• Search
  • Advanced Search

Original article

  • HOME
  • ARTICLE CATEGORY
  • Original article
Article category
Original Article
Ocular manifestations in Leigh syndrome
Kyo Ryung Kim, Suk Ho Byeon, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
Clin Exp Pediatr. 2010;53(2):163-166.   Published online February 15, 2010
Purpose : Leigh syndrome is a typical type of mitochondrial disease. This study was conducted to analyze the types of ophthalmologic symptoms and results of funduscopy conducted in the ophthalmologic examination of patients with Leigh syndrome. Methods : Funduscopy was conducted on 24 subjects, who were chosen among those diagnosed as having mitochondrial respiratory chain complex defect and who were clinically...
Clinical disease characteristics according to karyotype in Turner syndrome
Chae Young Yeo, Chan Jong Kim, Young Jong Woo, Dae Yeol Lee, Min Sun Kim, Eun Young Kim, Jong Duck Kim
Clin Exp Pediatr. 2010;53(2):158-162.   Published online February 15, 2010
Purpose : Turner syndrome (TS) is a disorder in which various anomalies can be accompanied, especially cardiovascular, renal, thyroid and auditory problems. The aim of this study is to identify the incidence of these disorders in patients with TS according to karyotype. Methods : We reviewed medical records of 90 patients with TS diagnosed by chromosomal analysis in 4 hospitals...
Clinical characteristics of vitamin D deficiency rickets in infants and preschool children
Kyoung Huh, Mi Kyeong Woo, Jung Rim Yoon, Gyu Hong Shin, Myoung Jae Chey, Mi Jung Park
Clin Exp Pediatr. 2010;53(2):152-157.   Published online February 15, 2010
Purpose : Vitamin D deficiency rickets is a significant public health problem that results from insufficient exposure to sunlight and inadequate vitamin D supplementation. The purpose of this study is to identify the clinical characteristics of vitamin D deficiency rickets in infants. Methods : Data of 35 infants diagnosed as vitamin D deficiency rickets at Sanggye-Paik Hospital, Seoul, Korea, from March...
A study of factors influencing advanced puberty
Yong Jun Park, Chang Min Moon, Hwang Jae Yoo
Clin Exp Pediatr. 2010;53(2):146-151.   Published online February 15, 2010
Purpose : The purpose of this study was to evaluate the timing of puberty and the factors inducing advanced puberty in elemental school students of low grades. Methods : The 1st, 2nd, and 3rd grade elemental students from the Goyang province were randomly selected, and their sexual maturation rate was assessed by physical examination. After obtaining an informed consent, a questionnaire...
Long-term outcomes of infantile spasms
Seak Hee Oh, Eun-Hye Lee, Min-Hee Joung, Mi-Sun Yum, Tae-Sung Ko
Clin Exp Pediatr. 2010;53(1):80-84.   Published online January 15, 2010
Purpose : The aims of this study were to investigate the long-term outcomes in children with infantile spasms (IS) and to identify the prognostic factors influencing their neurodevelopment. Methods : We retrospectively evaluated seventy two children over five years old who were treated for IS at Asan Medical Center, Seoul, Korea, between 1994 and 2007. Forty-three children were contacted by telephone...
Left ventricular dysfunction measured by tissue Doppler imaging and strain rate imaging in hypertensive adolescents
Hye Mi Ahn, Sun Ok Jung, Jung Hyun Kwon, Young Mi Hong
Clin Exp Pediatr. 2010;53(1):72-79.   Published online January 15, 2010
Purpose : Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension. Diastolic dysfunction is associated with increased cardiovascular risk. Tissue Doppler imaging (TDI)-derived tissue velocity and strain rate are new parameters for assessing diastolic dysfunction. The aim of this study is to determine whether TDI and strain rate imaging (SRI) would improve the ability to...
