Clinical and Experimental Pediatrics

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Original Article

Neonatology (Perinatology)

Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis

Ji Eun Jeong, Jae Hyun Park, Chun Soo Kim, Sang Lak Lee, Hai Lee Chung, Woo Taek Kim, Eun Joo Lee

Clin Exp Pediatr. 2017;60(6):181-188. Published online June 22, 2017

Crossref 13

Purpose

Hypoxic-ischemic encephalopathy is a significant cause of neonatal morbidity and mortality. Erythropoietin (EPO) is emerging as a therapeutic candidate for neuroprotection. Therefore, this study was designed to determine the neuroprotective role of recombinant human EPO (rHuEPO) and the possible mechanisms by which mitogen-activated protein kinase (MAPK) signaling pathway including extracellular signal-regulated kinase (ERK1/2), JNK, and p38 MAPK is modulated in...

DOI: https://doi.org/10.3345/kjp.2017.60.6.181

A pilot study of neuroprotection with umbilical cord blood cell transplantation for preterm very low birth weight infants

Kyu Young Chae, Kyu Hyung Lee, So-Hee Eun, Byung Min Choi, Baik-Lin Eun, Hoon-Chul Kang, Myung Jae Chey, Nam Keun Kim, Doyeun Oh

Clin Exp Pediatr. 2007;50(9):882-890. Published online September 15, 2007

Purpose : Preterm very low birth weight infant have high rate of adverse neurodevelopmental sequale. Recently, there have been lots of reports that human umbilical cord blood transplantation ameliorates functional deficits in animal models as hypoxic ischemic injury. This pilot study was undertaken to determine the clinical efficacy and safety of autologous umbilical cord blood cell transplantation for preventing neurodevelopmental...

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