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Original Article

Ciclesonide shows a lung-protective effect in neonatal hyperoxia-exposed rats

Victoria Mielgo, Miguel A Gomez-Solaetxe, Lara Olazar, Begoña Loureiro, Carmen Rey-Santano

Background: Bronchopulmonary dysplasia (BPD), a chronic lung disease primarily observed in premature infants, is attributed to a lung injury–repair imbalance. Studies of postnatal corticosteroids have failed to identify clear candidates to help alleviate high BPD rates without risks or adverse effects.
Purpose: This study aimed to assess whether the systemic postnatal administration of an alternative glucocorticoid, ciclesonide, could attenuate alterations in lung structure and right ventricular hypertrophy in a...

DOI: https://doi.org/10.3345/cep.2025.01137 [Accepted]

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