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Role of Mast Cells in Allergic Inflammation and Innate Immunity

Kangmo Ahn

Clin Exp Pediatr. 2004;47(11):1137-1141. Published online November 15, 2004

Mast cells play a key role in elicitation of the early-phase and late-phase IgE-mediated allergic inflammatory reactions. Mast cells are derived from pluripotent stem cells from the bone marrow. These cells migrate through circulation into connective tissues and mucosal surfaces where they mature. On the cell surfaces, mast cells have high affinity IgE receptor(FcεRI), which react with specific IgE to...

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