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Original Article

Three Cases of Typhlitis during Treatment for Acute Myelocytic Leukemia in Children.

Soon Mee Park, Il Soo Ha, Hoan Jong Lee, Jeong Kee Seo, Hyo Seop Ahn, Kyung Mo Yeon

Clin Exp Pediatr. 1989;32(10):1455-1462. Published online October 31, 1989

Typhlitis is a rare necrotizing colitis in which inflammation is confined to cecum. It occurs during chemotherapy for malignancies, in terminal stage of aplastic anemia, in transplant patients. The pathogenesis of typhlitis has included leukemic infiltration of the bowel, thrombocytopenia, direct toxic effects of chemotherapy, steroid, bacterial invasion of the bowel wall secondary to neutropenia and alteration of the bowel flora by broad-spectrum antibiotics....

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