Mumps outbreak in Incheon, Korea, 2009
Seon Young Cho, Soo Young Lee, Jin Han Kang,, Hui Seung Hwang
Clin Exp Pediatr. 2010;53(1):67-71.   Published online January 15, 2010
Purpose : Recently, we have noticed an increase in the number of patients with mumps in Incheon, Korea. The aim of this study is to estimate the regional trend in mumps incidence and to evaluate the factors related to the recent increase. Methods : We reviewed the medical records of 66 patients with mumps who had been admitted to Incheon St....
Oseltamivir efficacy, side effects, and safety in children with influenza
Eun Sun Seo, Geun Hwa Park, Sung Won Kim, Sung Won Kim, Woo Sik Jung, Kyung Soon Cho, Yeon Gyeong Park, Chang Kyu Lee, Chun Kang, Joo Yeon Lee, Woo Young Choi
Clin Exp Pediatr. 2010;53(1):56-66.   Published online January 15, 2010
Purpose : Although oseltamivir is widely used for treatment of influenza, few clinical studies of its efficacy and resistance have been performed in Korea. We evaluated the safety, side effects, and efficacy of oseltamivir treatment in Korean pediatric patients. Methods : We analyzed 321 children diagnosed with influenza at Busan St. Mary's Medical Center, Korea, between January 2008 and June...
Regional outbreak of staphylococcal scalded skin syndrome in healthy children
Hyun Jeong Do, Eun Sil Park, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn, Ji Hyun Seo
Clin Exp Pediatr. 2010;53(1):48-55.   Published online January 15, 2010
Purpose : Staphylococcal scalded skin syndrome (SSSS) is a relatively uncommon superficial blistering skin disease that is due to Staphylococcus aureus. We had experienced a regional outbreak of SSSS over 3 years in healthy children. Methods : We retrospectively reviewed the medical records of those patients diagnosed as SSSS. Most of neonatal cases were nosocomial infections and excluded from the...
Serum interleukin-6, tumor necrosis factor-α and adiponectin levels in Kawasaki disease
Jung Ahn, Han Gyu Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2010;53(1):41-47.   Published online January 15, 2010
Purpose : Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, lipid profile, and C reactive protein (CRP), and...
Influence of histologic chorioamnionitis and funisitis on the level of peripheral blood C-reactive protein at birth in preterm infants
Do-Hyun Kim, Heun Ji Lee, Hee Sup Kim, Byoung Hoon Yoo
Clin Exp Pediatr. 2010;53(1):33-40.   Published online January 15, 2010
Purpose : The objective of this study is to determine the change of C-reactive protein (CRP) levels in the peripheral blood of preterm infants at birth according to the stage of intrauterine inflammation. Methods : A total of 187 infants (<32 weeks of gestation) were divided into a “no histologic chorioamnionitis” [HCAM (-), n=85] group and a “histologic chorioamnionitis” [HCAM...
Analysis on the cause of eosinophilia in a neonatal intensive care unit
Jeoung Young Kim, Hyo Bin Im, Min Jung Sung, Sang Hee Son, Son Sang Seo
Clin Exp Pediatr. 2010;53(1):28-32.   Published online January 15, 2010
Purpose : Although eosinophilia is a common laboratory finding in many neonatal intensive care units (ICUs), its causative mechanisms remain obscure. We aimed to determine the causes of eosinophilia in the neonatal ICU environment. Methods : Serial eosinophil counts were determined weekly for 288 hospitalized, appropriately grown neonates. Infants were divided into four groups according to gestational age, and the...
Comparative study on effects of volume-controlled ventilation and pressure-limited ventilation for neonatal respiratory distress syndrome
Jae Jin Kim, Mun Jung Hwang, Sang Geel Lee
Clin Exp Pediatr. 2010;53(1):21-27.   Published online January 15, 2010

