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Original Article
Clinical Significance of Gastrointestinal Symptoms and Abdominal Ultrasonographic Findings in Henoch-Schönlein Purpura
Eun Jung Choi, Chang Woo Lee, Du Young Choi
Clin Exp Pediatr. 2005;48(1):63-67.   Published online January 15, 2005
Purpose : Henoch-Sch nlein purpura(HSP) is a systemic vasculitis, characterized by cutaneous palpable purpura, gastrointestinal(GI) symptoms, arthritis and renal involvement. In general, the prognosis is determined by GI complication as well as the severity of nephritis. In this study, we analyzed the statistical relationship between the GI symptom and other clinical findings for assessing the prognosis, and evaluated abdominal ultrasonographic...
Comparison of Therapeutic Efficacy between Lamivudine and Alpha-Interferon in Korean Children with Chronic Hepatitis B at Two Years after the Initiation of Treatment
Byung-Ho Choe, You Cheol Jang, Chang Hwan Jang, Ki Won Oh, Jun Hwa Lee, Cheol Woo Ko
Clin Exp Pediatr. 2005;48(1):55-62.   Published online January 15, 2005
Purpose : We compared the therapeutic efficacy of lamivudine and alpha-interferon in children with chronic hepatitis B two years after the initiation of treatment, so that we could verify the safety and long term efficacy of lamivudine in children. Methods : We prospectively studied 44 children(32 male and 12 female; age, 1-18 years, mean, 9 years) treated for chronic hepatitis B...
Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2005;48(1):48-54.   Published online January 15, 2005
Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports...
Penicillin Resistant Distribution and in-vitro Susceptibility of Oral Antibiotics against Streptococcus pneumoniae, isolated from Pediatric Patients with Community- Acquired Respiratory Infections in Korea
Jin Han Kang, Sun Mi Kim, Jong Hyun Kim, Hur Jae Kyun, Kyung Yil Lee, Young Ku Shin, Su Eun Park, Sang Hyuk Ma, Young Jin Hong
Clin Exp Pediatr. 2005;48(1):40-47.   Published online January 15, 2005
Purpose : S. pneumoniae is one of major pathogens of community-acquired respiratory infections. The rate of antibiotic resistance to this organism has increased, and resistance to multiple antimicrobial agents in a single strain of S. pneumoniae may compromise the efficacy of empiric antimicrobial treatment commonly used for respiratory infections. We did this study to find out the penicillin resistant distributions...
The Clinical Study on the Neonate Delivered Under the Condition of the Maternal Smoking and Alcohol in Pregnancy
Sun Hui Kong, Soo Yeon Kim, Ho Jun Lee, Hak Sung Kim, Dong Woo Lee, Jae Yoon Kim
Clin Exp Pediatr. 2005;48(1):34-39.   Published online January 15, 2005
Purpose : Perinatal complications associated with maternal smoking and alcohol ingestion in pregnancy have been well documented. But until now there has been no clinical data on it collected in our country. In this paper, we tried to research the association between maternal smoking and alcohol ingestion in pregnancy and the physical indices of the neonate at delivery among unmaried...
Intrauterine Intraventricular Hemorrhage in Premature Infants
Hyun-Seung Jin, Kyeng-Ah Park, Hyun-Woo Goo, Jong-Hyun Yoon, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2005;48(1):27-33.   Published online January 15, 2005
Purpose : To determine incidence, characteristics and risk factors associated with intrauterine intraventricular hemorrhage(IU-IVH) among premature infants. Methods : The medical records of infants with intraventricular hemorrhage(IVH) admitted to the neonatal intensive care unit of Asan Medical Center from January 1999 to June 2003 were reviewed retrospectively. Infants whose IVH with cystic change were detected within five days of life were...
The Prevalence of Obesity, Serum Lipid Levels and Age at Menarche in Adolescent Female Athletes
Bo Young Kang, Yang Kyong Kim, Young Jin Hong, Byong Kwan Son, Kyung Ja Chang, Soon Ki Kim
Clin Exp Pediatr. 2005;48(1):21-26.   Published online January 15, 2005
Purpose : The aim of this study is to find the prevalence of obesity, the serum lipid levels and the age at menarche in adolescent female athletes and to examine the effects of exercise in adolescent stage. Methods : With a questionnaire regarding their age at menarche, physical measurement, body fat, and blood samples of the serum lipid levels to...
