Clinical and Experimental Pediatrics

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Review Article

Autoimmunity

Joong Gon Kim

Clin Exp Pediatr. 2007;50(12):1165-1172. Published online December 15, 2007

Self/non-self discrimination and unresponsiveness to self is the fundamental properties of the immune system. Self-tolerance is a state in which the individual is incapable of developing an immune response to an individual's own antigens and it underlies the ability to remain tolerant of individual's own tissue components. Several mechanisms have been postulated to explain the tolerant state. They can be...

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