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Original Article
Neurology
Prognostic factors of neurological outcomes in late-preterm and term infants with perinatal asphyxia
Sun Young Seo, Gyu Hong Shim, Myoung Jae Chey, Su Jeong You
Clin Exp Pediatr. 2016;59(11):440-445.   Published online November 18, 2016
Purpose

This study aimed to identify prognostic factors of neurological outcomes, including developmental delay, cerebral palsy and epilepsy in late-preterm and term infants with perinatal asphyxia.

Methods

All late-preterm and term infants with perinatal asphyxia or hypoxic-ischemic insults who admitted the neonatal intensive care unit of Inje University Sanggye Paik Hospital between 2006 and 2014 and were followed up for at least 2...

The Significance of the Early Electroencephalographic Findings in Severely Asphyxiated Newborn Infants
Jong Uk Lee, Won Joung Choi, Chun Soo Kim, Sang Lak Lee, Jun Sik Kim
Clin Exp Pediatr. 2003;46(8):784-788.   Published online August 15, 2003
Purpose : Perinatal asphyxia occurring in newborn is one of the major causes of acute mortality and chronic neurological disability in survivors. We have studied the relationship between early electroencephalography(EEG) findings and clinical course and neurologic outcome in severe asphyxiated neonates. Methods : Between the period of July 1999 and June 2002, 25 neonates who were diagnosed with severe perinatal asphyxia(1-minute...
Evoked Potentials and Cranial Ultrasonography as a Prognostic Method in Newborn with Asphyxia
Hyung Jin Kim, Hee Kang, Byoung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2001;44(10):1162-1167.   Published online October 15, 2001
Purpose : This study was aimed at finding a diagnostic tool which is useful in predicting the neurologic outcome of the asphyxiated newborns. Methods : 31 newborns with asphyxia were evaluated by brainstem evoked potentials and cranial ultrasonography(CUS). During the neonatal follow-up, we evaluated the development of the babies with Bayley Scale of Infant Development II and INFANIB on corrected age...
The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -
Seon Mi Park, Eun Young Kim, Yeong Bong Park, Sang Kee Park
Clin Exp Pediatr. 2001;44(10):1119-1126.   Published online October 15, 2001
Purpose : Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord...
Clinical Efficiency of Cardiac Troponin T for Myocardial Damage in Neonatal Asphyxia
Nam Soo Kang, Jae Kyun Yoon, Chang Sung Son, Joo Won Lee, Young Chang Tokgo, Sang Hee Kim
Clin Exp Pediatr. 1999;42(2):195-202.   Published online February 15, 1999
Purpose : The aim of this study was to evaluate the clinical efficiency of cardiac troponin T (cTnT) in detecting myocardial damage in neonatal asphyxia and to compare the diagnostic value of cTnT with creatine kinase MB(CK-MB). Methods : Sixty-three neonates were enrolled in this study, consisting of 27 asphyxiated infants (asphyxiated group; 1-min or 5-min Apgar score≤6) and 36 healthy...
The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates
Seung Yeon Nam, Eun Ae Par, Seung Joo Lee
Clin Exp Pediatr. 1998;41(12):1685-1692.   Published online December 15, 1998
Purpose : Low-dose dopamine(0.5-3μg/kg/min) increases renal blood flow, glomerular filtration rate and natriuresis and has protective and therapeutic effects on oliguric renal failures. Asphyxia is the most common cause of acute renal failure in neonates. But the protective effects of dopamine have never been reported in asphyxiated neonates. So we reported the effects of low-dose dopamine on the renal function...
Delayed Cerebral Energy Failure After Acute Hypoxia-Ischemia in Neworn Piglet Under 48hours of Continuous Monitoring Using Near-Infrared Spectroscopy
Yun Sil Chang, Won Soon Park, Munhyang Lee, Ki-Soo Kim, Jung-Hwan Choi, Son Moon Shin
Clin Exp Pediatr. 1998;41(9):1198-1210.   Published online September 15, 1998
Purpose : To test the hemodynamic and biochemical sequences of secondary cerebral energy failure after acute reversed hypoxic ischemic brain insult(HI) can be reproduced in newborn piglets. Methods : Fifteen anesthetized, ventilated newborn piglet(<3 day) were studied. Eight(HI) were induced transient HI by breathing 8% oxygen and complete occlusion of bilateral common carotid arteries for 30 minutes followed by reoxygenation...