Prevalence of the Nonalcoholic Fatty Liver Disease in Obese Children
Sung Woog Hwang, Duk Hee Kim, Ho Seong Kim
Clin Exp Pediatr. 2005;48(1):13-20.   Published online January 15, 2005
Purpose : Obesity is, along with metabolic syndrome, closely related with nonalcoholic fatty liver disease. This study tried to evaluate the prevalence of nonalcoholic liver disease in obese children and verify the factors associated with the disease. Methods : Two hundred and seventy nine children who showed a body mass index of 95 percentile over the baseline in health examinations...
The Effects of Intravenous Immunoglobulin(IVIG) and Methylprednisolone on the mRNAs Expressions of VEGF, VCAM-1 and IL-1β of Human Umbilical Vein Endothelial Cells(HUVEC) Stimulated by IL-1β
Soh Yeon Kim, Sun Jeong Lim, Ji Whan Han, Kyung Yil Lee, Joon Sung Lee
Clin Exp Pediatr. 2004;47(12):1325-1333.   Published online December 15, 2004
Purpose : Kawasaki disease(KD) manifests a systemic vasculitis of unknown etiology in young children. Vascular endothelial growth factor(VEGF), vascular cell adhesion molecule-1(VCAM-1) and interleukin-1 beta(IL-1β) may play important roles in the pathogenesis of KD. Intravenous immunoglobulin(IVIG) and methylprednisolone(MP) are therapeutically effective for KD, however, the precise mechanisms of the two drugs are still unknown. We investigated the therapeutic efficacy of...
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
Clin Exp Pediatr. 2004;47(12):1319-1324.   Published online December 15, 2004
Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel...
A Clinical Study on the Etiologies of Acute Seizures in Children Who Visited Emergency Department
Jung Il Cho, Dong Wook Kim, Hyun Oh Jang, Jin Soo Moon, Seung Yeon Nam, Seung Yeon Nam
Clin Exp Pediatr. 2004;47(12):1312-1318.   Published online December 15, 2004
Purpose : Although it is important to know the etiologies of childhood seizures according to age, clinical studies on this topic have been few. The present study was therefore designed to investigate the causes of acute childhood seizures. We hope this study will be helpful in the diagnosis and management of children with seizures. Methods : This study was retrospectively undertaken...
A Clinical Study on Benign Convulsions with Mild Gastroenteritis
Jung Il Cho, Dong Wook Kim, Hyun Oh Jang, Jin Soo Moon, Seung Yeon Nam, Chong Guk Lee
Clin Exp Pediatr. 2004;47(12):1306-1311.   Published online December 15, 2004
Purpose : 'Benign convulsions with mild gastroenteritis(BCwMG)' is afebrile seizures associated with gastroenteritis without dehydration or electrolyte imbalance in young children aged almost 6 months to 3 years. Because seizures can occur repeatedly, patients can be misdiagnosed with epilepsy. Therefore, understanding the characteristics of this disease is thought to be important. This study was carried out to investigate the clinical...
Prevalence of Antibodies against Adenoviruses in Korean Children and Adults
Hyun Oh Jang, Jin A Lee, Nam Hee Kim, Eun Hee Chung, Hoan Jong Lee
Clin Exp Pediatr. 2004;47(12):1300-1305.   Published online December 15, 2004
Purpose : Adenoviruses(Ads) are responsible for approximately 10 percent of lower respiratory tract infections(LRTIs) in children. The purpose of this study is to evaluate the prevalence of antibodies (Abs) against common serotypes of Ads in Korean children and adults. Methods : The sera were tested for neutralizing Abs against Ad serotypes 1 through 7 and 21 with a colorimetric microneutralization assay...
Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant
Ki Dae Kim, Byeong Hee Son, Chang Whan Oh, Jung A Lee, Sung Won Kim
Clin Exp Pediatr. 2004;47(12):1293-1299.   Published online December 15, 2004
Purpose : This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants. Methods : Interleukin-1β(IL-1β), Interleukin-6(IL-6), Tumor necrosis factor-α(TNF-α) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records. Results...
Usefulness of the Transcutaneous Bilirubinometer in Neonatal Jaundice
Joo Ran An, Sung Won Park, Hee Chul Lee, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2004;47(12):1287-1292.   Published online December 15, 2004
Purpose : To test the usefulness of a new jaundice meter, the JM-103(Minolta/Hill-Rom Air-shields, Japan) which uses a new probe to compensate for different skin pigmentation or thickness, and displayed actual bilirubin level instead of an index number as in the previous model, the JM-102, we compared transcutaneous bilirubin(TCB) with plasma bilirubin(PB) in newborn infants. Methods : TCB was measured on...
