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Original Article
Evaluation of diagnostic methods in children with nonpalpable undescended testis
Noh Sung Seok, Hong Jin Suh, Dong Hwan Lee
Clin Exp Pediatr. 2006;49(7):732-736.   Published online July 15, 2006
Purpose : Numerous methods exist for diagnosing nonpalpable testis in treatment of cryptochidism. However, there is no clinically established data for the rational diagnostic tool of nonpalpable testis in terms of expenses. We tried to establish a current conventional diagnostic course of nonpalpable testis. We then evaluated the efficacy of ultrasonography, physical examination under general anesthesia and laparoscopy for diagnosing...
The efficacy of optimal doses of intramuscular ketamine and midazolam injections for procedural sedation in laceration repair of children
Je Sung You, Young Soon Cho, Young Hwan Choi, Seung Hwan Kim, Hahn Shick Lee, Jin Hee Lee
Clin Exp Pediatr. 2006;49(7):726-731.   Published online July 15, 2006
Purpose : We reported previously that intramuscular ketamine with adjunctive midazolam is more effective than ketamine alone in pediatric procedural sedation, but with limited satisfactory sedation by suboptimal ketamine dose. The optimal dose of intramuscular ketamine in children has never been studied in Korea. In this study, we investigated the effectiveness and adverse events of ketamine 4mg/kg with adjunctive midazolam...
Umbilical venous line-related pleural and pericardial effusion causing cardiac tamponade in a premature neonate : A case report
Eun Jeong Hong, Kyung A Lee, Il-Heon Bae, Mi-Jung Kim, Heon-Seok Han
Clin Exp Pediatr. 2006;49(6):686-690.   Published online June 15, 2006
Cardiac tamponade with pleural and pericardial effusion is a rare but life-threatening complication of umbilical venous catheterization in the newborn. It requires a timely diagnosis and urgent treatment, such as pericardiocentesis, to save lives of affected patients. Recently, we experienced a 7 day-old, very low birth weight infant, who developed a cardiac tamponade with pleural and pericardial effusions complicated by...
Effect of maternal thyroxine treatment on the offspring's brain development with fetal alcohol effects in the rats
Jin Fu, Yoon Young Chung, Sang Kee Park
Clin Exp Pediatr. 2006;49(6):677-685.   Published online June 15, 2006
Purpose : This study aimed to investigate whether exogenous thyroxine(T4) treatment to alcohol-fed dams would ameliorate the detrimental effects of alcohol on the postnatal development of neuropeptide-Y(NPY)-containing neurons of the cerebral cortex and hippocampus of the offspring. Methods : Time-pregnant rats were divided into three groups. An alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day...
Clinical significance of follow-up laboratory tests, performed at 6 weeks after the onset of Kawasaki disease
Il Ji Oh, Kyung Hee Moon, Myung Eun Hong, Yeon Soon Kim, Chang Woo Lee, Hyang Suk Yoon
Clin Exp Pediatr. 2006;49(6):672-676.   Published online June 15, 2006
Purpose : Low dose aspirin is used due to its antiplatelet effect for the subacute phase of Kawasaki disease(KD). It is usually used for 6-8 weeks, then various hematologic laboratory tests and follow up echocardiography for evaluating coronary abnormalities are performed. Our review investigated the usefulness of various follow up laboratory tests performed at 6 weeks after the onset of...
Effects of growth hormone treatment on glucose metabolism in idiopathic short stature
Seung Yeon Kwon, Duk-Hee Kim, Ho-Seong Kim
Clin Exp Pediatr. 2006;49(6):665-671.   Published online June 15, 2006
Purpose : To study the effects of growth hormone(GH) treatment on glucose metabolism and insulin resistance in children with idiopathic short stature(ISS). Methods : Glucose and insulin concentrations were measured during oral glucose tolerance test (OGTT) before and after GH treatment(0.6-0.7 IU/kg/week) in 20 patients with ISS. Insulin resistance was assessed by homeostasis model assessment(HOMA). Results : During OGTT, the mean...
Clinical characteristics and outcomes of status epilepticus as an initial seizure in children
Mi Jeong Kim, Young Ok Kim, Sun Hee Kim, Woo Yeon Choi, Hyung Suk Byun, Chan Jong Kim, Young Jong Woo
Clin Exp Pediatr. 2006;49(6):659-664.   Published online June 15, 2006
Purpose : To evaluate the morbidity and mortality of children with status epilepticus(SE) as an initial seizure and to compare these according to age groups. Methods : The 78 cases(38 cases <2 years and 38 cases ≥2 years) with SE as an initial seizure admitted to the Chonnam national university hospital from Jan. 2000 to Jan. 2004 were reviewed. Developmental profiles,...