On the Significance of Blood Sampling Time in Neonatal Neurologic Prognosis Using Creatine Kinase BB
Heung Taek Kim, Mi Kyung Son, Eun Ju Kim, Kyuchul Choeh
Clin Exp Pediatr. 1998;41(5):669-676.   Published online May 15, 1998
Purpose : To investigate the cut-off value of creatine kinase(CK) BB according to blood sampling time in predicting neonatal prognosis, we studied the time-related releasing pattern of CK isoenzymes after birth asphyxia. Methods : CK was measured within 1 hour and at 6-10 hours after birth from 45 newborn infants who were suspected to be perinatal asphyxia or fetal distress. The...
Significance of Creatine Kinase Isoenzymes for Neurologic Outcome in Perinatal Asphyxia
Mi Kyung Son, Eun Sik Kang, Sun Hi Jung, Kyuchul Choeh
Clin Exp Pediatr. 1996;39(7):924-933.   Published online July 15, 1996
Purpose : To investigate the usefulness of the serum Creatine kinase(CK), especially brain typical creatine kinase(CK-BB) as an indicator of brain damage extent, mortality and long term nurologic sequelae, the study was done. Methods : CK and CK isoenzyme activites were measured at 6-10 hours after birth in 160 asphyxiated newborn infants who admitted in Eulji General Hospital from August 1990 to July 1994. Infants...
Auditory Evoked Potentials in Fullterm Infants with Birth Asphyxia and Premature Infants
Ha Shin Park, Myung Suk Song, Sun Jun Kim, Hea Jin Choeh, Kyu Chul Choeh
Clin Exp Pediatr. 1995;38(8):1054-1060.   Published online August 15, 1995
Purpose : Auditory evoked potentials(AEP) are sensitive electrophysiological technique which accurately assesses the functional integrity of the auditory pathway in the brainstem. As a test of brainstem function, AEP have the advantages that the procedure is standardized, the results are reproducible, the norms for neonated have been estsblished, and the equipment to perform the test is widely available. Our study...
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(9):1196-1204.   Published online September 15, 1994
Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)...
Effect of Perinatal Asphyxia and Gentamicin on Urinary β2-microglobulin Concentration and Renal Function in Fullterm Neonates
Hoo Jae Hann, Seung Joo Lee
Clin Exp Pediatr. 1994;37(7):976-985.   Published online July 15, 1994
Perinatal asphyxia can cause ischemic injury to immature kidney of neonates. Proximal renal tubule is the most sensitive area, showing various manifestations ranging from mild reversible injury to irreversible tubular necrosis. Aminoglycosides can be nephrotoxic in therapeutic range in immature or damaged kidney. These are the very important factors to be taken into corsideration on fluid therapy and nephrotoxic drugs...
Prediction of Neurologic Outcome of Perinatal Asphyxia by Use of CK-BB Isoenzyme Measurements
Eun Sik Kang, Jung Hea Park, Hea Jin Choeh, Chong Sung Chung, Kyuchul Choeh
Clin Exp Pediatr. 1994;37(1):19-25.   Published online January 15, 1994
Creatine kinase (CK) isoenzyme are considered as a specific tissue injury marker. Brain tyupe isoenzyme of CK (CK-BB) was measured in 44 healthy and 33 asphyxiated preterm and fullterm infants. Samples were drawn from peripheral blood at six to ten hours after birth. There were no difference of CK-BB and CK-BB% between preterm and fullterm infants. CK-BB and CK-BB% were well...
The Significance of Nucleated Red Blood Cell Counts in Low Birth Weight Neonates
In Ho Song, Weon Kee Lee, Hye Lim Jung, Dong Hyuck Keum
Clin Exp Pediatr. 1993;36(11):1526-1533.   Published online November 15, 1993
We studied to assess the relationship between intrauterine growth retardation and the increased nucleated red blood cell counts (NRBC) in small for gestational age (SGA) and appropriate for gestational age (AGA) neonates with low birth weight. We also evaluated the nucleated red blood cell counts in low birth weight neonates who had either perinatal asphyxia or hyaline membrane disease (HMD)...
Plasma Immunoreactive Endothlin-1, Creatine Kinase and CK Isoenzyme and Its Relation to Neonate with-Asphyxia
Kang Woo Lee, Kee Hyoung Lee, Chang Sung Son, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(10):1434-1440.   Published online October 15, 1993
Endotheline-1(ET-1) is a potent vasoconstrictor peptide with 21 amino acid residues. ET-1 is thought to have a key role in vasoconstriction, and cardiac, renal, and endocrine actions of the peptide. Creatine Kinase(CK), also referred to as ATP-creatine-N-phosphotransferase, consists of either the B or M type. CK is found almost exclusively in muscle (MM), myocardium (MB), and brain (BB). It is...
Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns
Ki Young Koo, Nam Geun Heo, Heng Mi Kim
Clin Exp Pediatr. 1993;36(9):1219-1226.   Published online September 15, 1993
This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK)and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5%...
A Study of Serum and Spinal Fluid Enzyme Such as CPK and LDH as Predictors of Neurologic Disability Following Perinatal Asphyxia
Min Hye Kim, Hye Jin Lee, Gyoung Hee Kim
Clin Exp Pediatr. 1993;36(5):664-670.   Published online May 15, 1993
Perinatal asphyxia is an insult to fetus or newborn due to lack of oxygen or perfusion to various organsm especially to brain, resulting in the important complication known as hypoxic inchemic encephalopathy. A clinical study was conducted on 30 newborns with perinatal asphyxia, who were admitted to Pediatric department of Ewha Women's University Hospital during 19 months period from Sep. 1990...
A Study of Serum CK-BB Activity as a Diagnostic Method and a Predictor of Neurologic Out come in Asphyxiated Infants
Clin Exp Pediatr. 1993;36(3):371-378.   Published online March 15, 1993
Asphyxia is the most important perinatal cause of neurologic morbidity in infants. Recently, elevated levels of CK-BB have been demonstrated in serum after asphyxic insult in infants. To evaluate the possibility of using serial measurements of CK-BB activity as a diagnostic method and a predictor of neurologic outcome in asphyxiatic infants. We studied CK-BB activity in serum of asphyxiated infants(16...
Case Report
A Case of Asphyxiating Thoracic Dystrophy Type II
Sang Mi Ha, Soon Il Lee, Moon Chul Kim, Je Geun Chi
Clin Exp Pediatr. 1992;35(12):1756-1761.   Published online December 15, 1992
Asphyxiating thoracic dystrophy (ATD) is a rare inherited malformation first described in 1954 by Jeune et al. ATD is a clinical and radiological entity characterized by disturbance of in utero endochondral bone formation; it appears with a small thoracic cage and pelvic and phalangeal abnormalities. The authors experienced a case of ATD in a 1 day old boy with the chief...
Original Article
The Significance of Nucleated Red Blood Cell Counts in Various Conditions Associated with Acute or Chronic Perinatal Asphyxia
Suck Kyu Hur, Moon Sang Park, Mee Kyung Namgoong, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim, Myung Seo Kang
Clin Exp Pediatr. 1992;35(11):1514-1519.   Published online November 15, 1992
This study was conducted to find out the significance of nucleated red blood cell (NRBC) in neonates, especially associated with acute or chronic perinatal asphyxia. So, we compared NRBC counts in various neonatal groups, such as normal newborn, small for gestational age (SGA), premature, acute perinatal asphyxia, & hyaline membrane disease (HMD). In the first day of life, we examined...
A Study of Auditoru Brainstem Responses in Neonates with Birth Asphyxia
Su Kyung Kang, Kum Hee Hur, Myoung Jae Chey, Hak Soo Lee, Il Tae Kang
Clin Exp Pediatr. 1992;35(2):191-200.   Published online February 15, 1992
Birth asphyxia is an insult to fetus or newborn due to lack of oxygen or perfusion to various organs, especially to brain, resulting in the important complication known as hypoxic ischemic encephalopathy. Auditory brainstem responses may assist in evaluating the severity of the brain injury. ABR testing was performed in 20 ful term neonates with birth asphyxia with 1-minute or 5-minute...
A case of asphyxisting thoracic dystrophy.
Chang Hee Bae, Jong Min Lee, In Hee Park, Chin Sam Ro, Hyo Jin Lee
Clin Exp Pediatr. 1991;34(6):832-836.   Published online June 30, 1991
We experienced a case of asphyxiating thoracic dystrophy in one day old female with a chief complaint of respiratory difficulty, cyanosis, small thoracic cage and polydactyly. The diagnosis was made on the basis of typical morphologic feature, radiologic finding and autopsy finding. A brief review of the related literature was made.
A clinical study on influences of premature rupture of membranes in the newborn infant.
