Korean Journal of Pediatrics 2005;48(7):760-765.
Published online July 15, 2005.
Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children
Yung Kwun Lee, Hee Chul Lee, Jung Mi Chun, So Young Yoon, Woo Gill Lee, Son Moon Shin
Department of Pediatrics, Samsung Cheil Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
소아 요로감염증의 주요 원인균과 항생제 감수성
이용권, 이희철, 천정미, 윤소영, 이우길, 신손문
성균관대학교 의과대학 삼성제일병원 소아과
Correspondence: 
So Young Yoon, Email: liobaped@hanmail.net
Abstract
Purpose
: We studied the changes in antibiotic sensitivity to the causative organisms of urinary tract infection(UTI), in order to provide useful information on the choice of adequate drugs in the treatment of UTI.
Methods
: We retrospectively analyzed the major causative organisms and their antibiotic sensitivities in 69 patients diagnosed with UTI in the Department of Pediatrics, Samsung Cheil Hospital from 2002 to 2003.
Results
: The frequency of UTI was the highest in infants younger than 1 year of age(88.4 percent). The male to female ratio was 3.05 : 1. Escherichia coli was the most frequent organism(78.3 percent), followed by Klebsiella(11.6 percent), Pseudomonas(2.9 percent), Proteus(2.9 percent), Enterobacter, Morganelle, and Enterococcus(1.4 percent) in descending order. Antibiotic sensitivity of gram negative organisms was above 90 percent against imipenem, amikacin, 80 percent against aztreonam, cefepime, ceftriaxone, 50-70 percent against gentamicin, trimethoprime-sulfamethoxazole (TMP/SMX), and 23 percent against ampicillin(23.4 percent).
Conclusion
: Antibiotict sensitivity of gram negative organisms was high to amikacin and third generation cephalosporins but low to ampicillin, gentamicin and TMP/SMX. The use of ampicillin or TMP/SMX, as the first choice of the empiric and prophylactic treatment for UTI, should be reconsidered and investigated further.
Key Words: Urinary tract infection , Urine culture , Escherichia coli , Antibiotic sensitivity


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