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Clinical Findings of Mycoplasma Pneumonia in Children, from 1998 to 2003
Ji-Hyun Kim, Soo Ahn Chae, Dong-Keun Lee
Clin Exp Pediatr. 2005;48(9):969-975.   Published online September 15, 2005
Department of Pediatrics, College of Medicine, Chung Ang University, Seoul, Korea Purpose : We performed a study of clinical findings of Mycoplasma Pneumonia in children, to know differences between recent clinical manifestations of Mycoplasma pneumonia and previous studies. Methods : The subjects of this study were 393 children who were diagnosed as Mycoplasma pneumonia with high titers of Mycoplasma antibody(≥1 : 160)...
The Safety and Immunogenicity of a Trivalent, Live, Attenuated MMR Vaccine, PriorixTM
Seung-In Ahn, Min-Kook Chung, Jung-Suk Yoo, Hye-Jeon Chung, Jae-Kyun Hur, Young-Kyu Shin, Jin-Keun Chang, Sung-Ho Cha
Clin Exp Pediatr. 2005;48(9):960-968.   Published online September 15, 2005
Purpose : This multi-center, open-label, clinical study was designed to evaluate the safety and immunogenicity of a trivalent, live, attenuated measles-mumps-rubella(MMR) vaccine, PriorixTM in Korean children. Methods : From July 2002 to February 2003, a total of 252 children, aged 12-15 months or 4-6 years, received PriorixTM at four centers : Han-il General Hospital, Kyunghee University Hospital, St. Paul's Hospital at...
Clinical Use and Complications of Percutaneous Central Venous Catheterization in Very Low Birth Weight Infants
Hyang Kim, Sun Hui Kim, Hyung Suck Byun, Young Youn Choi
Clin Exp Pediatr. 2005;48(9):953-959.   Published online September 15, 2005
Purpose : The administration of total parenteral nutrition(TPN) has become a standard procedure in the management of nutritionally deprived and critically low birth weight neonates. Sepsis remains the most frequent serious complication during TPN, resulting in increased morbidity, mortality and health care costs. This study was performed to evaluate the clinical efficacy and complications of percutaneous central venous catheterization(PCVC) in...
Prevalence and Risk Factors of Vancomycin-Resistant Enterococci (VRE) Colonization in Neonates
Hwa Yun Lee, Gi Hwan Kim, Jin Su Choi, Sun Hee Kim, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 2005;48(9):946-952.   Published online September 15, 2005
Purpose : Vancomycin-resistant enterococci(VRE) are now nosocomial pathogens in Korea. But little is known about the prevalence of stool colonization with VRE in neonates in Korea. So we studied the prevalence and risk factors of VRE colonization in the Neonatal Intensive Care Unit(NICU). Methods : From January 2000 to December 2004, the medical records of 294 neonates(127 cases of VRE group...
Outcomes and Management of Fetal Infants with Birth Weight Below 500 g at a Tertiary Center
Yun Sil Chang, Yu Jin Kim, Soo Hyun Koo, Jang Hoon Lee, Jong Hee Hwang, Chang Won Choi, Jae Won Shim, Sung Shin Kim, Sun Young Ko, Eun Kyung Lee, Won Soon Park
Clin Exp Pediatr. 2005;48(9):939-945.   Published online September 15, 2005
Purpose : The purpose of this study was to report outcome of fetal infants with birth weight below 500 g known as lower limit of viability and to evaluate treatment characteristics and short-term morbidity of their survivors. Methods : We retrospectively analyzed the medical records of all fetal infants with birth weight below 500 g who were delivered at Samsung Medical...
Carotid Intima-Media Thickness Measurement in Obese Children
Kyung Ok Park, Suk Ju Choi, Hee Hyun Yeom, Sochung Chung, Jeong Jin Yu, Youngshin Park, Dong Hwan Lee
Clin Exp Pediatr. 2005;48(9):935-938.   Published online September 15, 2005
Purpose : The aim of the present study was to ascertain whether the increase of carotid intima- media thickeness(cIMT) as one of premature pathologic changes of atherosclerosis, was present in obese children compared to normal weight children. Methods : The obese group consisted of 21 obese/overweight(body mass index(BMI) above 85 percentile of age, sex standards) children and the control group of...