Purpose:In contrast with traditional time-cycled, pressure-limited ventilation, during volume-controlled ventilation, a nearly constant tidal volume is delivered with reducing volutrauma and the episodes of hypoxemia. The aim of this study was to compare the efficacy of pressure-regulated, volume controlled ventilation (PRVC) to Synchronized intermittent mandatory ventilation (SIMV) in VLBW infants with respiratory distress syndrome (RDS). Methods : 34 very low birth...
Analysis of gonadotropin-releasing hormone (GnRH) test results in girls with precocious puberty
Jung Yun Choi, Hyun-Ju Kang, Won Kyoung Cho, Kyoung Soon Kim, So Hyun Park, Seung Hoon Hahn, Min Ho Jung, Byung Kyu Suh, Byung Churl Lee
Clin Exp Pediatr. 2009;52(12):1377-1382.   Published online December 15, 2009
Purpose : The gonadotropin-releasing hormone (GnRH) test results of girls with precocious puberty were analyzed to determine whether this test can efficiently and clearly differentiate between central precocious puberty (CPP) and other disorders. Methods : Clinical and laboratory data of 54 girls with precocious pubertal signs were reviewed. Intravenous GnRH test was performed with blood samples obtained at 0, 30,...
Effect of GnRH analogue on the bone mineral density of precocious or early pubertal girls
Jeong Sook Lim, Heon-Seok Han
Clin Exp Pediatr. 2009;52(12):1370-1376.   Published online December 15, 2009
Purpose : Treatment of precocity with gonadotropin releasing hormone analogue (GnRHa) might theoretically exert a detrimental effect on the bone mass during pubertal development. We investigated the short-term changes in bone mineral density (BMD) during GnRHa treatment and the enhancement in the changes with the co-administration of GnRHa and human growth hormone (hGH). Methods : Forty girls with precocious or...
The changes in signal-averaged electrocardiogram after surgical correction of congenital heart disease
Yeo Hyang Kim, Hee Jung Choi, Gun Jik Kim, Joon Yong Cho, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2009;52(12):1364-1369.   Published online December 15, 2009
Purpose : To analyze abnormal ventricular activation in childhood congenital heart disease induced by postoperative changes in ventricular volume and pressure and ventricular scar formation using signal-averaged electrocardiography (SAECG). Methods : Fifty-two patients who had undergone open heart surgery (OHS) were enrolled. Patients were divided into the following 3 groups: right ventricular volume overload (atrial septal defect, group1), left ventricular...
Detection of nasopharyngeal carriages in children by multiplex reverse transcriptase-polymerase chain reaction
Ji Hye Shin, Hye Young Han, Sun Young Kim
Clin Exp Pediatr. 2009;52(12):1358-1363.   Published online December 15, 2009
Purpose : The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in children using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. Methods : We obtained nasopharyngeal swabs from 33 children without any underlying disease from July 25 to July 28, 2008. The children were free from the signs of respiratory tract infections at the...
Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis
Dae Sun Jo, Ji Hye Han, Sun Young Kim, Min Sun Kim, Ho Keun Yi, Dae-Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(12):1348-1357.   Published online December 15, 2009
Purpose : The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis. Methods : Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets,...
Taurine exerts neuroprotective effects via anti-apoptosis in hypoxic-ischemic brain injury in neonatal rats
Ji Eun Jeong, Tae Yeol Kim, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
Clin Exp Pediatr. 2009;52(12):1337-1347.   Published online December 15, 2009
Purpose : Taurine (2-aminoethanesulfonic acid) is a simple sulfur-containing amino acid. It is abundantly present in tissues such as brain, retina, heart, and skeletal muscles. Current studies have demonstrated the neuroprotective effects of taurine, but limited data are available for such effects during neonatal period. The aim of this study was to determine whether taurine could reduce hypoxic-ischemic (HI) cerebral...
Clinical characteristics and courses of congenital muscular torticollis
Kyong Eun Choi, Hee Chul Lee, So Young Youn, Jung Mi Chun, Son Moon Shin, Byung Hee Han, Yong Taek Lee
Clin Exp Pediatr. 2009;52(11):1273-1278.   Published online November 15, 2009
Purpose : Congenital muscular torticollis (CMT), a common musculoskeletal disorder in infants, is characterized by the rotation and flexion deformity of the neck caused by sternocleidomastoid muscle shortening. We investigated the clinical courses and perinatal risk factors of CMT. Methods : Less than 6-month-old patients (98; M:F = 60:38) diagnosed with CMT between February 2007 and August 2008 were classified...
The quality control and acceptability of spirometry in preschool children
Hyun Kyong Seo, Sun Jung Chang, Da Woon Jung, Young Sun Wee, Hye Mi Jee, Ji Young Seo, Man Yong Han
Clin Exp Pediatr. 2009;52(11):1267-1272.   Published online November 15, 2009
Purpose : We examined the ability of preschool aged children to meet the American Thoracic Society (ATS) and European Resiratory Society (ERS) goals for spirometry quality and tried to find out the major factor for improving the rate of success of spiromety test in this age group. Methods : Spirometry was performed in 2-6 aged 155 children with chronic cough or...
Polymorphisms of the NR3C1 gene in Korean children with nephrotic syndrome
Hee Yeon Cho, Hyun Jin Choi, So Hee Lee, Hyun Kyung Lee, Hee Kyung Kang, Il Soo Ha, Yong Choi, Hae Il Cheong
Clin Exp Pediatr. 2009;52(11):1260-1266.   Published online November 15, 2009
