Clinical and Experimental Pediatrics

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Original Article

Changes in Somatostatin Immunoreactive Neurons in Rat Corebral Cortes after Systemic Kainic acid Administration

Myung Yeun Lee, Sa Jun Chung, Chang Il Ahn

Clin Exp Pediatr. 1993;36(9):1279-1290. Published online September 15, 1993

This study was aimed to clarify the effects of systemic kainic acid(KA) administration(10mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical...

The mechanism of Arginine-stimulated growth hormone secretion.

Wan Kyu Lee, Dong Goo Lee, Duk Hi Kim

Clin Exp Pediatr. 1991;34(4):544-552. Published online April 30, 1991

Although Arginine is widely used in the evaluation of growth hormone (GH) secretion in short stature patient, the mechanism of action is unclear, yet. To elucidate how Arginine stimulate GH secretion, we studied the interaction of Arginine with growth homrone releasing hormone (GHRH) on GH secretion in GH deficient short stature patient and constitutional growth delay. The results of the studies were as follows: 1) Peak...

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