Complementary and Alternative Medical Therapies in Children and Adolescent with Chronic Disease : Utilizations and Patterns
Young Bin Kim, Jun Ho Song, Myoung Wan Jang, Hwang Jae Yoo, Cheol Hong Kim, Hyun Hee Lee
Clin Exp Pediatr. 2005;48(9):929-934.   Published online September 15, 2005
Purpose : This study describes how often complementary and alternative medical(CAM) therapies, what patterns of CAM therapies utilization, what types of CAM therapies and why CAM therapies are used in children and adolescent with chronic disease. Methods : We interviewed and filled out questionnaires with parents of patients suffering from asthma, atopic dermatitis, congenital myopathy, epilepsy and so on from Mar...
The Efficacy of Speech and Language Therapy for Children with Speech and Language Delays according to the Eiologies
June-Bum Kim, Jin-Soon Suh, Young-Hoon Kim, Seung-Yun Chung, In-Goo Lee, Kyung-Tai Whang, Byung-Churl Lee
Clin Exp Pediatr. 2005;48(9):924-928.   Published online September 15, 2005
Purpose : Treatment efficacy for children with speech and language delay has been the subject of considerable debate in recent years. We evaluated the clinical features of children with delayed speech and language and their prognoses according to their etiologies after 6 months of speech and language therapy. Methods : From January, 2000 to March, 2004, we retrospectively reviewed 56...
Ex vivo Expansion and Clonal Maintenance of CD34＋ Selected Cells from Cord Blood and Peripheral Blood
Soon Ki Kim, Hye Yoon Ghil, Sun U. Song, Jong Weon Choi, Sang Kyu Park
Clin Exp Pediatr. 2005;48(8):894-900.   Published online August 15, 2005
Purpose : Because of the unavailability of marrow transplantation, umbilical cord blood (CB) is increasingly being used. We evaluated the potential of ex vivo expansion and clonality in CD34＋ cells separated from cord blood source and mobilized peripheral blood (PB) in a serum-free media. Methods : The CD34＋ cells, selected from CB and mobilized PB, were expanded with hematopoietic growth...
Inhibition of Vascular Endothelial Growth Factor-induced Endothelial Cell Differentiation by Intravenous Immunoglobulin and Methylprednisolone
Hyoun Ah Choi, Kyung Hwa Ha, Jong Seo Yoon, Yoon Lee, Joon Sung Lee, Ji Whan Han
Clin Exp Pediatr. 2005;48(8):886-893.   Published online August 15, 2005
Purpose : Kawasaki disease is the most common cause of systemic vasculitis in children less than 5 years of age. Recent immunohistochemistry findings suggest that many vascular growth factors play a role in the formation of the coronary artery lesions. Active remodeling of the coronary artery lesions in Kawasaki disease continues in the form of intimal proliferation and neoangiogenesis for...
Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
Clin Exp Pediatr. 2005;48(8):881-885.   Published online August 15, 2005
Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide...
Clinical Findings of Genotypes in Korean Patients with Glycogen Storage Disease Type Ia
Jae Sung Ko, Hye Ran Yang, Jong Won Kim, Jeong Kee Seo
Clin Exp Pediatr. 2005;48(8):877-880.   Published online August 15, 2005
Purpose : Glycogen storage disease type Ia(GSD Ia) is an autosomal recessive disorder caused by the deficiency of glucose-6-phosphatase(G6Pase). The aim of the study was to investigate the spectrum of G6Pase gene mutations and relationship between genotype and clinical findings in Korean patients with GSD Ia. Methods : Genomic DNA was extracted from peripheral leukocytes of 20 patients with GSD...
