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Original Article
Hematology
Treatment and clinical outcomes of pediatric autoimmune hemolytic anemia: real-world single-center data from Korea
Young Dai Kwon, Eun Sun Jung, Yeon Jung Lim
Clin Exp Pediatr. 2025;68(7):522-529.   Published online April 16, 2025
Question: Can pediatric autoimmune hemolytic anemia (AIHA) be effectively managed using first-line steroids?
Finding: In this single-center study, pediatric patients with AIHA achieved normal hemoglobin levels within 16.5 days (range, 9.0–22.0 days) of first-line steroid treatment and maintained effective responses for 2 months.
Meaning: These outcomes highlight the efficacy of steroid treatment in pediatric versus adult AIHA and underscore the need for multicenter trials to establish standardized treatment guidelines.
Review Article
Hemolytic anemia in pediatrics
Jeong Ok Hah
Clin Exp Pediatr. 2007;50(6):511-518.   Published online June 15, 2007
To understand the hemolytic anemia (HA) in children, the diagnostic approach and management of hereditary and acquired HA are described. The hereditary hemolytic anemia (HHA) can be classified according to the pathogenesis into three types : RBC membrane defects, hemoglobinopathies, and RBC enzymopathies. Clinical characteristics, laboratory findings and molecular defects of these three types are presented briefly. In Korea,...
Case Report
A Case of Rothmund-Thomson Syndrome with Pure Red Cell Aplasia, Autoimmune Hemolytic Anemia and Chronic Respiratory Infection
Jung Hyun Lee, Eun Seok Roh, Yoo Rah Hong, Jae Sun Park, Ghi Seok Seo, Bang Hur, Mi Hyang Kim
Clin Exp Pediatr. 2004;47(12):1351-1355.   Published online December 15, 2004
Rothmund-Thomson syndrome(RTS), or poikiloderma congenita, is a rare, multisystem disorder. It is inherited genetically as an autosomal recessive trait, occurring predominantly in females(1.4 : 1). The RTS is comprised of poikiloderma, short stature, sparse hair, juvenile cataracts, skeletal defects, dystrophic teeth and nails, photosensitivity, and hypogonadism. We report a case of RTS who died of bleeding from esophageal varices, pulmonary...
A Case of Common Variable Immunodeficiency with Autoimmune Hemolytic Anemia
Kyung-Yil Lee, Yon-Joo Lee, Sang-Won Cha, Dong Joon Lee, Ji-Whan Han, Kyung-Tae Whang, Joong-Gon Kim
Clin Exp Pediatr. 2000;43(1):117-122.   Published online January 15, 2000
Common variable immunodeficiency(CVID) is a heterogeneous collection of disorders with hypogammaglobulinemia with recurrent bacterial infections and high incidence of autoimmune disorders as its hallmark. We report a 7-year-old girl suffering from CVID with Coombs' test positive hemolytic anemia. She had been relatively well until 23-months old when she was admitted to Taejon St. Mary' s Hospital with pneumonia 5 years ago. Afterwards, she had...
Original Article
A Case of Autoimmune Hemolytic Anemia Associated with Chronic Hepatitis in Children.
Kwan Mo Choi, Kyeong Hun Cha, Eun Yeong Kwak, Kyung Rae Moon, Yeong Bong Park
Clin Exp Pediatr. 1990;33(9):1288-1293.   Published online September 30, 1990
Recently, We experienced a case of autoimmune hemolytic anemia in a 13 year old female patient associated with chronic hepatitis. This female child manifested severe pallor, jaundice, abdominal pain and fever. This diagnosis was made on the bases of typical clinical features, C.B.C., blood chemistry, coombs test, warm antibody, immunoelectrophoresis, peripheral blood smear and bone marrow examination. The patient improved with steroid therapy. We report this...
Case Report
A Case of Autoimmune Hemolytic Anemia Associated with Acute Viral Hepatitis B.
Chong Kyu Woo, Eun Kyung Choi, Hae Ryung Chung, Dong Heuk Keum
Clin Exp Pediatr. 1987;30(9):1034-1039.   Published online September 30, 1987
We experienced a case of autoimmune hemolytic anemia in 3-year-old male patient associated with acute viral hepatitis B. Characteristic findings of this disease are pallor, fever, tachycardia, jaundice, hemoglobinuria, of which the onset is acute or chronic. Although the pathogenic mechanism of this disease is uncertain, it can be associated with pneumonia, measles, varicella, viral hepatitis (50%) and underlying autoinunune deficiency (32%). Diagnosis...
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