Purpose : Idiopathic nephrotic syndrome (NS) can be clinically classified as steroid-sensitive and steroid-resistant. The detailed mechanism of glucocorticoid action in NS is currently unknown. Methods : In this study, we investigated 3 known single nucleotide polymorphisms (SNPs) (ER22/23EK, N363S, and BclI) of the glucocorticoid receptor gene (the NR3C1 gene) in 190 children with NS using polymerase chain reaction-restriction fragment...
Economic evaluation of a weekly administration of a sustained-release injection of recombinant human growth hormone for the treatment of children with growth hormone deficiency
Hye-Young Kang, Duk Hee Kim, Sei-Won Yang, Yoon-Nam Kim, Miseon Kim
Clin Exp Pediatr. 2009;52(11):1249-1259.   Published online November 15, 2009
Purpose : From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency. Methods : Health-related utility for GH therapy was measured based on the visual analogue scale. During July...
Association between Kawasaki disease and acute respiratory viral infections
Eun Young Cho, Byung Wook Eun, Nam Hee Kim, Jina Lee, Eun Hwa Choi, Hoan Jong Lee, Jung Yun Choi
Clin Exp Pediatr. 2009;52(11):1241-1248.   Published online November 15, 2009
Purpose : The etiology of Kawasaki disease (KD) is still unknown. Recently, an association between human coronavirus NL63 (HCoV-NL63) and KD was implicated. Hence, we attempted to determine the association between KD and acute respiratory viral infections. Methods : Nasopharyngeal aspirate samples were obtained from 54 patients diagnosed with KD at the Seoul National University (SNU) Children’s Hospital and SNU-Bundang Hospital...
Molecular identification and clinical features of enteroviral infection in children of central Korea: An overview of enteroviral epidemiology between spring 2005 and autumn 2006
Eui Jung Roh, Yong Man Jin, Eun Hee Chung, Young Pyo Chang, Woo Sung Park, Kwisung Park, Young Mee Jee
Clin Exp Pediatr. 2009;52(11):1234-1240.   Published online November 15, 2009
Purpose : Enteroviruses (EVs) are commonly known to cause infection, especially in infants and children. This report presents an overview of enterovirus epidemiology in central Korea. Methods : From the spring of 2005 to the autumn of 2006, we collected the cerebrospinal fluid (CSF) and stool samples from the pediatric patients with a febrile illness or suspected meningitis who were...
The relationship between the time from arrival at a hospital to delivery and the occurrence of cerebral palsy in premature infants of less than 34 weeks of gestational age
Jae Woong Whang, A Lum Heo, Soo Hyun Koo, Hae Jung Lee, Jun Wha Lee, Joo Seok Lee, Kyung Lae Cho
Clin Exp Pediatr. 2009;52(11):1228-1233.   Published online November 15, 2009
Purpose : This study aimed to evaluate whether a shorter time from the arrival at a hospital to delivery is related to the occurrence of cerebral palsy in premature infants of less than 34 weeks of gestational age. Methods : We studied 142 newborns of less than 34 weeks of gestational age. The time from the arrival at the hospital...
Study on the neurodevelopmental predictors for the results of the Bayley Scales of Infant Development II in high-risk neonates
Mi Kyeong Woo, Dong Wook Kim, Kyoung Huh, Gyu Hong Shim, Myoung Jae Chey
Clin Exp Pediatr. 2009;52(11):1221-1227.   Published online November 15, 2009
Purpose : To identify the risk factors for poor neurodevelopmental outcomes in high-risk neonates. Methods : We studied 94 infants admitted to the neonatal intensive care unit at the Sanggye Paik Hospital between January 2002 and November 2005 and evaluated the follow-up data. The following events were considered as risk factors: ≤32 weeks of gestation, very low birth weight, Apgar scores...
Clinical experience of therapeutic effect of peritoneal drainage on intestinal perforation in preterm infants
Jun Seok Lee, Kyo Yeon Koo, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee, Seung Hoon Choi
Clin Exp Pediatr. 2009;52(11):1216-1220.   Published online November 15, 2009
Purpose : To analyze and compare various cases in which peritoneal drainage was used as the primary treatment method in preterm infants with intestinal perforation. Methods : Among the preterm infants of less than 28 weeks of gestation who were admitted to the neonatal intensive care unit (NICU) at the Gangnam Severance Hospital from April 2006 to April 2009, 7 who...
A multidisciplinary approach for the treatment of child abuse in Korea
Bong Kyu Song, Do Kyun Kim, Hye Young Park, Jun Won Hwang, Young Ho Kwak
Clin Exp Pediatr. 2009;52(11):1207-1215.   Published online November 15, 2009
Purpose : To review and determine the complications in 76 child abuse cases recorded by a multidisciplinary hospital- based child protection team between 1987 and 2007. Methods : We retrospectively reviewed the reports and medical records of child abuse cases maintained by a university hospital-based child protection team. We devised a questionnaire for standardized interviews with the victims’ guardians to...
Predictive indicators of coronary artery complications in Kawasaki disease
Min Jee Park, In-sang Jeon, Hann Tchah, Kang Ho Cho, Mi-Jin Jung, Deok Young Choi
Clin Exp Pediatr. 2009;52(10):1161-1166.   Published online October 15, 2009
Purpose : Kawasaki disease—the most common cause of acquired heart disease in children—incidence is increasing yearly. Therefore, we evaluated the predictive indicators of coronary complications of Kawasaki disease based on clinical and laboratory data. Methods : Between January 2005 and March 2008, of the 201 children with Kawasaki disease treated at the Gil Hospital of Gachon University of Medicine and...
TOPICS

Browse all articles >

ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
FOR CONTRIBUTORS
ABOUT
Editorial Office
Korean Pediatric Society
#1606 Seocho World Officetel, 19 Seoun-ro, Seocho-ku, Seoul 06732, Korea
Tel: +82-2-3473-7306    Fax: +82-2-3473-7307    E-mail: office@e-cep.org                

Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)

Copyright © 2026 by Korean Pediatric Society.      Developed in M2PI