Tumor Necrosis Factor and Lymphotoxin-α Gene Polymorphism in Korean Children with Type 1 Diabetes
Jin Soon Suh, So Young Park, Min Ho Jung, Byung Kyu Suh, Tae Gyu Kim, Byung Churl Lee
Clin Exp Pediatr. 2005;48(8):871-876.   Published online August 15, 2005
Purpose : Recently, it was reported that tumor necrosis factor(TNF) and lymphotoxin-α(LT-α) gene regions might be a susceptible loci to type 1 diabetes in Japanese. The purpose of this study was to investigate the association of TNF and LT-α gene polymorphisms with disease susceptibility in Korean children with type 1 diabetes. Methods : Forty-nine Korean children with type 1 diabetes(29...
Effects of Growth Hormone Therapy in Children with Idiopathic Short Stature
Kyong A Lee, Heon Seok Han
Clin Exp Pediatr. 2005;48(8):865-870.   Published online August 15, 2005
Purpose : The use of growth hormone(GH) to promote growth in normal short children without classical GH deficiency is controversial. Numerous foreign studies have shown the effects of GH therapy in children with idiopathic short stature(ISS) whereas few has been interested in Korea. Therefore, this study is designed to investigate the effects of GH therapy on ISS by observing correlations...
Relationship between the Body Fat Mass Measured by Bioelectrical Impedance Analysis(BIA) and Dual Energy X-ray Absorptiometry(DEXA), and by the Indices of Insulin Sensitivity
In Seok Lim, Ki Wook Yun
Clin Exp Pediatr. 2005;48(8):857-864.   Published online August 15, 2005
Purpose : The objectives of this study was to evaluate the correlations between the indices of insulin sensitivity using fasting glucose and insulin level, and the body fat mass measured by bioelectrical impedance analysis(BIA) and dual energy X-ray absorptiometry(DEXA), and to determine the clinical usefulness of insulin sensitivity indices when obese children were followed up. Methods : In this study, 28...
Quantitative Assessment of Myocardial Tissue Velocity in Normal Children with Doppler Tissue Imaging : Reference Values, Growth and Heart Rate Related Change
Se Young Kim, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2005;48(8):846-856.   Published online August 15, 2005
Purpose : To measure the peak myocardial tissue velocities and patterns of longitudinal motion of atrioventricular(AV) annuli and assess body weight and heart rates-related changes in normal children. Methods : Using pulsed wave Tissue Doppler Imaging(TDI), we measurpeak systolic, early and late diastolic myocardial velocities in 72 normal children at six different sites in apical-4 chamber (A4C) view and at...
Clinical Evaluation of Tissue Biopsy for Children with Neck Mass; A Single Center Study
You Sook Youn, Hye Won Yoon, Sun Young Kim, Ji Young Sul, Chang Jun Song, Jin Man Kim, Kyung Duk Park
Clin Exp Pediatr. 2005;48(8):839-845.   Published online August 15, 2005
Purpose : Neck masses, in pediatric population, derive from a multitude of congenital, inflammatory, or neoplastic diseases. The majority of these masses represent benign conditions. However, thorough clinical evaluation is required to rule out malignant diseases. We evaluated the causes, clinical characteristics and outcomes of children with neck masses who underwent tissue biopsy. Methods : A total of 28 medical records...
Hepatitis Complicated with Mycoplasma pneumoniae Infection in Children
Seung Min Lee, Sung Moon Lee, Hann Tchah, In Sang Jeon, Eell Ryoo, Kang Ho Cho, Yong Han Seon, Dong Woo Son, Hee Joo Hong
Clin Exp Pediatr. 2005;48(8):832-838.   Published online August 15, 2005
Purpose : Mycoplasma pneumoniae infection is relatively common in childhood. Its extrapulmonary manifestations have been reported so much, but hepatitis associated with it has been reported rarely in Korea. Methods : A clinical study was performed on 556 patients of M. pneumoniae pneumonia diagnosed serologically at Gil hospital from January 2001 to December 2004. We reviewed 65 cases among these patients,...
