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Original Article
A Study on Clinical Characteristics of Maxillary Sinusitis in Korean Children
Dong Nam Kim, Sung Hee Oh, Hahng Lee
Clin Exp Pediatr. 1995;38(3):319-327.   Published online March 15, 1995
Purpose : Paranasal sinusitis, easily overlooked owing to it's benign symptomatology, should be considered when the upper respiratory tract infction persists longer than seven days. Without early recognition and appropriate management, the disease will take a chronic course and the incidence of complications will be increased. The significance of paranasal sinusitis among Korean children has not appropriately been appreciated; therefore,...
Case Report
Two Cases of Rupture of the Sinuses of Valsalva
Jina Son, Young Jin Hong, Don Hee Ahn
Clin Exp Pediatr. 1995;38(1):117-121.   Published online January 15, 1995
Rupture of the sinuses of Valsalva is not common in childhood. It is frequently associated with other heart disease, most commonly with VSD. It is classified into four types, anatomically. The symptoms are differentiated as acute, gradual progression, and unruptured aneurysm. We experienced 2 cases of rupture of the sinuses of Valsala, which were corrected completely after operation. The patients were 14 year old...
A Case of Dandy-Walker Syndrome with Complex Cardiac Anomaly
Ssack Joong Yoon, Sung Jin Hong, Hyung Goo Cho, Dong Chul Park
Clin Exp Pediatr. 1995;38(1):110-116.   Published online January 15, 1995
The Dandy-Walker syndrome is a developmental disorder of the brain characterized by cystic dilatation of the fourth ventricle and agenesis or hypoplasia of the cerebellar vermis. We experinced a case of Dandy-Walker syndrome with complex cardiac anomaly in female newborn who presented with apnea at birth. Physical examination showed coloboma on left eye, low estting malformed ear, and high arched...
Original Article
Cystic Kidney Disease According to Potter's Classification
Kee Hyuck Kim, Sung Chul Shin, Soon Il Lee, Je Geun Chi
Clin Exp Pediatr. 1995;38(1):91-98.   Published online January 15, 1995
The cystic disease of the kidney include a heterogeneous group of developmental, hereditary, and acquired disorders. Based on extensive microdissection studies, Potter concluded all renal cystic diseases could be categorized into four types. We have experienced 5 cases of cystic kidney disease which were confirmed by aoutopsy and classified as Type I, Type II, Type III, Boderline between types II and...
A Study on Prognostic Factors in Children with Encephalopathy
Jin Nyoung Park, In Joon Seol
Clin Exp Pediatr. 1994;37(12):1738-1745.   Published online December 15, 1994
To elucidate the clinical characteristics-especially its clinical pattern and outcome of chidren with encephalopathy, we carried out a retrospective review on medical records of 45 patients who were intially diagnosed as encephalopathy except mumps meningitis, Reye's syndome and neonatal hypoxic ischemic encephalopathy at the Department of pediatrics, Hanyang University children's hospital from January 1986 to February 1994. The results were summerized...
The Variations of CSF Glucose-To-Blood Glucose Ratio according to the Time of Blood Sampling in Asepetic Meningitis
Dong Gui Jang, Yong Seok Choi, Mee Kyoung Lee, Chang Hee Kim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1687-1692.   Published online December 15, 1994
The Measurement of CSF glucose and CSF glucose-to-blood glucose ratio is a very useful laboratory test for the differential diagnosis of meningitis. We have observed the change of blood glucose & CSF glucose-to-blood glucose ratio according to the time of blood sampling in 84 patients with aseptic meningitis who had been admitted to the department of peditrics, Dong Kang hospital...
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
A Clinical Study on Urinary Tract Infection in Infants and Children
Yoon Hwa Cha, Hee Ran Choi, Seong Hee Jang, Young Min Ahn
Clin Exp Pediatr. 1994;37(11):1488-1499.   Published online November 15, 1994
This is a report of clinical study on the 63 patients of symptomatic urinary tract infection who were hospitalized at the Department of Pediatrics in Kangnam General Hospital during the period between the May of 1989 and the September of 1992. The observation results were as follows: 1) The frequency of urinary tract infection (UTI) was the highest in children...
