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- Original Article
- Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia
- Jeong Eun Shin, Soon Min Lee, Mi-Jung Lee, Jungho Han, Joohee Lim, Haerin Jang, Ho Seon Eun, Min Soo Park, Soo Yeon Kim, Myung Hyun Sohn, Ji Ye Jung, Kyung Won Kim
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Question: Is bronchopulmonary dysplasia (BPD) associated with functional/structural abnormalities later in life?
Finding: School-aged children with severe BPD had abnormalities on pulmonary function tests and lung computed tomography despite no subjective respiratory symptoms; however, only prenatal oligohydramnios and prolonged ventilator use were associated with abnormal lung function.
Meaning: Long-term monitoring of preterm infants’ lung health is essential, especially for those with prenatal oligohydramnios or prolonged ventilator use. -
DOI: https://doi.org/10.3345/cep.2023.01053 [Epub ahead of print]
- Other
- Risk factors and screening timing for developmental dysplasia of the hip in preterm infants
- Ga Won Jeon, Hye Jung Choo, Yong Uk Kwon
- Clin Exp Pediatr. 2022;65(5):262-268. Published online November 5, 2021
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Question: When is the best screening timing and what is the risk factor for developmental dysplasia of the hip (DDH) in preterm infants?
Finding: Ultrasonography performed earlier than 38 weeks of postmenstrual age caused unnecessary subsequent ultrasonography. DDH did not occur predominantly on the left side or in breech infants.
Meaning: The screening timing, etiology, and risk factors for DDH in preterm infants are somewhat different from those in term infants.
- Neonatology (Perinatology)
- The protective effect of CXC chemokine receptor 2 antagonist on experimental bronchopulmonary dysplasia induced by postnatal systemic inflammation
- Seung Hyun Lee, Chang Won Choi
- Clin Exp Pediatr. 2021;64(1):37-43. Published online July 15, 2020
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Question: Can CXC chemokine receptor 2 (CXCR2) antagonist preserve alveolarization by attenuating the inflammation induced by systemic lipopolysaccharide (LPS) administration in a rat model of bronchopulmonary dysplasia (BPD)?
Finding: CXCR2 antagonist significantly decreased neutrophil counts in bronchoalveolar lavage fluid and peripheral blood induced by systemic LPS administration and restored alveolarization in newborn rats.
Meaning: CXCR2 antagonist protected the lungs from the inflammation in a rat model of BPD.
- Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants
- Eui Young Lee, Sung Shin Kim, Ga Young Park, Sun Hyang Lee
- Clin Exp Pediatr. 2020;63(2):56-62. Published online February 6, 2020
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Question: Does RBC transfusion affect the short-term outcomes of VLBW infants?
Finding: The results showed that RBC transfusion was significantly related to the incidence of BPD (OR, 5.42; P<0.001) and NEC (OR, 3.40; P=0.009).
Meaning: Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administering RBC transfusions.
- Review Article
- Neonatology (Perinatology)
- Bronchopulmonary dysplasia: how can we improve its outcomes?
- Tae-Jung Sung
- Clin Exp Pediatr. 2019;62(10):367-373. Published online May 17, 2019
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Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the...
- Original Article
- Neonatology (Perinatology)
- Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants
- Ian Kim, Sung Shin Kim, Jee In Song, Seock Hwa Yoon, Ga Young Park, Yong-Wha Lee
- Clin Exp Pediatr. 2019;62(5):166-172. Published online October 24, 2018
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Purpose: This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs: <1,500 g) and to determine the association between vitamin D level and respiratory morbidity. Methods: A retrospective study was conducted at Soonchunhyang University Bucheon Hospital between November 2013 and November 2017. We collected blood samples and data on respiratory morbidity from 230 VLBWIs on the first...
- Review Article
- Neonatology (Perinatology)
- Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia?
- Chang Won Choi
- Clin Exp Pediatr. 2017;60(7):203-207. Published online July 31, 2017
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Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, fetal lung inflammation induced by chorioamnionitis has been considered to be one of the major pathogenetic...
- Respiratory support with heated humidified high flow nasal cannula in preterm infants
- Ga Won Jeon
- Clin Exp Pediatr. 2016;59(10):389-394. Published online October 17, 2016
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The incidence of bronchopulmonary dysplasia (BPD) has not decreased over the last decade. The most important way to decrease BPD is by weaning the patient from the ventilator as soon as possible in order to reduce ventilator-induced lung injury that underlies BPD, and by using a noninvasive ventilator (NIV). Use of a heated, humidified, high flow nasal cannula (HHHFNC), which...
