Article 60(7); Jul 2017
Review Article
Neonatology (Perinatology)
Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia?
Chang Won Choi
Clin Exp Pediatr. 2017;60(7):203-207.   Published online July 31, 2017

Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, fetal lung inflammation induced by chorioamnionitis has been considered to be one of the major pathogenetic...

Original Articles
Cardiology
Association of Toll-like receptor 2-positive monocytes with coronary artery lesions and treatment nonresponse in Kawasaki disease
Soo Jung Kang, Nam Su Kim
Clin Exp Pediatr. 2017;60(7):208-215.   Published online July 31, 2017
Purpose

Activation of Toll-like receptor 2 (TLR2) present on circulating monocytes in patients with Kawasaki disease (KD) can lead to the production of proinflammatory cytokines and interleukin-10 (IL-10). We aimed to determine the association of the frequency of circulating TLR2+/CD14+ monocytes (FTLR2%) with the outcomes of KD, as well as to compare FTLR2% to the usefulness of sIL-10.

Methods

The FTLR2% in patients...

Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease
Jae Sung Jun, Young Kwon Jung, Dong Won Lee
Clin Exp Pediatr. 2017;60(7):216-220.   Published online July 31, 2017
Purpose

Vitamin D is associated with various pathological conditions such as cardiovascular diseases and cancer. We investigated the relationship between vitamin D and Kawasaki disease (KD).

Methods

We performed a retrospective review of the medical records of patients with KD between February 2013 and March 2016 in Daegu Fatima Hospital. Study participants were grouped according to vitamin D serum concentration. Group 1 included...

Infection
Uropathogenic Escherichia coli ST131 in urinary tract infections in children
Ki Wook Yun, Mi-Kyung Lee, Wonyong Kim, In Seok Lim
Clin Exp Pediatr. 2017;60(7):221-226.   Published online July 31, 2017
Purpose

Escherichia coli sequence type (ST) 131, a multidrug-resistant clone causing extraintestinal infections, has rapidly become prevalent worldwide. However, the epidemiological and clinical features of pediatric infections are poorly understood. We aimed to explore the characteristics of ST131 Escherichia coli isolated from Korean children with urinary tract infections.

Methods

We examined 114 uropathogenic E. coli (UPEC) isolates from children hospitalized at Chung-Ang University...

Neurology
Effects of low-dose topiramate on language function in children with migraine
Seung-A Han, Eu Jeen Yang, Younghwa Kong, Chan-Uhng Joo, Sun Jun Kim
Clin Exp Pediatr. 2017;60(7):227-231.   Published online July 31, 2017
Purpose

This study aimed to verify the safety of low-dose topiramate on language development in pediatric patients with migraine.

Methods

Thirty newly diagnosed pediatric patients with migraine who needed topiramate were enrolled and assessed twice with standard language tests, including the Test of Language Problem Solving Abilities (TOPs), Receptive and Expressive Vocabulary Test, Urimal Test of Articulation and Phonology, and computerized speech laboratory...

Case Report
Pulmonology
A pediatric case of relapsed pulmonary alveolar proteinosis despite successful whole lung lavage
Seung Young Jin, Hye Ri Yun, Yun Jung Choi, Jun Dong Park, Jin Tae Kim, Chang Hyun Kang, Young Sik Park, Young Hun Choi, Woo Sun Kim, Dong In Suh
Clin Exp Pediatr. 2017;60(7):232-236.   Published online July 31, 2017

Pulmonary alveolar proteinosis (PAP) is a rare disease in children characterized by intra-alveolar accumulation of surfactant proteins, which severely reduces gaseous exchange. Whole lung lavage (WLL) is the preferred technique for the treatment of severe PAP. Herein, we present a pediatric case of PAP treated with WLL. An 11-year-old boy was admitted with the chief complaint of a dry cough...

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