. 2004;47(4):368-372.   Published online April 15, 2004
Purpose : To evaluate the effect of parenteral nutrition in early neonatal period on bone mineralization at the time of reaching 2 kg body weight in premature infants, bone mineral density(BMD) in infants who received long-term parenteral nutrition in the early neonatal period was measured and compared with infants who received enteral nutrition only. Methods : Twenty low birth weight infants(those...
The Prevalence of Childhood and Adolescent Obesity in Jeju and Clinical Characteristics according to the Degree of Obesity
Jung Ho Seo
Clin Exp Pediatr. 2004;47(4):362-367.   Published online April 15, 2004
Purpose : Recently, childhood obesity has increased and became a major health concern in Korea. The aim of this study is to examine the prevalence of childhood and adolescent obesity in Jeju and to analyze clinical characteristics according to the degree of obesity. Methods : A total of 3,643 students from April 2002 to August 2002 were studied. To examine the...
Effects of Intestinal Ischemia on Intestinal Mucosal Damage and Effects of Interleukin-10 in Young Murine Model
Young-Shil Park, Dong-Chul Kim, Chung-Sik Chun
Clin Exp Pediatr. 2004;47(3):319-324.   Published online March 15, 2004
Purpose : Intestinal vascular ischemia is the most probable pathogenesis in the development of necrotizing enterocolitis in prematures. The authors studied the histology of intestinal mucosal damage by clamping the superior mesenteric artery in 35 rats, and, analyzed the histologic scores between young rats(I) and adult rats(II) groups according to clamping times(15, 30 and 60 minutes) and compared the effect...
The Effect of Growth Hormone on Patients with Growth Hormone Deficiency and Idiopathic Short Stature
Jeong Cheol Kang, Yoon Suk Choi, In Kyong Choi, Ho Sung Kim, Duk Hee Kim
Clin Exp Pediatr. 2004;47(3):310-318.   Published online March 15, 2004
Purpose : This study was designed to evaluate the effect of growth hormones on children with growth hormone deficiency(GHD) or idiopathic short stature(ISS). Methods : Between January 1988 to July 2003, 45 patients(M26, F19) with GHD and 24 patients (M13, F11) with ISS were enrolled in this study. Height standard deviation score(Ht SDS) for chronological age(CA) and Ht SDS for bone...
Characteristics of Pulmonary Atresia and Ventricular Septal Defect According to Morphologic Classification and Changes of Pulmonary Artery after Modified B-T Shunt
Kise Nam, Jeong Hoon Kim, Jae Young Choi, Jun Hee Sul, Sung Kue Lee, Young Hwan Park
Clin Exp Pediatr. 2004;47(3):304-309.   Published online March 15, 2004
Purpose : The purpose of this study is to help determine the optimal time and method for operation of pulmonary atresia(PA) with ventricular septal defect(VSD). Methods : Seventy patients who were diagnosed as PA with VSD in the Pediatric Department of Cardiology, Severance Hospital between May, 1991 and April, 1995, were included in our study. Subjects were divided into two groups...
Congenital Heart Disease in Jeju : Postnatal Incidence and Clinical Features
Jung Ha Lee, Gyu Hong Shim, Kyung Sue Shin, Jung Yun Hong, Yeoun Woo Kim, Seong Ho Kim, Chung Il Noh
Clin Exp Pediatr. 2004;47(3):294-303.   Published online March 15, 2004
Purpose : This is a retrospective descriptive study to determine the incidence of congenital heart disease(CHD) in Jeju and to estimate the suitability of the Jeju population as the subject for a regional birth cohort study. Methods : All patients with CHD diagnosed by two dimensional echocardiography in Cheju National University Hospital and Halla General Hospital from January 1999 to...
Utility of Abdominal Computerized Tomography in Diagnosis of Acute Appendicitis
Su Jin Sung, Ji Young Yeoun, Seong Hoon Lee
Clin Exp Pediatr. 2004;47(3):290-293.   Published online March 15, 2004
Purpose : To evaluate the accuracy of ultrasonography(USG) and abdominal computerized tomography(CT) and the possibility of reducing unnecessary appendectomy rate with improvement of diagnostic accuracy using optional CT with USG. Methods : From January 1999 to May 2003, 496 patients younger than 14 years received surgical intervention with preoperative impression of acute appendicitis. They were devided into three groups no...
Natural History of Chronic Hepatitis B in Children
Yuria Kim, Seoung Yeon Baek, Ji Hyun Eom, Ki Sup Chung
Clin Exp Pediatr. 2004;47(3):282-289.   Published online March 15, 2004
Purpose : We investigated the spontaneous seroconversion rate of hepatitis B viral markers and predictive factors affecting seroconversion in children with chronic hepatitis B. Methods : The study population included 214 children diagnosed as chronic hepatitis B, with positive HBsAg, HBeAg and HBVDNA over six months, and all patients had a family history of chronic Hepatitis B. They were followed between...
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