- Original Article
- Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants
- Choae Lee, Jaewoo An, Ji Hee Kim, Eun Sun Kim, Soo Hyun Kim, Yeon Kyung Cho, Dong Hyun Cha, Man Yong Han, Kyu Hyung Lee, Youn Ho Sheen
- Clin Exp Pediatr. 2015;58(11):415-420. Published online November 22, 2015
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Purpose Bronchopulmonary dysplasia (BPD) is characterized by inflammation with proteolytic damage to the lung extracellular matrix. The results from previous studies are inconsistent regarding the role of proteinases and antiproteinases in the development of BPD. The aim of the present study was to investigate whether matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-1 levels in the serum of...
- The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia
- Sang Bum Kim, Jang Hoon Lee, Juyoung Lee, Seung Han Shin, Ho Sun Eun, Soon Min Lee, Jin A Sohn, Han Suk Kim, Byung Min Choi, Min Soo Park, Kook In Park, Ran Namgung, Moon Sung Park
- Clin Exp Pediatr. 2015;58(9):347-353. Published online September 21, 2015
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Purpose The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD).
Methods The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA)....
- The relationship between eosinophilia and bronchopulmonary dysplasia in premature infants at less than 34 weeks' gestation
- Joo Yun Yang, Jihei Cha, So-Yeon Shim, Su Jin Cho, Eun Ae Park
- Clin Exp Pediatr. 2014;57(4):171-177. Published online April 30, 2014
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Purpose Eosinophilia is common in premature infants, and its incidence increases with a shorter gestation period. We investigated the clinical significance of eosinophilia in premature infants born at <34 weeks gestation.
Methods We analyzed the medical records of premature infants born at <34 weeks gestation who were admitted to the neonatal intensive care unit at Ewha Womans University Mokdong Hospital between January 2003...
- Serological investigation of
Ureaplasma urealyticum in Korean preterm infants - Ho Seon Eun, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2013;56(11):477-481. Published online November 27, 2013
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Purpose Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among variousUreaplasma urealyticum serovars. The aim of this study was to determineU. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD).Methods Three hundred forty-four preterm infants with a gestational age...
- Case Report
- A case of thanatophoric dysplasia type I with an R248C mutation in the
FGFR3 gene - Eun Jung Noe, Han Wook Yoo, Kwang Nam Kim, So Yeon Lee
- Clin Exp Pediatr. 2010;53(12):1022-1025. Published online December 31, 2010
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Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from the mutation in fibroblast growth factor receptor 3 (FGFR-3) gene which is located on the...
- Review Article
- Lung interstitial cells during alveolarization
- Chang Won Choi
- Clin Exp Pediatr. 2010;53(12):979-984. Published online December 31, 2010
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Recent progress in neonatal medicine has enabled survival of many extremely low-birth-weight infants. Prenatal steroids, surfactants, and non-invasive ventilation have helped reduce the incidence of the classical form of bronchopulmonary dysplasia characterized by marked fibrosis and emphysema. However, a new form of bronchopulmonary dysplasia marked by arrest of alveolarization remains a complication in the postnatal course of extremely low-birth-weight infants....
- Pulmonary hypertension in infants with bronchopulmonary dysplasia
- Gi Beom Kim
- Clin Exp Pediatr. 2010;53(6):688-693. Published online June 23, 2010
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An increase in the number of preterm infants and a decrease in the gestational age at birth have resulted in an increase in the number of patients with significant bronchopulmonary dysplasia (BPD) and secondary pulmonary hypertension (PH). PH contributes significantly to the high morbidity and mortality in the BPD patients. Therefore, regular monitoring for PH by using echocardiography and B-type...