Usefulness of Intraoperative Transesophageal Echocardiography
Dong Won Lee, Byung Mok Kim, Sei Young Kim, Yeo Hyang Kim, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2004;47(12):1281-1286.   Published online December 15, 2004
Purpose : This study was undertaken to learn the usefulness, cost-effectiveness and safety of intraoperative transesophageal echocardiography(ITEE) during open heart surgery for congenital heart diseases. Methods : The usefulness and safety of ITEE were assessed in 254 patients who underwent open heart surgery for congenital heart diseases from January 1, 2001 to June 30, 2003, with retrospective chart reviews and a...
Serum Lipids of School Children and Adolescence in Urban and Rural Area
Dong Han Shin, Hee Sun Lee, Kee Hyoung Lee, Baik-Lin Eun, Chae Seung Lim, Young Chang Tockgo
Clin Exp Pediatr. 2004;47(12):1273-1280.   Published online December 15, 2004
Purposes : A cross-sectional study on serum lipids in school children and adolescents was carried out in two different areas in 2002. We studied to determine of the difference in lipids level of children between urban and rural areas and changes of cholesterol levels compared to those of early- 1990 studies. Methods : A cross-sectional study on serum lipids in school...
Applicability of the "Questionnaire on Risk Factors Associated with Obesity in Adolescents" in School-Based Screening to Prevent Life Style Disease as a Result of Complicated Adolescent Obesity
Yoon Hee Shim, Ji Young Kim, Soo Jeung Lee, Su Jin Cho, Whaan Kuck Yeong, Young Mi Hong
Clin Exp Pediatr. 2004;47(12):1266-1272.   Published online December 15, 2004

Purpose: The prevalence of obesity and complications related to obesity among Korean adolescents were reviewed. To prevent obesity related complications in adolescents, the applicability of the "Questionnaire on risk factors associated with obesity in adolescents" as an assessment and management guideline was evaluated. Methods: Weight, height, blood pressure and serum lipid and glucose level of 7,265 high school students in Seoul...
Possible Neuroprotective Role of Exogenous Growth Hormone on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Young Pyo Chang, Mi Kyung Jung, Youn Hee Jee, Jae Ju Cho, Soon Bum Lee, Woo Sung Park, Jong-Wan Kim, Dong Hoon Shin
Clin Exp Pediatr. 2004;47(11):1210-1215.   Published online November 15, 2004
Purpose : This study was performed to evaluate the possible neuroprotective effect of exogenous growth hormone on hypoxic-ischemic brain injury in neonatal rats. Methods : After ligation of the right common carotid artery, seven-day old Sprague-Dawley rats(n= 75) were exposed to 8% oxygen for two hours. In a growth hormone(GH)-treated group(n=25), each animal was subcutanously injected by GH(50 mg/kg, Grotrpin ,...
Urine Organic Acid Analysis of Patients with Febrile Seizures
Dong Soo Shin, Gun Jun Lee, Kyeung Ja Lee, Won Il Park, Eun Joo Bae, Hong Gin Lee
Clin Exp Pediatr. 2004;47(11):1205-1209.   Published online November 15, 2004
Purpose : Febrile seizure, the most common seizure disorder in children between 6 months and 5 years of age, is mostly caused by viral infections, except severe CNS infection. It can also be caused by disorders in organic acid metabolism, especially accompanied by fever. Therefore we decided to investigate the relationship between children with febrile seizures and disorders in organic...
The Incidence and Risk Factors of Posttraumatic Seizure in Children
Sue Youn, Mi A Lee, Hwang Min Kim, Byung Ho Cha
Clin Exp Pediatr. 2004;47(11):1198-1204.   Published online November 15, 2004
Purpose : The goal of our study was to identify the incidence and clinical, neurophysiological and neuroradiological variables with predictive value for posttraumatic seizure(PTS). Methods : The medical records of 625 children with head traumas under 15-year-old who were admitted to the Wonju Christian Hospital, from January, 1993 to January, 2002 were retrospectively reviewed. Among them, 472 patients were included...
Detection of Cytokeratin-19 caused by Intestinal Epithelial Cell Damage in Childhood Diarrhea
Ja Young Hwang, Se Young Seo, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Won-Bae Lee
Clin Exp Pediatr. 2004;47(11):1193-1197.   Published online November 15, 2004
Purpose : Acute gastroenteritis in infancy is a very common disease with a frequency of a billion diarrhea per year, leading to 3 to 5 million deaths. Since the etiology is not always clear, the treatment plan can be quite difficult to make. The laboratory examinations of stool culture, along with complete blood counts may sometimes be helpful to find...