The Developmental Outcome of Fetal Mild Isolated Ventriculomegaly
Myung Sook Jeong, Jung Mi Chun, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin, Eu Ree Lee
Clin Exp Pediatr. 2005;48(8):826-831.   Published online August 15, 2005
Purpose : This study is directed to evaluate standardized developmental test performances of infants and children who, as fetuses, had mild isolated cerebral ventriculomegaly diagnosed by ultrasound. Methods : All prenatal sonographic findings from 2001 to 2002 were evaluated. Live isolated mild ventriculomegaly(IMVM) of 10-15 mm were observed in 95 cases(1.1 percent). Standardized developmental testing of 40 cases of IMVM and...
A Study for Accuracy and Usefulness of Tympanic Membrane and Forehead Thermometers
Ki Wook Yun, In Seok Lim
Clin Exp Pediatr. 2005;48(8):820-825.   Published online August 15, 2005
Purpose : The presence and degree of fever in children is a useful indicator of illness. This project aimed to assess the accuracy and usefulness of infrared tympanic membrane(TM) & forehead feverscan thermometers for measuring children's temperatures. Methods : Data were obtained from 1,050 children with a median age of 4.5 years. They visited the pediatric clinics at Chung-Ang University Yongsan...
Medicolegal Problems in Pediatric Area
Soo Jeong Kwon, Ji Young Jang, Nam Su Kim, Myung Kul Yum, In Joon Seol, Ku Won Jung
Clin Exp Pediatr. 2005;48(8):813-819.   Published online August 15, 2005
Purpose : Medicolegal problems start when the patient asserts the mistake of doctor and doctor does not accept it. The purpose of this study is to assess the actual condition of medicolegal problems and to provide solutions of medicolegal problems in the pediatric field. Methods : There is not official statistical data about medicolegal problems in our country. We gathered...
The Effects of Echinacea Extract on the Gene Expression of Monocytes and Monocyte-derived Dendritic Cells
Jun Eun Park, Kang Duk Choi, Sung Hwan Kim, Dae-Hyun Hahm, Jong Jin Seo
Clin Exp Pediatr. 2005;48(7):779-788.   Published online July 15, 2005
Purpose : Echinacea, a traditional plant medicine has been used as immune-stimulant. Recent studies have revealed that extract of Echinacea has immunostimulatory effects on human blood mononuclear cells. This study was designed for the purpose of screening the genes associated with immunologic effects of Echinacea on monocytes and dendritic cells using a cDNA microarray chip. Methods : CD14＋ monocyte cells...
Serum Nitric Oxide and Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease
Ji Hye Park, Jee Seon Shin, Young Mi Hong
Clin Exp Pediatr. 2005;48(7):772-778.   Published online July 15, 2005
Purpose : Kawasaki disease(KD) is a systemic panvasculitis that causes coronary artery lesions. KD is accompanied by immunoregulatory abnormalities. Nitric oxide(NO) can induce relaxation of blood vessels by activating guanylate cyclase in smooth muscle cells and high levels of NO may result in coronary artery lesions. We investigated tumor necrosis factor(TNF)-α and NO production before and after intravenous immunoglobulin(IVIG) therapy...
Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma
Kyung-Sue Shin, Youn Woo Kim
Clin Exp Pediatr. 2005;48(7):766-771.   Published online July 15, 2005
목 적 : 류코트리엔 수용체 길항제는 천식의 병리 반응에 관여하는 cysteiny leukotriene의 생성과 작용을 억제하여 급성기 천식 증상의 치료와 천식 증상의 조절 요법에 사용할 수 있다. 본 연구에서는 소아 천식환자에서 cysteinyl leukotriene 생성에 관여하는 LTC4S 유전자 다형태와 류코트리엔 수용체 길항제인 montelukast의 임상적 효과를 조사하여 약물유전학적 연관성 유무를 알고자 하였다. 방 법 : 환자군은 경증 지속성 천식과 중등증 지속성 천식환자 161명을 대상으로...
Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children
Yung Kwun Lee, Hee Chul Lee, Jung Mi Chun, So Young Yoon, Woo Gill Lee, Son Moon Shin
Clin Exp Pediatr. 2005;48(7):760-765.   Published online July 15, 2005
Purpose : We studied the changes in antibiotic sensitivity to the causative organisms of urinary tract infection(UTI), in order to provide useful information on the choice of adequate drugs in the treatment of UTI. Methods : We retrospectively analyzed the major causative organisms and their antibiotic sensitivities in 69 patients diagnosed with UTI in the Department of Pediatrics, Samsung Cheil Hospital...
Clinical Features of Benign Infantile Convulsions with Gastroenteritis
Jung Sun Lee, Hae Oak Kwon, Young Mee Jee, Kyu Young Chae
Clin Exp Pediatr. 2005;48(7):753-759.   Published online July 15, 2005
Purpose : This study was performed to characterize clinical features of benign convulsions with gastroenteritis(CwG) in infants. Methods : We reviewed clinical features of 67 episodes in 64 patients with afebrile seizure accompanied gastroenteritis admitted to Dept. of Pediatrics Bundang CHA hospital from January 2001 to June 2004. Patients with meningitis, encephalitis/encephalopathy or apparent history of epilepsy were excluded. Results : There...
Measurement of the Common Carotid Artery by Ultrasound as a Predictor of Atherosclerosis in Obese Adolescents
Ye Jin Kim, Yoon Hee Shim, Joung Hyun Yoo, Keun Lee, Young Mi Hong
Clin Exp Pediatr. 2005;48(7):745-752.   Published online July 15, 2005
Purpose : Adolescent obesity is known to be associated with complications such as hypertension, coronary artery disease and insulin resistance. We measured the common carotid artery by ultrasound as a predictor of atherosclerosis, and investigated the relationship between carotid artery parameters and serum cytokines in obese adolescents. Methods : Twenty-nine obese adolescents(16-17 years old, obesity index>130 percent) and twenty- seven...
Airway Compression or Airway Anomaly Causing Respiratory Symptoms in Infants and Children with Cardiovascular Diseases
Ja-Hyeong Kim, So-Yeon Lee, Hyo-Bin Kim, So-Eun Koo, Sung-Jong Park, Young-Hui Kim, In-Suk Park, Jae-Kon Ko, Dong-Man Seo, Soo-Jong Hong
Clin Exp Pediatr. 2005;48(7):737-744.   Published online July 15, 2005
Purpose : Infants and children with cardiovascular diseases often present with respiratory symptoms. However, missed or delayed evaluation for potential airway problem may complicate overall prognosis. The aim of this study is to determine the clinical characteristics of these patients and explore the cause of airway problem. Methods : We reviewed the medical records of 64 patients(M : F=33:31, mean...
Clinical Study of Acute Pyogenic Osteomyelitis in Children
Ji Sook Park, Jeong Suk Yeom, Sun Chul Hwang, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn
Clin Exp Pediatr. 2005;48(7):731-736.   Published online July 15, 2005
Purpose : Acute pyogenic osteomyelitis is uncommon in children. Delayed diagnosis and inappropriate treatment are leading to growth failure and deformation. We review the clinical manifestations and treatment of acute osteomyelitis in children according to age. Methods : A retrospective analysis was made of 32 patients who underwent antibiotic management or operation between Aug 1989 and Dec 2003 for acute...
Etiology and Clinical Features of Viral Lower-respiratory Tract Infections in Children in Winter, 2003
Byung Ho Yun, Hee Chul Lee, Jung Mi Chun, So Young Yoon, Woo Gill Lee, Son Moon Shin
Clin Exp Pediatr. 2005;48(7):723-730.   Published online July 15, 2005
Purpose : This study was performed to characterize the etiology and clinical features of acute viral lower-respiratory tract infections(LRI). Methods : Etiologic agents and clinical features of acute viral LRI were studied from October. 2003 through March. 2004 in hospitalized children with LRI(253 cases) at Samsung Cheil Hospital. The viruses were identified by indirect immunofluorescent method. Medical records of patients with...
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