- Case Report
- A case of hippocampal sclerosis diagnosed as cortical dysplasia due to preoperative brain MRI finding
- Jun Seok Lee, Kyo Ryung Kim, Jeong Tae Kim, Min Jung Choi, Young Mock Lee, Heung Dong Kim, Joon Soo Lee, Dong Seok Kim, Tae Seong Kim
- Clin Exp Pediatr. 2010;53(1):106-110. Published online January 15, 2010
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Hippocampal sclerosis (HS) is one of the most common features of intractable temporal lobe epilepsy. Generally it can be identified through brain magnetic resonance imaging (MRI) with high degree of sensitivity and specificity. Typical brain MRI findings of HS are hippocampal atrophy with hyperintense signal confined to the lesion. On the other hand cortical dysplasia exhibits blurring of the gray-white... -
- Original Article
- The effects of neonatal ventilator care or maternal chorioamnionitis on the development of bronchopulmonary dysplasia
- Ki Tae Yun, Whan Dong Lee, Sang Geel Lee
- Clin Exp Pediatr. 2009;52(8):893-897. Published online August 15, 2009
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Purpose:Advances in neonatal intensive care have improved the survival rate of low-birth-weight infants, but mild bronchopulmonary dysplasia (BPD) with the accompanying need for prolonged oxygen supplement remains problematic. Maternal chorioamnionitis and neonatal ventilator care affect the development of BPD. This study aimed to examine whether maternal chorioamnionitis or neonatal ventilator care affect the development of BPD dependently or independently. Methods:We performed a retrospective study... -
- Montelukast as an add-on therapy in bronchopulmonary dysplasia
- He Min Kim, Ji Eun Song, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2009;52(2):181-186. Published online February 15, 2009
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Purpose : Inflammation plays a potential role in the pathogenesis of bronchopulmonary dysplasia (BPD). Strategies for preventing BPD include respiratory management, antioxidants, nutritional treatment, and others such as anti-inflammatory agents. We aimed to assess the safety, tolerability, and efficacy of montelukast (MK), a cysteinyl leukotriene 1 receptor antagonist, as an add-on therapy in BPD. Methods : In addition to currently available... -
- The effects of early surfactant treatment and minimal ventilation on prevention of bronchopulmonary dysplasia in respiratory distress syndrome
- Jong Jin Park, Pil Sang Lee, Sang Geel Lee
- Clin Exp Pediatr. 2009;52(1):44-49. Published online January 15, 2009
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Purpose : Early surfactant treatment and minimal ventilation, bronchopulmonary dysplasia needed prolonged oxygen supplement is a problem. This study aimed to report the effects of early surfactant treatment and minimal ventilation on the prevention of bronchopulmonary dysplasia in respiratory distress syndrome. Methods : We retrospectively studied 139 premature newborn infants (gestational age, 36 weeks; birth weight, 1,500 gm) admitted to... -
- Review Article
- Recent progress in the understanding of clinical characteristics, epidemiology, and pathogenesis of new bronchopulmonary dysplasia
- Beyong Il Kim
- Clin Exp Pediatr. 2009;52(1):6-13. Published online January 15, 2009
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Recent advances in perinatal care have resulted in improved survival of extremely low birth weight infants (ELBWI). However, bronchopulmonary dysplasia (BPD) remains one of the major complications in ELBWI. BPD was originally described over 40 years ago; the clinical characteristics, epidemiology, and pathogenesis of BPD have changed markedly through this period. In this article, I have reviewed recent progress in... -
- Original Article
- The effect of restricted fluid intakes in the first week of life on the risk of bronchopulmonary dysplasia and patent ductus arteriosus in very low birth weight infants
- Hoe Kyoung Koo, Eun Na Choi, Ran Namgung, Min Soo Park, Kook In Park, Chul Lee
- Clin Exp Pediatr. 2007;50(6):536-542. Published online June 15, 2007
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Purpose : We investigated the effects of restricted fluid in the first 7 days of life on the risk of bronchopulmonary dysplasia (BPD) or patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants. Methods : Eighty three VLBW infants who lived more than 28 days were selected. The amount of daily maintenance fluid was determined by calculation of insensible... -
- Case Report
- A case of restrictive dermopathy
- Seung Ik Lee, Chang Hee Hong, Yun Ha Cheong, Mi Seon Kang, Jong Beom Sin
- Clin Exp Pediatr. 2007;50(3):306-310. Published online March 15, 2007
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Restrictive dermopathy is a rare autosomal recessive disorder in which rigidity or tautness of the skin from the second trimester causes a fetal akinesia deformation sequence (FADS) and early death. Characteristic features include taut skin with prominent subcutaneous vessels, widely open fontanelles and cranial sutures, distinctive facies, flexion contractures, pulmonary hypoplasia, sparse eyelashes and and eyebrows, thin dysplastic clavicles. The... -
- Original Article
- High-resolution computed tomography findings of lung parenchyme changes in very low birth weight infants treated with oxygen
- Young Man Jin, David Chanwook Chung, Young Pyo Chang, Yung Suk Lee, En Sun Lee