Clinical and Epidemic Studies of Aseptic Meningitis
Dong Yoon Kim, Koo Pong Jung, Heung Keun Oh, Chang Ok Soh, Jin Young Jung
Clin Exp Pediatr. 1994;37(10):1420-1426.   Published online October 15, 1994
Case Report
A Case of Cerebral Infarcion due to Thrombosis Associated with Focal Segmental Glomerulosclerosis and Steroid Resistant Nephrotic Syndrome
Dae Woo Kim, Heon Lang Park, Sang Man Shin, Eun Mi Kim
Clin Exp Pediatr. 1994;37(9):1317-1324.   Published online September 15, 1994
Focal segmental glomerulosclerosis is the renal histopathologic lesion observed in 10% of children with idopathic nephrotic syndrome. Complications include infection, thrombosis, hypocalcemia and adverse effect of steroid use. The incidnce of thrombosis reported ranges from 10~40%. The pathogenesis are changes in coagulation system, decrease of Antithrombin III, increase platelet aggregability and steroid or diuretics use. These changes take place passively...
A Case of Congenital T Cell Lymphoblastic Lymphoma
Eun Sun Yoo, Young Mi Hong, Kyung Hee Kim, Hae Soo Gyu, Eun Chul Chung
Clin Exp Pediatr. 1994;37(9):1296-1304.   Published online September 15, 1994
T cell lymphoblastic lymphoma is characterized by immature lymphoid cells that are indistinguishable from the lymphoblasts and prolymphocytes of acute lymphoblastic leukemia. Several characteristic clinical features of lymphoblastic lymphoma, with include a high male-to-female ratio, a relatively high incidence in older children and young adults, the frequent presence of mediastinal involvement at the time of diagnosis. Also, this disease is...
Isolated Angiitis of the Central Nervous System
Seon Jin Ji, Jin Young Choi, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim, Myung Soon Kim
Clin Exp Pediatr. 1994;37(9):1286-1291.   Published online September 15, 1994
Isolated angiitis of the central nervous system is a rare clinicopathologic entity characterized by vasculitis restricted to the vessels of the central nervous system without other apparent systemic vasculitis. It manifests headache, higher cortical dysfunction, focal neurologic dysfunction and cranial nerve palsies. We experienced a case of isolated angiitis of the central nervous system in 6 year-old girl who was admitted...
Familial Hemophagocytic Lymphohistiocytosis
Dong Un Kim, Dae Kyun Koh, Yeon Dong Lee, Jae Kyun Hur, Kyoo Hong Cho, Suk Jin Kang
Clin Exp Pediatr. 1994;37(9):1279-1285.   Published online September 15, 1994
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease characterized by fever, hepatosplenomegaly, cytopenia and non-malignant lymphohistiocytic infiltration with hemophagocytosis in reticuloendothelial organs. We experienced three cases of FHL in identical male twins and their younger brother who presented with fever and severe hepatosplenomegaly. Cytompenia, elevated serum transaminase and low serum albumin levels, hypertriglyceridemia were common laboratory findings of them. One of...
Original Article
The Roles of IgG and Albumin as a Predictor of Frequent Relapse
Jae-Ho Lee, Jong-Gyun Kim
Clin Exp Pediatr. 1994;37(9):1245-1250.   Published online September 15, 1994
The etiology of nephrotic syndrome is unknown. The characterization were proteinuria, hypoalbuminemia, generalized edema and hyperlipidemia. To assess the recurrence factors in the nephrotic syncrome, we measured serum immunoglobulin(IgG, IgA, IgM), albumin, complement, cholesterol and the 24-hour total urine protein at the initial relapse of nephrotic syndrome. Each data of frequent and infrequent relapsed nephrotic syndrome were compared. In total...
Detection of Enterovirus in Patients with Aseptic Meningitis by Reverse Transcription and Polymerase Chain Reaction
Souck Joong Yoon, Sung Jin Hong, Young Hyuk Lee, Min Hee Kim, Kyo Sun Kim, Kyu Hyun Park, Jae Myun Lee, Won Young Lee
Clin Exp Pediatr. 1994;37(9):1226-1234.   Published online September 15, 1994
The aim of this study was to determine the applicability of reverse transcription and polymerase chain reaction(RT/PCR) for routine diagnostic use and for the detection of enteroviral mentigitis, Primers were selected in the highly conserved part of the 5'-non-coding region of the enteroviral genome. Enteroviral RNA was detected by the RT/PCR in routinely collected cerebrospinal fluids(CSF) of patients with aseptic...
