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Original Article

Puromycin aminonucleoside modulates p130Cas of podocytes

Tae-Sun Ha, Ji-Young Choi, Hye-Young Park

Clin Exp Pediatr. 2012;55(10):371-376. Published online October 29, 2012

Crossref 3

Purpose

Puromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers to the glomerular basement membrane (GBM) and adapter proteins in glomerular epithelial cells (GEpCs; podocytes). We investigated the changes in the p130Cas expression level in the PAN-induced pathological changes of podocytes...

DOI: https://doi.org/10.3345/kjp.2012.55.10.371

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