Clinical and Experimental Pediatrics

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Original Article

Expression of Tumor Suppression Gene in Childhood Cancer

Ji Eun Lee, Myung Ik Lee, Chang Soo Park

Clin Exp Pediatr. 1998;41(3):383-389. Published online March 15, 1998

Purpose : Childhood cancer is closely related to the mutation of tumor suppressor gene. The mutant gene may evoke congenital anomaly and development of cancer. The common solid tumors in childhood are Wilms' tumor, retinoblastoma and neuroblastoma. The cytogenetic study has been performed. The cytogentic study revealed structural abnormality of chromosome in Wilms' tumor and retinoblastoma. The oncogene and mutation...

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