A Clinical Study of Chronic Functional Constipation in Children Treated for more than Five Months
Young Min Kim, Sung Yun Choi, Sun Hwan Bae, Young Min Ahn
Clin Exp Pediatr. 2004;47(11):1186-1192.   Published online November 15, 2004
Purpose : The purpose of this study was to evaluate the clinical features and the courses and effects of long-term treatment, and to analyze the association between clinical features and duration of therapy in chronic functional constipation in children. Methods : This study enrolled 57 children with chronic functional constipation who were treated in the Eulji Hospital for more than...
Epidemiologic Study of Aseptic Meningitis in Daejeon, Korea(1987 through 2003)
Jung-Hoon You, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Chul Lee
Clin Exp Pediatr. 2004;47(11):1181-1185.   Published online November 15, 2004
Purpose : To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003. Methods : A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed. Results : The mean annual number of cases was 129, with a higher rate of occurrence in the...
Functional Antibody Responses to Seven Serotypes in Pneumococcal Polysaccharide Vaccine in Children
Ji Hye Park, Hee Jung Kim, Young Mi Hong, Kyung Hyo Kim
Clin Exp Pediatr. 2004;47(11):1173-1180.   Published online November 15, 2004
Purpose : Streptococcus pneumoniae is an important pathogen in children as well as in elderly people. The aim of this study was to assess the opsonization activity of pneumococal capsular antibody to seven serotypes in 23-valent pneumococcal polysaccharide vaccine before and after immunization in Korean children. Methods : Nine children from 24 to 49 months of age were immunized with 23-valent...
High Frequency Oscillatory Ventilation with Inhaled Nitric Oxide Combined Therapy in The Intractable Respiratory Failure Neonates
Mi Hyun Lee, Ji Eun Han, Sang Geel Lee
Clin Exp Pediatr. 2004;47(11):1167-1172.   Published online November 15, 2004
Purpose : Inhaled nitric oxide(iNO) has been known to improve oxgenation in newborns with persistent pulmonary hypertension(PPHN), but it's not clear that iNo treatment is effective in cases of acute, hypoxic respiratory failure and premature infants. In our study, high frequency oscillatory ventilation(HFV) with iNO combined therapy was tried in intractable respiratory failure neonates who showed no response to conventional...
Clinical Features of Septic Arthritis in Neonates
Min Jung Kwak, Su Eun Park
Clin Exp Pediatr. 2004;47(11):1161-1166.   Published online November 15, 2004
Purpose : Septic arthritis is uncommon in neonates, and the diagnosis of septic arthritis in newborns is difficult because of non-specific laboratory findings and paucity of signs and symptoms. When appropriate treatment is delayed, permanant sequelae are inevitable. We report a retrospective study of 22 neonates who were diagnosed with septic arthritis. Methods : We reviewed 22 patients, who were diagnosed...
Review of Chromosomal Analyses Performed in a Single Hospital
Hong Kug Kim, Nam Hyang Koo, Jin Soon Hwang, Sung Hwan Kim
Clin Exp Pediatr. 2004;47(11):1157-1160.   Published online November 15, 2004
Purpose : Chromosomal aberration has an effect on the lives of both patients and families. Peripheral blood chromosomal analysis is useful to make a diagnosis and counsel the patient with chromosomal abnormality. We studied the cases with peripheral blood chromosomal analyses and investigated the positivity of peripheral blood chromosomal analysis. Methods : We analyzed 650 patients with chromosomal analyses in Ajou...
Prevalence of Metabolic Syndrome in Obese Children
Jin Ha Chang, Duk Hee Kim, Ho-Seong Kim, In Kyoung Choi, My Young Cheong, Dong Kee Kim
Clin Exp Pediatr. 2004;47(11):1149-1156.   Published online November 15, 2004
Purpose : Obesity has been known to be a cause of insulin resistance and dyslipidemia, and along with coronary artery disease and diabetes, is associated with metabolic syndrome(MS). This study aimed to ascertain the cause and prevalence of MS in obese children and adolescents. Methods : Two hundred and seventy-seven school children, who showed more than a 95th percentile of body...
Thermogenic Response to Fasting and Exercise in Different Aged Rats
Ae Jung Kwak, Kwang Hae Choi, Yong Hun Park, Yong Woon Kim
Clin Exp Pediatr. 2004;47(10):1100-1105.   Published online October 15, 2004
Purpose : Recently, there has been a marked increase in childhood obesity, and that has aroused social concern. Obesity increases several metabolic disease such as hypertension, diabetes, fatty liver, heart disease and the mortality rate. Complications of obesity are more closely related with the accumulation of visceral fat. Therefore, fundamental treatment of obesity Should be the reduction of body fat....
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