- Clin Exp Pediatr. 2007;50(3):255-261. Published online March 15, 2007
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Purpose : The objective of this study is to observe high-resolution computed tomography (HRCT) findings of lung parenchyme in very low birth weight (VLBW) infants between the corrected age of 38-42 weeks who were treated with oxygen after birth, and to compare them to the clinical severity of bronchopulmonary dysplasia (BPD). Methods : The lungs of fourty-four VLBW infants with gestational... -
- Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
- Jee Yoon Park,, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye sook Park, Eun Hee Ha, Eun Ae Park
- Clin Exp Pediatr. 2007;50(3):248-254. Published online March 15, 2007
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Purpose : Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood of preterm newborns with RDS or BPD. Methods : Forty preterm newborns whose mothers received antenatal care at Ewha Womans University Mokdong Hospital between January 2003 to June 2005, and... -
- The efficacy of ketogenic diet in childhood intractable epilepsy with malformation of cortical development
- Young-Mock Lee, Du Cheol Kang, Da Eun Chung, Hoon Chul Kang, Heung Dong Kim
- Clin Exp Pediatr. 2006;49(2):192-197. Published online February 15, 2006
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Purpose : Malformation of cortical development(MCD) constitutes an important etiology of intractable epilepsy and is considered an indication for surgical treatments, though their efficacy is limited and variable depending on MCD's location or distribution. Ketogenic diets are widely known to be effective, but as little study has been made concerning their efficacy on epilepsy with MCD, we evaluated the efficacy... -
- Medical Lecture Course
- Factors Involved in Lung Development and Alveolarization
- Min Soo Park
- Clin Exp Pediatr. 2004;47(10):1031-1035. Published online October 15, 2004
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Lung development is a sum of processes that involve harmonized orchestration of expressions of various factors in time and space. The mastermind governing these phenomena is not known, but cumulative efforts so far have helped us gain some insights as to what are involved in and how complex the developmental process is. Beginning as primitive foregut, lungs undergo processes called... -
- Case Report
- A Case of Rhizomelic Chondrodysplasia Punctata Occurring in Siblings
- Soon Hwa Yoon, Nam Young Kim, Seon Hee Shin, Sung Koo Kim, Kon Hee Lee, Hae Sun Yoon, Jung Eun Kim
- Clin Exp Pediatr. 2004;47(9):1016-1019. Published online September 15, 2004
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Chondrodysplasia punctata is a group of heterogeneous bone dysplasia characterized by punctate calcifications of the cartilage, frequently associated with a shortening of the limbs, cataracts, icthyosis and alopecia, alterations of the nervous system, and mental and growth deficiencies. Our case presented findings of the rhizomelic chodrodysplasia punctata : a characteristic face, a sucking difficulty and a short neck. Skeletal radiographies... -
- Original Article
- The Effect of Post-natal Weight Changes on the Development of Bronchopulmonary Dysplasia in Infants with Respiratory Distress Syndrome
- Hye One Jhon, Young Min Kim, Hee Joo Hong, Chong Woo Bae
- Clin Exp Pediatr. 2004;47(3):269-274. Published online March 15, 2004
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Purpose : The subjects were compared and measured for differences in the aspects of weight changes between the groups that developed bronchopulmonary dysplasia(BPD) after treatment and those that did not, to analyze the relations between the patterns of early weight change after birth and the development of BPD. Methods : Retrospective analysis of medical records were performed for birth weight and... -
- Case Report
- A Case of Craniofrontonasal Dysplasia Diagnosed at Birth
- Jeong A Rho, Young Il Rho, Kyung Rye Moon, Young Bong Park, Sang Kee Park, Eun Young Kim
- Clin Exp Pediatr. 2003;46(10):1044-1046. Published online October 15, 2003
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Craniofrontonasal dysplasia(CFND), a rare congenital syndrome, is characterized by varying degrees of frontonasal dysplasia, craniosynostosis, and variable extracranial abnormalities. It was first reported by Cohen in 1979. The inheritance pattern is not straightforward. Although all modes of Mendelian inheritance have been suggested, the most plausible explanation is that this is an X-linked condition with the unusual situation of complete expression... -
- A Case of Rhizomelic Chondrodysplasia Punctata Type I
- Dal Hyun Kim, Young Se Kwon, Yong Hoon Jun, Young Jin Hong, Byoung Kwan Son, Hye Ran Yoon
- Clin Exp Pediatr. 2002;45(12):1585-1590. Published online December 15, 2002
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Rhizomelic chondrodysplasia punctata(RCDP) is a rare autosomal recessive disorder clinically characterized by symmetrical shortening of the proximal limbs, contractures of joints, a typical dysmorphic face, cataracts, and itchyosis. Patients with RCDP can be subdivided into three subgroups based on biochemical analysis and complementation studies. RCDP type I results from mutations in the PEX7 gene encoding the peroxisomal targeting signal type... -
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6.52022CiteScore92nd percentilePowered by