Voiding cystourethrography in children with an initial episode of febrile urinary tract infection
Hae Jeong Lee, Won Deok Lee, Hyun Seok Kim, Tae Hong Kim, Joo Seok Lee, Kyung Lae Cho
Clin Exp Pediatr. 2006;49(6):653-658.   Published online June 15, 2006
Purpose : Because voiding cystourethrography(VCUG) is an invasive method, we studied whether VCUG could be postponed through evaluation of alternative non-invasive tests including renal ultrasonography and 99mTc-DMSA renal scan. Methods : We reviewed the medical records of 175 patients initially diagnosed with febrile urinary tract infection during the one year period of 1999, and compared 3-tests : renal ultrasongraphy, 99mTc-DMSA renal...
Necessity of 99mTc-dimercaptosuccinic acid scan in infants with low grade vesicoureteral feflux
Ji Yeon Koh, Ja Wook Koo
Clin Exp Pediatr. 2006;49(6):648-652.   Published online June 15, 2006
Objective : 99mTc-dimercaptosuccinic acid(DMSA) scan is considered to be the most sensitive examination for detection of renal scars. However, because of its high radiation exposure to the kidney and its limited usefulness for patients with low grade vesicoureteral reflux(VUR), some authors have suggested that DMSA scans should be reserved primarily for children with VUR grade 3 and above. The aim...
Correlation of inhalant MAST on chronically coughing children
Jung Min Yun, Eui Jung Roh, Jae Woo Lim, Eun Jung Choen, Kyoung Og Ko, Young Hyuk Lee
Clin Exp Pediatr. 2006;49(6):643-647.   Published online June 15, 2006
Purpose : Recently, incidences of chronic cough with allergic disease have been increased. The identification of specific allergens for chronically coughing children is significant for diagnosis, proper treatment and prevention. The aim of this study was to identify significant contributors for sensitization in chronically coughing children. Methods : A total of 106 children, aged 1-6 years, visiting for chronic cough(>3 weeks),...
Early and mid-term results of pulmonary valve reconstruction in surgical repair of tetralogy of Fallot; comparison with other techniques of right ventricular outflow reconstruction
Sheng Wen Wang, Young Seok Lee, Si Ho Kim, Tae Hong Kim, Ji Eun Ban, Hyoung Doo Lee, Yun Hee Chang, Si Chan Sung
Clin Exp Pediatr. 2006;49(6):635-642.   Published online June 15, 2006
Purpose : The purpose of this study is to determine whether the new pulmonary valve reconstruction technique prevents short-term postoperative pulmonary regurgitation and improves early and mid-term clinical outcome. Methods : We reviewed postoperative echocardiographic variables and chest X-ray films from 31 patients who had undergone valve reconstruction(pulmonary valve reconstruction group : PVR) for the repair of TOF between April 2000...
A study of the current(2003-2005) prevalence of anti-HBs and immunologic memory of hepatitis B vaccine in children from the central area of Korea
Young Won An, Eun Hee Chung, Insoo Rheem
Clin Exp Pediatr. 2006;49(6):630-634.   Published online June 15, 2006
Purpose : This study was conducted to assess the current(2003-2005) prevalence of anti-HBs and immunologic memory for Hepatitis B vaccine in children from the central area of Korea. Methods : Subjects were chosen from children and adolescents who received tests for hepatitis B surface antigen(HBsAg) and anti-HBs at Dankook University Hospital from March 2003 to May 2005. Among these, antibodies to...
Analysis of causative microorganisms and choice of antibiotics according to the onset of neonatal sepsis
June Seung Sung, Dong Yeon Kim, Sun Hee Kim, Hyung Suk Byun, Tai Ju Hwang, Young Youn Choi
Clin Exp Pediatr. 2006;49(6):623-629.   Published online June 15, 2006
Purpose : The mortality rate of neonatal sepsis has been decreased, however, the incidence has not significantly decreased because of increased invasive procedures. This study was designed to make guidelines for choosing antibiotics by analyzing the causative microorganisms and their antibiotics sensitivity test according to the onset of neonatal sepsis. Methods : One hundred seven cases of culture proven sepsis...
Serum high sensitivity C-reactive protein levels in obese middle school boys
Jae-Ho Jeong, Jae-Woo Lim, Eun-Jeong Cheon, Kyong-Og Ko, Young-Hyuk Lee
Clin Exp Pediatr. 2006;49(6):617-622.   Published online June 15, 2006
Purpose : High-Sensitivity C-reactive protein(hs-CRP) has been recognized as a very useful and sensitive predictor of the future risk of myocardial infarction. But the clinical significance of hs-CRP in children remains uncertain. To confirm the existence of obesity-induced vascular inflammation and the association between metabolic syndromes and elevation of CRP in children, we investigated the relationship among CRP, obesity, blood...