Ji Sun Cho, Young Sun Ko, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1991;34(2):180-189.   Published online February 28, 1991
A clinical study was made on 607 newborns of mothers with premature rupture of membrane (PROM group) and 5,775 newborns of mothers without ruptured membrane Baptist Hospital from January 1987 to December 1989. The results are summarized as follows: 1) The overall incidence of PROM was 9.5% with little yearly variations. 2) 11.9% of all babies with PROM were bom prematurely, significantly higher than the incidence of control...
A case of Asphyxiating Thoracic Dystrophy.
Hyung Goo Cho, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim, Whi Yul Cho, So Young Jin
Clin Exp Pediatr. 1990;33(9):1294-1300.   Published online September 30, 1990
Asphyxiating thoracic dystrophy, a rare form of bony dysplasia, is characterized by extreme constriction of thorax, short limbed dwarfism, abnormalities of pelvic bone in neonatal period, and progressive interstitial nephritis in childhood. The incidence of this syndrome has been estimated at 1 per 100,000 to 130,000 live births and more than 100 patients have been reported worldwide. Infants with asphyxiating thoracic dystrophy usually have...
Change of Auditory Brainstem Response(ABR) on Neonatal Asphyxia.
Jeong Sam Jeon, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1989;32(10):1391-1396.   Published online October 31, 1989
Neonatal asphyxia is insult to the newborn due to lack of oxygen or perfusion to various organs. It is associated with tissue hypoxia, especially brain. So hypoxic-ischemic brain injury is the most important complication known as hypoxic-ischemic encephalopathy. The EEG as well as various evoked potentials (auditory, visual and somatosensory) may assist in evaluating the severity of the damage. This study was undertaken to...
Influences of Premature Rupture of Membranes on the Newborn Infant.
Kyoung Sim Kim, Young Ok Park, In Sung Lee, Ki Bok Kim
Clin Exp Pediatr. 1989;32(2):149-157.   Published online February 28, 1989
A comparative study on the frequencies of premature birth, neonatal sepsis, asphyxia, perinatal death and respiratory distress syndrome was carried out between 1309 newborns with premature rupture of membranes (PROM) and the normal group of 4636 newborns without PROM among all 5945 babies delivered at Kwangju Christian Hospital for the 2-year period starting from March 1985. The results are sumrnarized as follows: 1) The overall...
A Prospective Study ot Neonatal Acute Renal Failure: The Significance of Various Diagnostic Indices.
Kyung Hyo Kim, Seung Joo Lee, Keun Lee
Clin Exp Pediatr. 1987;30(4):378-384.   Published online April 30, 1987
Acute renal failure is defined as a sudden decrease in renal function resulting in progressive retention of nitrogenous waste products. Acute renal failure should be suspected in any infant who has a sustained decrease in urine output to less than 1 ml per kg per hour, a blood urea nitrogen level above 20 mg per dl, a serum creatinine level greater than 1.0...
Progostic Factors in Neonatal Asphyxia.
Hye Li Chung, Wan Sup Kwak, Haeng Mi Kim, Doo Hong Ahn
Clin Exp Pediatr. 1986;29(4):420-425.   Published online April 30, 1986
A clinical study was conducted on 30 term babies with neonatal asphyxia, who were admitted to Pediatric Department of Kyungpook National University Hospital during 2years period from May 1983 to April 1985. Of the 20 cases returned to follow up, 15 cases were neurodevelopmentally normal but 5 cases were retarded with neurologic disability. Retarded case revealed higher incidence of severe asphyxia...
Associated Ventilation with Mechanical Aids in Newborn Infants.
Eue Cho Yang, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1985;28(5):435-447.   Published online May 31, 1985
Clinical features of 85 neonates who treated with assisted ventilation in Neonatal Intensive Care Unit at Seoul National University Hospital from April ’80 to Dec. 5 84 were analyzed with special respect to mechanical aids. The results were as follows; 1)According to diagnostic categories, 56 cases (66%) were hyaline membrane disease (HMD), 14 cases (16%) were postasphyxia syndrome (PAS), 9 cases...
Case Report
A case of asphyxiating thoracic dystrophy.
Young Joo Suh, Seung Ki Kim, Soon Ok Byun, Ji Sub Oh, Ok Ji Paik
Clin Exp Pediatr. 1985;28(2):177-181.   Published online February 28, 1985
We have experienced a case of Asphyxiating thoracic dystrophy in 22 hour old boy who had constriction of thorax and short extremities. The diagnosis was confirmed by clinical features, radiological and autoptic finding. A brief review of the related literatures was also made.
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