Clinical and Experimental Pediatrics

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Original Article

The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats

Moon Sun Kim, Yoo Kyung Seo, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim

Clin Exp Pediatr. 2010;53(10):898-908. Published online October 31, 2010

Crossref 8

Purpose

The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available for such effects during the neonatal periods. Therefore, we investigated whether recombinant human EPO (rHuEPO) can protect against perinatal HI brain injury via an antiapoptotic mechanism.

Methods

The left carotid artery was ligated...

DOI: https://doi.org/10.3345/kjp.2010.53.10.898

Taurine exerts neuroprotective effects via anti-apoptosis in hypoxic-ischemic brain injury in neonatal rats

Ji Eun Jeong, Tae Yeol Kim, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim

Clin Exp Pediatr. 2009;52(12):1337-1347. Published online December 15, 2009

Purpose : Taurine (2-aminoethanesulfonic acid) is a simple sulfur-containing amino acid. It is abundantly present in tissues such as brain, retina, heart, and skeletal muscles. Current studies have demonstrated the neuroprotective effects of taurine, but limited data are available for such effects during neonatal period. The aim of this study was to determine whether taurine could reduce hypoxic-ischemic (HI) cerebral...

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