Clinical and Experimental Pediatrics

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Original Article

Serum amyloid A and proadrenomedullin as early markers in critically ill children with sepsis

Nagwan Saleh, Wafaa Abo El Fotoh, Mona Habib, Salem Deraz

Background: Pro-adrenomedullin (pro-ADM), the most stable part of ADM, serves as an indirect marker of ADM levels. Serum amyloid A (SAA) is a protein produced primarily in the liver during acute inflammation.
Purpose: To assess the role of SAA and pro-ADM, individually and in combination, as diagnostic and prognostic markers in pediatric sepsis. Methods: This prospective case-control cohort study included...

DOI: https://doi.org/10.3345/cep.2024.01928 [Accepted]

Oncology

Prognostic role of mid-regional pro-adrenomedullin in predicting infection in pediatric cancer with febrile neutropenia

Seham M. Ragab, Sara Mahmoud El-Deeb, Ahmed Saeed, Asmaa A. Mahmoud

Clin Exp Pediatr. 2025;68(6):445-453. Published online January 13, 2025

· Infection remains a leading cause of death in febrile neutropenia (FN).
· Mid-regional pro-adrenomedullin (MR-ProADM) levels are higher among patients with FN and a bacterial infection.
· A longer FN duration and hospital stay length as well as elevated C-reactive protein, procalcitonin, and MR-ProADM levels are significant risk factors for mortality.

DOI: https://doi.org/10.3345/cep.2024.01620

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Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)