Case Report
One Case of Maffucco's Syndrome with Testicular Teratoma
Seung Mo Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1994;37(8):1162-1168.   Published online August 15, 1994
Maffucci's syndrome is a very rare, congenital and non-hereditary mesodermal dysplasia manifested by multiple enchondromas and soft tissue hemangiomas. Since Maffucci had reported this syndrome in 1881, there have been more than 100 cases reported, and also there has been reported that Maffuddi's syndrome has various interstitial tumor. However there hasn't been any report about Maffucci's syndrome with testicular teratoma....
Original Article
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Case Report
A Case of Steven-Johnson Syndrome Associated with Cholestatic Hepatitis
Tae-Hee Park, Ran-Ju Kim, Byoung-Geun Lee, Soo-Chul Cho, Dae-Yeol Lee
Clin Exp Pediatr. 1994;37(7):1016-1019.   Published online July 15, 1994
A12-year-old boy developed cholestatic hepatitis with Steven-Johnson syndrome following the use of amoxicillin. The skin lesion and general condition were improved over 2 weeks, but jaundice was gradually aggrevated. We performed liver biopsy, on 30th hospital day, which showed cholestatic hepatitis. The patient improved gradually and liver function was normalized 5 months later.
A Case of Pulmonary Blastoma
Yun Jeong Chang, Jeong Hee Kim, Sun Ki Kim, Byong Kwan Son, Joon Mi Kim, Young Chae Chu
Clin Exp Pediatr. 1994;37(7):999-1005.   Published online July 15, 1994
Pulmonary blastoma is a rare type of malignant lung tumor comprised of epithelial and mesenchymal elements reminiscent of fetal lung. Mesenchymal element may show various patterns of differentiation toward mature tissue, such as cartilage, smooth muscle, and bone. Rhabdomyoblastic differentiation in pulmonary blastoma is quite rare. Our case of pulmonary blastoma with rhabdomyoblastic differentiation documented by electron microscopy and immunohistochemistry. Usually...
A Case of Cerebral Infarction and Subdural Hemorrhage after Aseptic Meningitis
Hyun Mi Kim, Si Whan Koh, Kyung Hwan Oh, Young Chang Kim, Sang Joo Lee
Clin Exp Pediatr. 1994;37(5):707-711.   Published online May 15, 1994
After aseptic or septic meningitis, some neurologic complications such as convulsions, delirium, rigidity, cerebral infarctions and cerebral hemorrhage can be developed. The cerebral infarction after meningitis is caused by arterial or venous occlusions. Involvement of small perforating arteries leads to ganglionic infarcts while severe sapsm of major vessels may lead to massive infarctions in the distribution of middle and/or anterior...
A Case of Brain Damage in Surviving Monozygotic Twin After Intrauterine Death of Co-Twin
Jae Young Choi, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Tae Sub Chung
Clin Exp Pediatr. 1994;37(5):701-706.   Published online May 15, 1994
Various anatomical defects have been described in the surviving twin who had a stillborn, macerated monozygotic co-twin Disseminated Intravascular Coargulation. The etiology is thought to be placental transfer of emboli or thromboplastic material through placental vascular anastomoses. We experienced a case of monozygotic twin with deceased co-twin at 30 weeks of gestation and confirmed to have antenatal periventricular germinal matrix and...
Original Article
Occult Mediastinal Ganglioneuroblastoma Presenting with Myoclonic Encephalopathy as Paraneoplastic Syndrome
Hahng Lee, Dong Ki Han, Jae Won Oh, In Joon Seol, Eun Kyung Hong, Seok Chol Jeon
Clin Exp Pediatr. 1994;37(5):695-700.   Published online May 15, 1994
Ganglioneruroblastoma and neuroblastoma are among commonest types of childhood malignancy and a number of unique paraneoplastic syndromes have been associated with both localized and disseminated neuroblastoma. The coincidence of neuroblastoma and myoclonic encephalopathy or other paraneoplastic syndromes occurs relatively rare, and therefore, failure to recognize this association could result in delays in both diagnosis and treatment, and the result...
