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Original Article

Neonatology (Perinatology)

Thrombocytopenia in preterm infants born to mothers with systemic lupus erythematosus: a retrospective cohort study

Ru Xue, Guoqing Zhang, Xiafang Chen, Jun Bu, Lanlan Mi, Fei Bei

Clin Exp Pediatr. 2026;69(3):266-273. Published online December 22, 2025

Question: What are the characteristics and clinical implications of thrombocytopenia in preterm neonates born to mothers with systemic lupus erythematosus?
Finding: Nearly one-third of preterm infants developed thrombocytopenia. Key modulators of this risk included gestational age, maternal hypertensive disorders of pregnancy, and hydroxychloroquine use. Thrombocytopenia may be associated with neonatal morbidity.
Meaning: Platelet count should be monitored during the first week of life, and infants should be assessed for potential complications.

DOI: https://doi.org/10.3345/cep.2025.01942

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