Clinical and Experimental Pediatrics

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Original Article

Neonatology (Perinatology)

Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling

Behnaz Basiri, Mohammadkazem Sabzehei, Mohammadmahdi sabahi

Clin Exp Pediatr. 2021;64(4):180-187. Published online August 27, 2020

Web of Science 8 Crossref 9

Question: What is the most important factor that increases mortality in infants with hypoxic-ischemic encephalopathy (HIE) who receive selective head cooling?
Finding: All cases of neonatal mortality were severe HIE (stage 3), and a severely abnormal amplitude-integrated electroencephalography and mortality were increased with the need for advanced neonatal resuscitation upon delivery.
Meaning: Advanced neonatal resuscitation affects HIE outcomes, and medical personnel should be prepared to provide the best intervention.

DOI: https://doi.org/10.3345/cep.2019.01382

Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis

Ji Eun Jeong, Jae Hyun Park, Chun Soo Kim, Sang Lak Lee, Hai Lee Chung, Woo Taek Kim, Eun Joo Lee

Clin Exp Pediatr. 2017;60(6):181-188. Published online June 22, 2017

Crossref 13

Purpose

Hypoxic-ischemic encephalopathy is a significant cause of neonatal morbidity and mortality. Erythropoietin (EPO) is emerging as a therapeutic candidate for neuroprotection. Therefore, this study was designed to determine the neuroprotective role of recombinant human EPO (rHuEPO) and the possible mechanisms by which mitogen-activated protein kinase (MAPK) signaling pathway including extracellular signal-regulated kinase (ERK1/2), JNK, and p38 MAPK is modulated in...

DOI: https://doi.org/10.3345/kjp.2017.60.6.181

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