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Review Article

Growth hormone treatment and risk of malignancy

Hyun-Wook Chae, Duk-Hee Kim, Ho-Seong Kim

Clin Exp Pediatr. 2015;58(2):41-46. Published online February 28, 2015

Growth hormone (GH) treatment has been increasingly widely used for children with GH deficiencies as the survival rate of pediatric patients with malignancies has increased. Both GH and insulin-like growth factor-I have mitogenic and antiapoptotic activity, prompting concern that GH treatment may be associated with tumor development. In this review, the authors examined the relationship between GH treatment and cancer...

DOI: https://doi.org/10.3345/kjp.2015.58.2.41

Original Article

Effects of growth hormone treatment on glucose metabolism in idiopathic short stature

Seung Yeon Kwon, Duk-Hee Kim, Ho-Seong Kim

Clin Exp Pediatr. 2006;49(6):665-671. Published online June 15, 2006

Purpose : To study the effects of growth hormone(GH) treatment on glucose metabolism and insulin resistance in children with idiopathic short stature(ISS). Methods : Glucose and insulin concentrations were measured during oral glucose tolerance test (OGTT) before and after GH treatment(0.6-0.7 IU/kg/week) in 20 patients with ISS. Insulin resistance was assessed by homeostasis model assessment(HOMA). Results : During OGTT, the mean...

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