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Original Article

Changes of Body Weight and Lipid Profiles According to Apolipoprotein E Polymorphism in Children with Antiepileptics

Seung Hee Jang, Eun Kyoung Choi, So Hee Eun, Sun Jun Kim

Clin Exp Pediatr. 2002;45(1):88-94. Published online January 15, 2002

Purpose : Weight changes, especially weight gain, is a side effect of antiepileptics(especially valproate and carbamazepine). This may be sufficiently severe to cause noncompliance or to require the withdrawal of effective treatment. Unfortunately, the exact mechanism of weight change is not illustrated. Several reports and our experiment suggested that weight gain highly correlated with a familial tendency of obesity. The genetic makeup is a...

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