• Search
  • Advanced Search

Search

  • HOME
  • Search
Review Article
Hematology
Promising role of voxelotor in managing sickle cell disease in children: a narrative review
Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua
Clin Exp Pediatr. 2025;68(2):106-114.   Published online November 13, 2024
Voxelotor has promising ability to increase hemoglobin levels and reduce hemolysis markers in patients with sickle cell disease (SCD). Several preclinical and phase II/III trials have demonstrated its efficacy, dose-dependent responses, and tolerability in children. Ongoing trials are assessing its safety and effectiveness in various populations, including children younger than 12 years. These findings suggest its potential as a disease-modifying drug, warranting further exploration of its role in SCD management.
Original Article
Decreased Nonlinear Coupling of Peripheral Blood Volume to Heart Rate in Preterm Infants
Eun-Young Park, Chang-Ryul Kim, Myung-Kul Yum
Clin Exp Pediatr. 2004;47(4):386-391.   Published online April 15, 2004
Purpose : We investigated the autonomic nervous and complex modulation of heart rate and peripheral blood volume, and linear and nonlinear coupling between heart rate and peripheral blood volume in full-term and preterm infants. Methods : In twenty healthy preterm infants and twenty full-term infants at postconceptional age of 30-37 and 38-41 weeks each, we recorded electrocardiogram and photoplethysmogram simultaneously during...
Effect of Inhaled Nitric Oxide on Hemodynamics, Gas Exchange and Pulmonary Inflammation in Newborn Piglets with Escherichia coli Induced Septic Lungs
Yun Sil Chang, Sun Young Ko, Won Soon Park
Clin Exp Pediatr. 2003;46(8):777-783.   Published online August 15, 2003
Purpose : The aim of this study was to evaluate the effect of inhaled nitric oxide(iNO) on gas exchange, hemodynamics and pulmonary inflammation in newborn piglets with E. coli induced septic lung. Methods : Twenty three instrumented and ventilated piglets were randomized into three groups : CON(n=6), PCON(n=9), and PNO(n=8). In the piglets of the PCON and PNO groups, E. coli...
Effects of Partial Liquid Ventilation on Gas Exchange, Hemodynamics, and Pulmonary Function in Newborn Piglet with Respiratory Distress
Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(11):1430-1439.   Published online November 15, 2000
Purpose : To evaluate gas exchange, hemodynamics and pulmonary function during partial liquid ventilation(PLV) using PFC(perfluorodecalin), compared with conventional gas ventilation in newborn piglets with saline lavage-induced respiratory distress. Methods : In a total of 16 instrumented and ventilated piglets, acute respiratory distress(below 70 mmHg of PaO2 at FiO2 1.0) was induced by repeated saline pulmonary lavage. The piglets were randomized...
Case Report
Flexible Bronchoscopic Finding of Congenital Lobar Emphysema
Young Mee Seo, Jung Yeon Shim, Bong Seong Kim, So Duk Lim, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(1):133-137.   Published online January 15, 2000
Congenital lobar emphysema is a rare disease and a cause of respiratory distress in early infancy. The most common location of pulmonary involvement is the left upper lobe. We diagnosed a case of congenital lobar emphysema in a 5-month-old female infant, who had a complex heart disease using flexible bronchoscopy. In spite of palliative heart surgery, respiratory difficulty and cyanosis did not improve and...
Original Article
Doppler Echocardiographic Studies on Hemodynamic Changes in Early Neonatal Period.
Myung Kul Yum
Clin Exp Pediatr. 1989;32(2):158-164.   Published online February 28, 1989
Postnatal circulatory changes were studied with doppler echocardiography in 40 normal full term neonate before 6 hours, between 6 and 24 hours, and after 24 hours of age. The results of study were as follows; 1) Pulmonary artery flow velocity integral per minute which means total systemic blood flow increased during those period (854±58, 1027±128, 1198±57 cm/min). 2) Flow velocity integral per minute in ascendiing...
Pre-and Postoperative Evaluation of Patent Ductus Arteriosus in Children.
In Hee Park, Jung Hee Lee, In Joon Seol, Heung Jae Lee
Clin Exp Pediatr. 1985;28(7):683-694.   Published online July 31, 1985
During a period of IOV12 years, from April, 1974 to July, 1984, 92 cases under 15 years of age with isolated patent ductus arteriosus were observed and evaluated pre- and postoperatively at pediatric department, Hanyang University Hospital, and those were confirmed by cardiac catheterization and/or surgery. The summary of observation made is as follows: 1)The sex ratio of male to female...
Clinical and Hemodynamic Characteristics of Double Chambered Right Ventricle.
Seok Chol Jeon, Seung Ro Lee, Heung Seok Seo, Sam Hyun Kim, Hurn Chae, Kun Ho Kim, Seung Jae Yang, Hahng Lee, Heung Jae Lee
Clin Exp Pediatr. 1984;27(10):982-990.   Published online October 31, 1984
During the period from May 1981 to Feb. 1984, authors experienced 15 cases of double chambered right ventricle (D.C.R.V.) at Hanyang University Hospital. Among these 15 cases of D.C.R.V., 13 cases were confirmed by open heart surgery. We analysed the physical characteristics and echocardiographic, cardiac catheterization, angiographic and operative findings. Results are as follows; 1) Authors observations suggest that right ventricular obstructing...
A Clinical Study of Tic Disorder in Korea.
Kang E Hong
Clin Exp Pediatr. 1981;24(3):198-208.   Published online March 15, 1981
30 patients diagnosed as having tic disorder at the Child Psychiatry clinic of Seoul National University Hospital were studied in terms of sex, age, onset, precipitating factors,characteristics of the patients and family dynamics. A short term follow up study wascarried out regarding the outcomes of the symptom and the changes in attitudes and beha-viors of patients and parents. The results...
TOPICS

Browse all articles >

ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
FOR CONTRIBUTORS
ABOUT
Editorial Office
Korean Pediatric Society
#1606 Seocho World Officetel, 19 Seoun-ro, Seocho-ku, Seoul 06732, Korea
Tel: +82-2-3473-7306    Fax: +82-2-3473-7307    E-mail: office@e-cep.org                

Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)

Copyright © 2025 by Korean Pediatric Society.      Developed in M2PI