The Effect of Cranial Irradiation on Growth of Children with Lymphatic Origin Tumors
Jin Seoup Jung, Yon Sook Rho, Sang Woo Kim
Clin Exp Pediatr. 1994;37(5):666-671.   Published online May 15, 1994
A retrospective study was conducted to investigate the effects of CNS prophylaxis with 1,800cGy cranial irradiation on standing height growth of children with acute lymphoblastic leukemia(ALL). Seventeen longterm survivors (DFS over 5 years) of ALL and Non-Hodgkins Lymphoma who had been admitted at pediatric department of Inje University Seoul Paik Hospital from January 1982 to September 1988 were studied. The long term...
Evaluation of Pulmonary Venous, Mitral and Aortic Flow Pattern by Doppler Echocardiography in Neonates
Hye Soon Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1994;37(5):596-605.   Published online May 15, 1994
Pulmonary vein velocities have recently been estimated in conjunction with mitral flow velocities to increase our understanding of ventricular filling. The advent of transesophageal echocardiography with pulsed doppler imaging capability has provided a method by which both the mitral valve and pulmonary vein velocities can be easily recorded because of the posterior approach providing unimpeded interrogation of cardiac structures. The purpose...
Primary Cutaneous Aspergillosis in Leukemic Children
Jin Young Park, Mee Ran Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Guen Chi
Clin Exp Pediatr. 1994;37(4):520-526.   Published online April 15, 1994
Primary cutaneous aspergillosis is rare. In this report we describe primary skin infection by Aspergillus in 9 children with leukemia. The skin lesion was characterized clinically by erythematous macule and papule associated with pain and itching, followed by a rapid progression to ulcer and central black eschars with raised erythematous border at the site of venipuncture, insertion of intravenous cannula,...
Plasma Atrial Natriuretic Peptide Concentrations of the Pulmonary artery, Aorta and Veins in Children with Cardiac Disease
Kang Il Lee, Nam Geun Heo, Myung Chul Hyun, Sang Bum Lee, Eun Kyoung Yang, Won Jung Lee
Clin Exp Pediatr. 1994;37(4):481-493.   Published online April 15, 1994
To study the site of release and factors affecting the releases of the atrial natriuretic peptide (ANP) in the pediatric patients, we measured the plasma ANP concentrations in 23 normal healthy children, 19 patients with congestive heart failure and 16 patients with cardiac disease undergoing diagnostic cardiac catheterization. The following results were obtained. 1) The plasma ANP concentrations of the vein (226.3¡¾74.9...
Case Report
A Case of congenital Diverticulum of Ventricle Associated with Pulmonary Atresia
Kun Taek Kim, Jo Won Jung, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee
Clin Exp Pediatr. 1994;37(2):276-281.   Published online February 15, 1994
The congenital diverticulum of ventricle is a rare cardiac malformation arising from the left or right ventricle, the former being more common. Ventricular diverticulum is usually associated with other anomalies including intracardiac, midline thoracic, diaphragmatic and abdominal wall defect. The authors experienced a case of congenital diverticulum of left ventricle in nine month-old female infant. Left Blolock-Taussig shunt operation was done...
Original Article
The Significance of Bacteriologic Examination in the Childhood Tuberculosis
Kyung Bae Kwon, Jin Young Park, Bo Young Yoon, Mee Ran Kim, Hoan Jong Lee, Eui Jong Kim, Sang Jae Kim
Clin Exp Pediatr. 1994;37(2):221-230.   Published online February 15, 1994
We reviewed retrospectively the medical records of 229 cases of tuberculosis, who had been diagnosed clinically and admitted to the department of pediatrics, Seoul National University Children's Hospital, during the period of 6 years from October, 1985, to October, 1991. Patients with tuberculosis occupied 1.2%. of the hospitalized patients. Forty-three percent of the patients were under 3 years of age. Principal...
Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function
Jin Young Park, Ktung Bae Kwon, Mee Ran Kim, Hoan Jong Lee, Jin Q Kim, Wan Gyoon Shim, Kyoung Ho Park, Hae Lim Chung
Clin Exp Pediatr. 1994;37(2):185-192.   Published online February 15, 1994
We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum by method of Sawchuck. There was wide individual variation in peak serum concentrations of gentamicin and amikacin. Administration of the usually recommended doses yielded subtherapeutic concentration in 47% and 82%,...
Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
Clin Exp Pediatr. 1994;37(2):174-179.   Published online February 15, 1994
The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical...
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