The timing of sexual maturation and secular trends of menarchial age in Korean adolescents
Mi Jung Park, In-Sook Lee, Eun-Kyung Shin, Hyojee Joung, Sung-Il Cho
Clin Exp Pediatr. 2006;49(6):610-616.   Published online June 15, 2006
Purpose : The purpose of this study was to evaluate the timing of sexual maturation and secular trends of menarchial age in Korean adolescents. Methods : Nine hundred eighty two school students and 119 university female students were included. Tanner's pubertal assessment method was applied using a self-assessment sheet with pictures for their developmental stages. A medical checkup database...
A survey of infant sleep positions associated with sudden infant death syndrome
Dong Jun Lee, So Ick Jang, Eun Jung Shim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo
Clin Exp Pediatr. 2006;49(6):602-609.   Published online June 15, 2006
Purpose : As the prone position is thought to be an important factor in sudden infant death syndrome(SIDS), this study was conducted to contribute to reducing SIDS by analyzing sleeping positions of infants. Methods : A face-to-face questionnaire was carried out with a total of 170 parents with a baby aged less than 6 months. Results : A total of 170 infants...
Effects of electromagnetic stimulation on neurogenesis and neuronal proliferation in rat hippocampal slice culture
Deok-Soo Kim, Eung Sang Choi, Soo Ahn Chae
Clin Exp Pediatr. 2006;49(5):558-564.   Published online May 15, 2006
Purpose : Transcranial electromagnetic stimulation(TMS) is a noninvasive method which stimulates the central nervous system through pulsed magnetic fields without direct effect on the neurons. Although the neurobiologic mechanisms of magnetic stimulation are unknown, the effects on the brain are variable according to the diverse stimulation protocols. This study aims to observe the effect of the magnetic stimulation with two...
Effect of GnRH analogue on predicted adult height in girls with early puberty
Byung-Hoon Ahn, Heon-Seok Han
Clin Exp Pediatr. 2006;49(5):552-557.   Published online May 15, 2006
Purpose : The recent results observed in precocious puberty and the hope that interrupting puberty might increase adult height have led to an attempt to use GnRH agonist(GnRHa) in children with premature puberty and a poor growth prognosis. We aimed to analyze the growth promoting effect of GnRHa in girls with early puberty and low predicted adult height(PAH). Methods : Thirty...
Polymorphisms of the CTLA-4 promoter(-318) and exon 1(＋49) genes with atopic dermatitis in Korean children
Tae Won Song, Hea Sun Yang, Kyung Eun Lee, Kyung Won Kim, Eun Soo Kim, Myung Hyun Sohn, Kyu-Earn Kim, M.D
Clin Exp Pediatr. 2006;49(5):545-551.   Published online May 15, 2006
Purpose : The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(＋49). Methods : The CTLA-4 promoter(-318 T/C) and exon 1(＋49 A/G) polymorphisms were genotyped via restriction fragment...
NT-pro BNP : A new diagnostic screening tool for Kawasaki disease
Hyunju Lee, Heejung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2006;49(5):539-544.   Published online May 15, 2006
Purpose : The purpose of this study was to determine whether N-terminal fragment of B-type natriuretic peptide(NT-proBNP) may be used to differentiate acute Kawasaki disease(KD) from other clinically similar diseases. Methods : Using electrochemiluminescence immunoassay, NT-proBNP concentrations were measured in the acute phase within 10 days after the onset of KD(n=58) and in the convalescent phase, 60 to 81 days after...
A study of neuropeptides related to headaches in children with meningeal irritation signs
Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
Clin Exp Pediatr. 2006;49(5):533-538.   Published online May 15, 2006
Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We...
Clinical study in children with cerebral palsy associated with or without epilepsy
Yongjoo Ahn, Hyejeon Chung, Suk Youn, Euihyun Cho, Sajun Chung
Clin Exp Pediatr. 2006;49(5):529-532.   Published online May 15, 2006
Purpose : To study the spectrum of epilepsy in children with cerebral palsy. Methods : A total of 93 consecutive patients with cerebral palsy(CP) were retrospectively suited. Criteria for inclusion were a follow-up period of at least 2 years. The study examined the correlation between the incidence of epilepsy and seizure types in the different forms of CP. Other factors associated...
