- Original Article
- Nephrology (Genitourinary)
- Impaired angiogenesis in the enalapril-treated neonatal rat kidney
- Hyung Eun Yim, Kee Hwan Yoo, Eun Soo Bae, Young Sook Hong, Joo Won Lee
- Clin Exp Pediatr. 2016;59(1):8-15. Published online January 22, 2016
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Purpose Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney.
Methods Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular...
