Clinical and Experimental Pediatrics

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Original Article

Hepatitis B Virus Pre-S Gene Mutations in Children with Chronic Hepatitis B Infection

Jae Young Kim, Woo Yeong Chung, Chul Ho Kim

Clin Exp Pediatr. 2000;43(9):1232-1240. Published online September 15, 2000

Purpose : The envelope of HBV consists of three polypeptides which are encoded in pre-S/S open reading frame. Three translation initiation sites are present within this pre-S/S open reading frame, i.e. pre-S1, pre-S2, and S, allowing the expression of large, middle and small HBs proteins. The pre-S1 is thought to carry the receptor binding site for viral entry into hepatocyte...

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