Relationship between depression and resilience in adolescents with congenital heart disease
Ju Ryoung Moon, Yoen Yi Jung, June Huh, I-Seok Kang, Seung Woo Park, Ji-Hyuk Yang, Tae-Gook Jun, Myung Ja Kim, Heung Jae Lee
Clin Exp Pediatr. 2006;49(5):523-528.   Published online May 15, 2006
Purpose : The purpose of this study was to investigate the relationship between depression and resilience in adolescents with congenital heart disease(CHD) and to identify the variables associated with depression. Methods : The Resilience Scale(cronbach’s α=0.92), Children's Depression Inventory(cronbach’s α= 0.72) and Maternal Behavior Research Instrument(cronbach’s α=0.88) were applied and analyzed to assess depression and resilience among 231 adolescents after...
Jagged1 mutation analysis in Alagille syndrome patients
Jae Sung Ko, Hye Ran Yang, Kyung Mo Kim, Jeong Kee Seo
Clin Exp Pediatr. 2006;49(5):519-522.   Published online May 15, 2006
Purpose : Alagille syndrome is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region. The Jagged1(JAG1) gene, which encodes a ligand of Notch, has been found mutated in Alagille syndrome. The aim of the study was to investigate the mutation analysis of JAG1 gene in Korean patients with Alagille syndrome. Methods : Genomic DNA...
Genotype of rotavirus isolated from patients with rotaviral enteritis and neurological complications
Jae Hyung Choi, Jung Mi Kim, Yong Joo Kim, Jae Won Oh, Chang Lyul Kim, Myung Kul Yum, In Joon Sul, Jung Oak Kang
Clin Exp Pediatr. 2006;49(5):513-518.   Published online May 15, 2006
Purpose : This study was undertaken to determine the differences in genotypes of rotavirus and their incidence between patients with acute rotaviral enteritis who suffered neurologic complications and those who did not suffer neurologic complications. Methods : Among the 82 patients with rotaviral enteritis whose genotype was analyzed, 71 patients were not associated with neurologic complications(neurology(－) group), and eleven patients were...
Neonatal hearing screening in a neonatal intensive care unit using distortion product otoacoustic emissions
Do Young Kim, Sung Shin Kim, Chang Hwi Kim, Shi Chan Kim
Clin Exp Pediatr. 2006;49(5):507-512.   Published online May 15, 2006
Purpose : Early detection and intervention of hearing impairment is believed to improve speech and language development and behavior of children. The aim of this preliminary study was to determine the prevalence of hearing impairments, and to identify the association of risk factors relating to refer response in high risk neonates who were screened using distortion product otoacoustic emissions (DPOAE). Methods...
Clinical aspects of an outbreak of Serratia marcescens infections in neonates
Min-Jung Sung, Chul-Hun Chang, Yeon-Kyong Yoon, Su-Eun Park
Clin Exp Pediatr. 2006;49(5):500-506.   Published online May 15, 2006
Purpose : We evaluated an outbreak of Serratia marcescens infections in 24 neonates in a neonatal intensive care unit(NICU). Methods : From January to August, 2004 a nosocomial outbreak of S. marcescens occurred in our NICU. We describe the clinical characteristics of the outbreak and analyse the risk factors for infections with S. marcescens. After the outbreak stopped, 7 isolates...
Outbreak of Acinetobacter septicemia in a neonatal intensive care unit
Myo Jing Kim, Hye Jin Lee, Sang Hee Son, Jae Won Huh
Clin Exp Pediatr. 2006;49(5):494-499.   Published online May 15, 2006
Purpose : Acinetobacter baumannii is increasingly recognized as an important cause of nosocomial infection, especially in neonatal intensive care units. But little is known about the clinical significance and hospital epidemiology of Acinetobacter species other than A. baumannii. The objective of this study is to describe the clinical characteristics and epidemiology of septicemia due to Acinetobacter species other than A....
Risk factors and clinical characteristics of necrotizing enterocolitis in full-term newborns
Young Mi Jeoung, Hyun Gon Je, Sang Hee Son
Clin Exp Pediatr. 2006;49(5):489-493.   Published online May 15, 2006
Purpose : The purpose of this study was to determine those factors which could contribute to the development of necrotizing enterocolitis(NEC) in fullterm. Methods : We retrospectively reviewed the medical record of 20 full-terms with NEC(≥modified Bell's staging criteria IIa) who were admitted to the Neonatal Intensive Care Unit of Il Sin Christian hospital from January 1998 through July 2005, and...
Factors which contribute to time of first stool and first urine passage in Newborns
Hye Jin Lee, Hyun Gon Jae, Sang Hee Son
Clin Exp Pediatr. 2006;49(5):482-488.   Published online May 15, 2006
Purpose : To evaluate the factors which contribute to the time of the first stool and the first urine passage. Methods : We retrospectively reviewed a chart of 1,221 infants ≥34 weeks of gestational age admitted to the normal newborn nursery of Il Sin Christian Hospital, Busan, from November 2004 to April 2005. We compared the time to first stool and...
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