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Original Article

Studies on Mechanism of Vascular Hyporeactivity of Mesenteric Artery from Septic Rats

Man Chul Ha, Hee Ju Park, Ki Whan Hong

Clin Exp Pediatr. 1995;38(7):922-935. Published online July 15, 1995

Purpose : Septic shock due to gram negative bacterial infection is characterized by vasodil-ation, hypotension, and myocardial depression due to the effect of lipopolysaccharide (LPS). In spite of extensive studies, the mechanisms for the vascular effects of endotoxemia are not clear. Recently, it has been proposed that nitric oxide (NO) synthesized from L-arginine by nitric oxide synthase contributes to the...

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